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  • Institute of Modern Russian Culture Newsletter 57.2009.pdf

    Generic Work thumbnail: Institute of Modern Russian Culture Newsletter 57.2009.pdf
    Type:
    Generic Work
    Description/Abstract:
    Institute of Modern Russian Culture Newsletters 1979-2018. The newsletter is distributed biannually and provides information and events connected to the IMRC. The newsletter contains lists of books, journals, and catalogs related to the art and culture of Russia. It also lists events and exhibitions that took place during the year.
    Creator/Author:
    Bowlt, John and Konecny, Mark
    Submitter:
    Mark Konecny
    Date Uploaded:
    08/07/2018
    Date Modified:
    08/22/2018
    Date Created:
    2009-02
    License:
    Attribution 4.0 International

  • Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis

    Article thumbnail: Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis
    Type:
    Article
    Description/Abstract:
    Lupus nephritis (LN) is among the main determinants of poor prognosis in systemic lupus erythematosus (SLE). The objective of this study was to 1) isolate and identify proteins contained in the LN urinary protein signature (PS) of children with SLE; 2) assess the usefulness of the PS-proteins for detecting activity of LN over time. Using surface-enhanced or matrix assisted laser desorption/ ionization time of flight mass spectrometry, the proteins contained in the LN urinary PS were identified. They were transferrin (Tf), ceruloplasmin (Cp), α1-acid-glycoprotein (AGP), lipocalintype prostaglandin-D synthetase (L-PGDS), albumin and albumin-related fragments. Serial plasma and urine samples were analyzed using immunonephelometry or ELISA in 98 children with SLE (78% African-American) and 30 controls with juvenile idiopathic arthritis. All urinary PS-proteins were significantly higher with active versus inactive LN or in patients without LN (all p<0.005), and their combined area under the receiver operating characteristic curve was 0.85. As early as 3 months before a clinical diagnosis of worsening LN, significant increases of urinary Tf, AGP (both p < 0.0001) and L-PGDS (p < 0.01) occurred, indicating that these PS-proteins are biomarkers of LN activity and may help anticipate the future course of LN. Systemic Lupus Erythematosus (SLE) is an inflammatory autoimmune disease and lupus nephritis (LN) is one of the main determinants of poor prognosis (1). Currently, LN is gauged by measuring circulating and excreted indicators of renal dysfunction, with supporting information from kidney biopsies. The latter constitute the current standard for diagnosing LN, providing a direct assessment of the presence, severity and activity of LN, and the degree of renal damage (2). Due to the invasive nature of kidney biopsies, clinicians base LN activity and its therapy on the results of urinary protein excretion, urinary sediment, creatinine clearance and serum albumin. These traditional markers are not accurate in assessing whether active LN is present or not, and none of them is predictive, i.e. can anticipate the course of LN. Using Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF MS) technology, we previously identified a LN urinary protein signature (PS), consisting of eight candidate biomarkers at the mass-to-charge ratios (m/z) of 2.763, 22, 23, 44, 56, 79, 100, and 133 kDa (3). In this study, we present the identification of the specific proteins contained in this PS of children with LN. We further assayed plasma and urine samples of SLE patients and controls with juvenile idiopathic arthritis (JIA) to investigate the concurrent and predictive validity of the PS-proteins to serve as biomarkers of LN activity.
    Creator/Author:
    Tucker, Lori; Brunner, Hermine I.; Wiers, Kristina; Olson, Judyann; Suzuki, Michiko; Onel, Karen; Ying, Jun; Greis, Kenneth D.; Devarajan, Prasad; Haines, Kathleen; O'Neil, Kathleen M.; Silverman, Earl D.; Klein-Gitelman, Marisa S., and Brooks, Elizabeth B.
    Submitter:
    Kenneth Greis
    Date Uploaded:
    03/03/2017
    Date Modified:
    04/07/2017
    Date Created:
    2009-02
    License:
    All rights reserved

  • Integration of Computations and Experiments for Flow Control Research With Undergraduate Students

    Article thumbnail: Integration of Computations and Experiments for Flow Control Research With Undergraduate Students
    Type:
    Article
    Description/Abstract:
    The methods and outcome of a senior undergraduate project related to the control of a turbulent cylinder wake flow using plasma actuators are summarized in this article. The study integrates computational fluid dynamics (CFD) with experimentation and combines fluid mechanics with flow control research, crossing the boundaries between engineering disciplines.Comput. Appl. Eng. Educ.
    Creator/Author:
    Cohen, Kelly; McLaughlin, Thomas; Seaver, Christopher A., and Aradag, Selin
    Submitter:
    Kelly Cohen
    Date Uploaded:
    02/08/2017
    Date Modified:
    04/05/2017
    Date Created:
    2009-02
    License:
    All rights reserved