Background: Non-muscle myosin IIA (NMIIA; encoded by MYH9) has been implicated in breast cancer progression; however, its clinical significance and therapeutic potential in HER2-positive (HER2+) breast cancer remain poorly defined. We investigated the clinical significance of NMIIA and evaluated the anti-tumour activity of the selective NMII inhibitor MT-228.
Methods: NMIIA expression was evaluated by immunohistochemistry in a cohort of 1,142 patients with early-stage invasive breast cancer. Molecular docking and molecular dynamics simulations were performed to characterize binding of MT-228 to NMIIA. The effects of MT-228 were assessed in breast cancer cell lines using assays of cell viability, migration, three-dimensional invasion, DNA damage, apoptosis, and combination studies with FDA approved HER kinase inhibitors Neratinib and Tucatinib.
Results: High NMIIA expression was associated with adverse clinical outcomes in patients with HER2 immunoreactive breast cancer. Computational analyses demonstrated that MT-228 forms favorable binding interactions and stabilized the NMIIA motor domain. MT-228 inhibited cell growth across multiple breast cancer subtypes. In HER2+ cell lines, MT-228 suppressed migration and 3D invasion, increased γH2AX foci formation, caspase-3/7 enzyme activity, and PARP cleavage, and enhanced the anti-proliferative activity of Neratinib and Tucatinib.
Conclusions: Our findings identify NMII as a potential therapeutic target in HER2 immunoreactive breast cancer and support further investigation of selective NMII inhibition either alone or in combination with anti-HER therapies.
Podcasts produced by students participating in the REALIZE REU at University of Cincinnati.
This collection is still growing and is a work in progress.
The documents in this collection relate to writings on the subject of archaeometry, technical ceramics, artists materials, and historical research. Techniques such as X-ray Diffraction, X-Ray Fluorescence, Spectroscopy, wet chemical analysis are used to analyze historical and contemporary materials.
The School of Information Technology (SoIT) at the University of Cincinnati hosts the Information Technology Research Symposium on an annual basis as a forum for the exchange and dissemination of research ideas through the IT EXPO. The 2026 symposium was held on April 13-14, 2026 and this collection features the digital proceedings of presentations. The primary purpose of the symposium is to exchange research ideas among graduate students, faculty, industry, and practitioners involved in IT research in our field. IT research topics range from state-of-the-art system development to recent progress in scientific endeavors that are theoretical or applied areas of Information Technology, such as cybersecurity, data analytics, Internet of Things (IoT), IT infrastructure, interactive gaming, technologies for smart and connected cities, and user-centered design among others.
G-LiHT Yucatan Peninsula - 33cm / pixel DEM GeoTIFF files
Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S).
Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download.
To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
G-LiHT Yucatan Peninsula - G1 layered visualization GeoTIFF files
Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S).
Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download.
To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
