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Insertional Mutagenesis Identifies a STAT3/Arid1b/ b-catenin Pathway Driving Neurofibroma Initiation

Type:

Article

Description/Abstract:

Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis.

Creator/Author:

Spinner, R. J.; Ratner, N.; Largaespada, D. A.; Keng, V.; Patmore, D. M.; Wu, J., and Cancelas, Jose A.

Submitter:

Jose Cancelas

Date Uploaded:

02/08/2017

Date Modified:

04/10/2017

Date Created:

2016-02

License:

All rights reserved