{"response":{"docs":[{"system_create_dtsi":"2017-10-27T02:52:52Z","system_modified_dtsi":"2018-08-01T18:40:08Z","has_model_ssim":["Article"],"id":"bc387109d","accessControl_ssim":["85479afc-2a77-4cc2-b4ea-246a7a40cb57"],"hasRelatedMediaFragment_ssim":["bc3871105"],"hasRelatedImage_ssim":["bc3871105"],"depositor_ssim":["greiskd@ucmail.uc.edu"],"depositor_tesim":["greiskd@ucmail.uc.edu"],"title_tesim":["The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases"],"date_uploaded_dtsi":"2017-03-03T00:00:00Z","date_modified_dtsi":"2017-04-07T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1074/jbc.M114.593616"],"journal_title_tesim":["Journal of Biological Chemistry"],"college_tesim":["Medicine"],"department_tesim":["Cancer \u0026 Cell Biology"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Grabowski, Gregory A.","Haffey, Wendy D.","Greis, Kenneth D.","Llou, Benjamin"],"subject_tesim":["Biological Chemistry","Cancer Biology"],"language_tesim":["English"],"description_tesim":["Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2.\n\nResults: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome.\n\nConclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome.\n\nSignificance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease)."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2014-09"],"source_tesim":["Journal of Biological Chemistry"],"thumbnail_path_ss":"/downloads/bc3871105?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc3871105"],"file_set_ids_ssim":["bc3871105"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"LIMP2SCARB2 BINDING MOTIF ON ACID BETAGLUCOSIDASE BASIC AND APPLIED IMPLICATIONS FOR GAUCHER DISEASE AND ASSOCIATED NEURODEGENERATIVE DISEASES","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["greiskd@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc387109d"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697084173403029504,"timestamp":"2021-04-15T05:46:28.954Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:52:01Z","system_modified_dtsi":"2018-08-01T18:40:10Z","has_model_ssim":["Article"],"id":"bc3870851","accessControl_ssim":["57e582d4-c063-4af3-bfca-dc5c034433bc"],"hasRelatedMediaFragment_ssim":["bc3870869"],"hasRelatedImage_ssim":["bc3870869"],"depositor_ssim":["greiskd@ucmail.uc.edu"],"depositor_tesim":["greiskd@ucmail.uc.edu"],"title_tesim":["Apolipoprotein A-II-mediated Conformational Changes of Apolipoprotein A-I in Discoidal High Density Lipoproteins"],"date_uploaded_dtsi":"2017-03-01T00:00:00Z","date_modified_dtsi":"2017-04-07T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["DOI 10.1074/jbc.M111.291070"],"journal_title_tesim":["Journal of Biological Chemistry"],"college_tesim":["Medicine"],"department_tesim":["Cancer \u0026 Cell Biology"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Gauthamadasa, Kekulawalage","Vaitinadin, Nataraja Sarma","Homan, Reyn","Macha, Stephen","Dresman, James L.","D. Silva, R. A. Gangani","Greis, Kenneth D."],"subject_tesim":["Biological Chemistry"],"language_tesim":["English"],"description_tesim":["Background: Role of apolipoprotein (apo) A-II on metabolism of high density lipoproteins (HDLs) is unknown.\n\nResults: Conformational changes of apoA-I, the major apolipoprotein of HDL, caused by apoA-II in discoidal HDL are confined to two regions of apoA-I.\n\nConclusion: Interactions between the two major apolipoproteins in discoidal HDL are site specific.\n\nSignificance: Functional implications of HDL complexes will significantly benefit from such structural information."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2012-03"],"source_tesim":["Journal of Biological Chemistry"],"thumbnail_path_ss":"/downloads/bc3870869?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc3870869"],"file_set_ids_ssim":["bc3870869"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"APOLIPOPROTEIN AIIMEDIATED CONFORMATIONAL CHANGES OF APOLIPOPROTEIN AI IN DISCOIDAL HIGH DENSITY LIPOPROTEINS","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["greiskd@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc3870851"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697097727010144256,"timestamp":"2021-04-15T09:21:54.681Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:51:57Z","system_modified_dtsi":"2018-08-01T18:40:11Z","has_model_ssim":["Article"],"id":"bc387083g","accessControl_ssim":["dcde149e-28a4-44b8-8619-4b9bc785fbde"],"hasRelatedMediaFragment_ssim":["bc387084r"],"hasRelatedImage_ssim":["bc387084r"],"depositor_ssim":["greiskd@ucmail.uc.edu"],"depositor_tesim":["greiskd@ucmail.uc.edu"],"title_tesim":["Refined Structure of the Lipophosphoglycan of Leishmania donovani"],"date_uploaded_dtsi":"2017-03-01T00:00:00Z","date_modified_dtsi":"2017-04-07T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"journal_title_tesim":["Journal of Biological Chemistry"],"college_tesim":["Medicine"],"department_tesim":["Cancer \u0026 Cell Biology"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Ferguson, Michael A. J.","Turco, Salvatore J.","Thomas, Jerry R.","Gorin, Philip A. J.","Homans, Steven W.","McConville, Malcom J.","Greis, Kenneth D.","Thomas-Oates, Jane E."],"subject_tesim":["Biological Chemistry","Biology"],"language_tesim":["English"],"description_tesim":["The primary structure of the major surface glycoconjugate of Leishmania donovani parasites, a lipophosphoglycan, has been further characterized. The repeating PO4-6Galp beta 1-4Man disaccharide units, which are a salient feature of the molecule, are shown to terminate with one of several neutral structures, the most abundant of which is the branched trisaccharide Galp beta 1-4(Manp alpha 1-2)Man. The phosphosaccharide core of lipophosphoglycan, which links the disaccharide repeats to a lipid anchor, contains 2 phosphate residues. One of the core phosphates has previously been localized on O-6 of the galactosyl residue distal to the lipid anchor; the second phosphate is now shown to be on O-6 of the mannosyl residue distal to the anchor and to bear an alpha-linked glucopyranosyl residue. Also, the anomeric configuration of the unusual 3-substituted Galf residue in the phosphosaccharide core is established as beta. The complete structure of the core is thus PO4-6Galp alpha 1-6Galp alpha 1-3Galf beta 1-3[Glcp alpha 1-PO4-6]Manp alpha 1-3Manp alpha 1-4GlcN alpha 1-. This further clarification of the structure of lipophosphoglycan may prove beneficial in determining the structure-function relationships of this highly unusual glycoconjugate."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1992-05"],"source_tesim":["Journal of Biological Chemistry"],"thumbnail_path_ss":"/downloads/bc387084r?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc387084r"],"file_set_ids_ssim":["bc387084r"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"REFINED STRUCTURE OF THE LIPOPHOSPHOGLYCAN OF LEISHMANIA DONOVANI","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["greiskd@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc387083g"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697115499946573824,"timestamp":"2021-04-15T14:04:24.274Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:51:52Z","system_modified_dtsi":"2018-08-01T18:40:09Z","has_model_ssim":["Article"],"id":"bc387081x","accessControl_ssim":["add9072d-1ff4-4d50-a075-c58b872a6fc5"],"hasRelatedMediaFragment_ssim":["bc3870826"],"hasRelatedImage_ssim":["bc3870826"],"depositor_ssim":["greiskd@ucmail.uc.edu"],"depositor_tesim":["greiskd@ucmail.uc.edu"],"title_tesim":["Purification and Characterization an Extracellular Phosphoglycan from Leishmania donovani"],"date_uploaded_dtsi":"2017-03-01T00:00:00Z","date_modified_dtsi":"2017-04-07T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"journal_title_tesim":["Journal of Biological Chemistry"],"college_tesim":["Medicine"],"department_tesim":["Cancer \u0026 Cell Biology"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Turco, Salvatore J.","Thomas, Jerry R.","Homans, Steven W.","Ferguson, Michael A.","McConville, Malcolm J.","Greis, Kenneth D."],"subject_tesim":["Biological Chemistry","Biology"],"language_tesim":["English"],"description_tesim":["An extracellular phosphoglycan (exPG), present in the culturem edium of the promastigote form L oefi shmania donovani, was purified and structurally characterized. The purification scheme included ethanol precipitation of the culture medium, anion exchange chromatography, hydrophobic chromatography on phenyl-Sepharose, and preparative polyacrylamgeild e electrophoresis. Structural analysis by ‘H-’H NMR, methylation linkage analysis, and glycosidase digestion revealed that the exPG consisted of thfoel lowing structure: (CAP)+[P04-6Galp@1-4Manpal]lo-11-POr6GalpB1-4Man. The capw as found to be ones eovf eral small, neutral oligosaccharides, the most abundant of which was the trisaccharide Galp@l-4(Manpal-2)Man. The results indicated structural analogy to the cellular-derived lipophosphoglycan (LPG) from L. donovani. The important exceptions are a lacko f the lipid anchor, the entire phosphosaccharide core, and several of the repeating disaccharide units. Although the function of exPGis presently unknowni,t may play a protective role for the promastigote in the insect vector or during infection of a mammalian host "],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1992-04"],"source_tesim":["Journal of Biological Chemistry"],"thumbnail_path_ss":"/downloads/bc3870826?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc3870826"],"file_set_ids_ssim":["bc3870826"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"PURIFICATION AND CHARACTERIZATION AN EXTRACELLULAR PHOSPHOGLYCAN FROM LEISHMANIA DONOVANI","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["greiskd@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc387081x"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697096093120069632,"timestamp":"2021-04-15T08:55:56.482Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":4,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Greis, Kenneth D.","hits":4,"label":"Greis, Kenneth D."},{"value":"Homans, Steven W.","hits":2,"label":"Homans, Steven W."},{"value":"Thomas, Jerry R.","hits":2,"label":"Thomas, Jerry R."},{"value":"Turco, Salvatore J.","hits":2,"label":"Turco, Salvatore J."},{"value":"D. Silva, R. A. Gangani","hits":1,"label":"D. Silva, R. A. Gangani"},{"value":"Dresman, James L.","hits":1,"label":"Dresman, James L."}],"label":"Creator Sim"},{"name":"subject_sim","items":[{"value":"Biological Chemistry","hits":4,"label":"Biological Chemistry"},{"value":"Biology","hits":2,"label":"Biology"},{"value":"Cancer Biology","hits":1,"label":"Cancer Biology"}],"label":"Subject Sim"},{"name":"college_sim","items":[{"value":"Medicine","hits":4,"label":"Medicine"}],"label":"College Sim"},{"name":"department_sim","items":[{"value":"Cancer \u0026 Cell Biology","hits":4,"label":"Cancer \u0026 Cell Biology"}],"label":"Department Sim"},{"name":"language_sim","items":[{"value":"English","hits":4,"label":"English"}],"label":"Language Sim"},{"name":"publisher_sim","items":[],"label":"Publisher Sim"},{"name":"date_created_sim","items":[{"value":"1992-04","hits":1,"label":"1992-04"},{"value":"1992-05","hits":1,"label":"1992-05"},{"value":"2012-03","hits":1,"label":"2012-03"},{"value":"2014-09","hits":1,"label":"2014-09"}],"label":"Date Created Sim"},{"name":"member_of_collection_ids_ssim","items":[],"label":"Member Of Collection Ids Ssim"},{"name":"generic_type_sim","items":[{"value":"Work","hits":4,"label":"Work"}],"label":"Generic Type Sim"}],"pages":{"current_page":1,"next_page":null,"prev_page":null,"total_pages":1,"limit_value":10,"offset_value":0,"total_count":4,"first_page?":true,"last_page?":true}}}