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  • Creating metadata out of thin air and managing large batch imports

    Generic Work thumbnail: Creating metadata out of thin air and managing large batch imports
    Type:
    Generic Work
    Description/Abstract:
    A presentation and paper delivered at Open Repositories 2012, the 7th International Conference on Open Repositories, held in Edinburgh, Scotland, July 9-13, 2012.
    Creator/Author:
    Newman, Linda
    Submitter:
    Linda Newman
    Date Uploaded:
    12/08/2016
    Date Modified:
    12/08/2016
    Date Created:
    2012-07-12
    License:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • Nemaster grandis 3

    Image thumbnail: Nemaster grandis 3
    Type:
    Image
    Description/Abstract:
    N. grandis attached to seagrass.
    Creator/Author:
    Sacco, William K. (photographer) and Meyer, David L.
    Submitter:
    David L. Meyer
    Date Uploaded:
    04/22/2016
    Date Modified:
    08/02/2016
    Date Created:
    2016-04-22
    License:
    Attribution-NonCommercial 4.0 International

  • Nemaster grandis 2

    Image thumbnail: Nemaster grandis 2
    Type:
    Image
    Description/Abstract:
    N. grandis attached to seagrass.
    Creator/Author:
    Sacco, William K. (photographer) and Meyer, David L.
    Submitter:
    David L. Meyer
    Date Uploaded:
    04/22/2016
    Date Modified:
    08/02/2016
    Date Created:
    2016-04-22
    License:
    Attribution-NonCommercial 4.0 International

  • Nemaster grandis 1

    Image thumbnail: Nemaster grandis 1
    Type:
    Image
    Description/Abstract:
    N. grandis attached to seagrass.
    Creator/Author:
    Sacco, William K. (photographer) and Meyer, David L.
    Submitter:
    David L. Meyer
    Date Uploaded:
    04/22/2016
    Date Modified:
    08/02/2016
    Date Created:
    2016-04-22
    License:
    Attribution-NonCommercial 4.0 International

  • Crinoidea from Colombia

    Generic Work thumbnail: Crinoidea from Colombia
    Type:
    Generic Work
    Description/Abstract:
    Underwater photos of comatulid crinoids from the Caribbean coast of Colombia
    Creator/Author:
    Meyer, David L.
    Submitter:
    David L. Meyer
    Date Uploaded:
    10/27/2017
    Date Modified:
    11/02/2017
    License:
    All rights reserved

  • Spring's Mix Demo

    Media thumbnail: Spring's Mix Demo
    Type:
    Media
    Description/Abstract:
    Three part work created for my exhibition at Shirley Jones Gallery in Yellow Springs, Ohio. Features dance treatments from Experimental Television Center, as well as footage from my backyard on Riddle Rd in Cincinnati. The piece was projected onto the store front windows of the gallery.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    04/15/2016
    Date Modified:
    05/07/2019
    Date Created:
    2006
    License:
    All rights reserved

  • Legal Research Using Books

    Media thumbnail: Legal Research Using Books
    Type:
    Media
    Description/Abstract:
    A video series that walks the viewer through the process of conducting legal research using paper resources. Video 1 -- Legal Research: Intro Video 2 -- Legal Research: Define Problem Video 3 -- Legal Research: Find a Starting Point Video 4 -- Legal Research: Read Starting Point Video 5 -- Legal Research: Additional Material Video 6 -- Legal Research: Validation Video 7 -- Legal Research: Summary
    Creator/Author:
    Davis, Bruce, Wm.
    Submitter:
    Wm. Bruce Davis
    Date Uploaded:
    12/07/2016
    Date Modified:
    12/08/2016
    License:
    Attribution-NonCommercial-ShareAlike 4.0 International

  • Nemaster grandis 1

    Image thumbnail: Nemaster grandis 1
    Type:
    Image
    Description/Abstract:
    Nemaster grandis on tube sponge
    Creator/Author:
    Roessler, Carl (photographer) and Meyer, David L.
    Submitter:
    David L. Meyer
    Date Uploaded:
    04/14/2016
    Date Modified:
    08/01/2016
    Date Created:
    2016-04-14
    License:
    Attribution-NonCommercial 4.0 International

  • Functional Characterization and Localization of Pneumocystis lanosterol synthase

    Article thumbnail: Functional Characterization and Localization of Pneumocystis lanosterol synthase
    Type:
    Article
    Description/Abstract:
    Organisms in the genus Pneumocystis are ubiquitous, opportunistic pathogenic fungi capable of causing a lethal pneumonia in immunocompromised mammalian hosts. Pneumocystis spp. are unique members of the fungal kingdom due to the absence of ergosterol in their cellular membranes. Although these organisms were thought to obtain cholesterol by scavenging, transcriptional analyses indicate that Pneumocystis carinii encodes gene homologs involved in sterol biosynthesis. To better understand the sterol pathway in these uncultivable fungi, yeast deletion strains were used to interrogate the function and localization of P. carinii lanosterol synthase (ERG7). The expression of PcErg7p in an ERG7-null mutant of the yeast Saccharomyces cerevisiae did not alter its growth rate and produced a functional lanosterol synthase, as evidenced by the presence of lanosterol detected by gas chromatographic analysis in levels comparable to that produced by the yeast enzyme. Western blotting and fluorescence microscopy revealed that, like the S. cerevisiae Erg7p, the PcErg7p localized to lipid particles in yeast. Using fluorescence microscopy, we show for the first time the presence of apparent lipid particles in P. carinii and the localization of PcErg7p to lipid particles in P. carinii. The detection of lipid particles in P. carinii and their association with PcErg7p therein provide strong evidence that the enzyme serves a similar function in P. carinii. Moreover, the yeast heterologous system should be a useful tool for further analysis of the P. carinii sterol pathway.
    Creator/Author:
    Grant, Tiffany
    Submitter:
    Tiffany Grant
    Date Uploaded:
    04/14/2016
    Date Modified:
    04/14/2016
    License:
    All rights reserved

  • Sterol biosynthesis and sterol uptake in the funal pathogen Pneumocsytis carinii

    Article thumbnail: Sterol biosynthesis and sterol uptake in the funal pathogen Pneumocsytis carinii
    Type:
    Article
    Description/Abstract:
    Members of the fungal genus Pneumocystis colonize healthy mammalian hosts without causing apparent disease, but colonization in immunocompromised hosts may result in a potentially fatal pneumonia known as Pneumocystis pneumonia. Although Pneumocystis are fungi, this genus has characteristics that make it atypical among other fungi. Pneumocystis do not appear to synthesize the major fungal sterol, ergosterol, and biochemical analyses have shown that they utilize cholesterol rather than ergosterol as the bulk sterol. Pneumocystis carinii appears to scavenge exogenous sterols, including cholesterol, from its mammalian host. As a result, it has long been held that their ability to scavenge cholesterol from their hosts, and their inability to undergo sterol biosynthesis, makes them resistant to antifungal drugs that target ergosterol or ergosterol biosynthesis. However, genome scans and in vitro assays indicate the presence of sterol biosynthetic genes within the P. carinii genome, and targeted inhibition of these enzymes resulted in reduced viability of P. carinii, suggesting that these enzymes are functional within the organism. Heterologous expression of P. carinii sterol genes, along with biochemical analyses of the lipid content of P. carinii cellular membranes, have provided an insight into sterol biosynthesis and the sterol-scavenging mechanisms used by these fungi.
    Creator/Author:
    Grant, Tiffany
    Submitter:
    Tiffany Grant
    Date Uploaded:
    04/14/2016
    Date Modified:
    04/14/2016
    License:
    All rights reserved