{"response":{"docs":[{"system_create_dtsi":"2019-02-05T21:30:59Z","system_modified_dtsi":"2019-06-06T15:04:45Z","has_model_ssim":["Document"],"id":"rr171z33v","accessControl_ssim":["de038863-1e17-4505-aeaf-734d10aca824"],"hasRelatedMediaFragment_ssim":["4x51hk15c"],"hasRelatedImage_ssim":["4x51hk15c"],"depositor_ssim":["joffritm@ucmail.uc.edu"],"depositor_tesim":["joffritm@ucmail.uc.edu"],"title_tesim":["Researcher Services: Proposal to Increase Distinctive Excellence"],"date_uploaded_dtsi":"2019-02-05T21:30:59Z","date_modified_dtsi":"2019-02-05T21:30:59Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C2TM5X"],"college_tesim":["Libraries"],"department_tesim":["HSL Info \u0026 Edu Svcs"],"creator_tesim":["Koshoffer, Amy","Baldwin, Ted","Burgess, Kristen","Grant, Tiffany"],"publisher_tesim":["University of Cincinnati","University of Cincinnati Libraries "],"description_tesim":["This document details our process for creating a service catalog for UC Libraries Research and Data Services and our efforts towards offering data science services. 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Our activities infuse across the institution, including the main campus and the Academic Health Center campus, and we oversee innovative spaces that respond to the particular needs of research communities, including informatics, geospatial analysis and data visualization. Since the fall 2015 CNI presentation on the UC Informationists (\"New Roles, New Collaborations: Developing an Informationist Program to Support University Research\"), we have greatly expanded our partnerships, services and educational offerings. We are now active in data and statistical consulting, collaborations on bioinformatics education, impactful community engagements (e.g., UC Data Day), and deep partnerships with the UC IT unit on initiatives such as the Data \u0026 Computational Science Series. At present, we are pursuing a new and challenging vision to realign our work in order to enable the institution's agendas for data science and innovation. We will discuss our experience with scalable growth and other successes in Research \u0026 Data Services and our assessment of a future in data science."],"license_tesim":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"date_created_tesim":["2018-12-10"],"thumbnail_path_ss":"/downloads/rn3012238?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["rn3012238"],"member_of_collections_ssim":["Presentations - Ted Baldwin"],"member_of_collection_ids_ssim":["zp38wd30f"],"file_set_ids_ssim":["rn3012238"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"TRANSFORMING THE UC INFORMATIONIST PROGRAM GROWING AND ALIGNING TOWARD DATA SCIENCE PROJECT BRIEFING CNI FALL 2018 MEMBERSHIP MEETING","human_readable_type_tesim":["Generic Work"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["baldwitw@ucmail.uc.edu"],"nesting_collection__ancestors_ssim":["zp38wd30f"],"nesting_collection__parent_ids_ssim":["zp38wd30f"],"nesting_collection__pathnames_ssim":["zp38wd30f/bg257g39h"],"nesting_collection__deepest_nested_depth_isi":2,"_version_":1697118600331001856,"timestamp":"2021-04-15T14:53:41.031Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T01:05:53Z","system_modified_dtsi":"2019-06-06T15:05:24Z","has_model_ssim":["Document"],"id":"ff365560t","accessControl_ssim":["b7d91108-5428-40bb-acc2-5c16a6e10e3d"],"hasRelatedMediaFragment_ssim":["ff3655613"],"hasRelatedImage_ssim":["ff3655613"],"depositor_ssim":["joffritm@ucmail.uc.edu"],"depositor_tesim":["joffritm@ucmail.uc.edu"],"title_tesim":["Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocsytis carinii"],"date_uploaded_dtsi":"2016-04-14T00:00:00Z","date_modified_dtsi":"2016-08-09T00:00:00Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C2S889"],"college_tesim":["Other"],"department_tesim":["HSL Info \u0026 Edu Svcs"],"creator_tesim":["Grant, Tiffany"],"publisher_tesim":["University of Cincinnati"],"description_tesim":["\nFungi in the genus Pneumocystis are the cause of a potentially life threatening\npneumonia, Pneumocystis pneumonia (PCP). The understanding of the lifecycle, metabolism, and drug development has been hindered due to a lack of a long term in vitro culture system. Unlike most other fungi, members of the genus Pneumocystis do not appear to synthesize the major fungal sterol, ergosterol. However, genome scans and in vitro assays suggest the presence of functional genes involved in a sterol pathway. One of the goals of this work was to characterize the P. carinii sterol enzyme, lanosterol synthase (Erg7p), an essential enzyme of the sterol pathway. The activity of P. carinii Erg7p was assessed by heterologous expression of P. carinii Erg7p in a Saccharomyces cerevisiae Erg7p null mutant. Growth rates and lanosterol production were similar between S. cerevisiae expressing the P. carinii enzyme and S. cerevisiae expressing its own Erg7p under the same conditions, indicating that not only does P. carinii produce a functional Erg7p, but also that the enzyme functionally complements the S. cerevisiae enzyme. Western blotting and fluorescent localization studies revealed that P. carinii Erg7p localizes to lipid particles in S. cerevisiae as does S. cerevisiae Erg7p. A novel finding of these studies, was that P. carinii contains lipid particles, and that P. carinii Erg7p localizes to lipid particles in P. carinii. These studies indicate that P. carinii Erg7p functions similar to the S. cerevisiae enzyme, and may perform a similar function in P. carinii.\n\nBiochemical analyses of sterols within the membranes of P. carinii have shown that it utilizes cholesterol rather than ergosterol as its bulk sterol. However, P. carinii does not appear to synthesize cholesterol from a de novo pathway, but rather scavenges\nexogenous sterols from its mammalian host. S. cerevisiae is induced to undergo sterol\nscavenging under anaerobic conditions. Consequently, another goal of this work was to provide information on the effect of O2 on sterol biosynthesis and sterol scavenging by P. carinii. ATP measurements revealed that the viability of P. carinii is severely decreased when maintained under hypoxic conditions, and this decrease correlated with an increase in drug susceptibility. We show that uptake of exogenous cholesterol by P. carinii occurred under normal O2 tensions, indicating that sterol scavenging is not limited to anaerobic conditions. Microarray analysis indicated that hypoxic maintenance of P. carinii resulted in decreased transcription of several genes involved in sterol and lipid biosynthesis suggesting that while hypoxic conditions down-regulated genes involved in sterol biosynthesis, down-regulation of sterol biosynthesis is not a requirement for sterol scavenging in P. carinii. The ability of P. carinii to scavenge exogenous sterols under normal O2 tensions at which the sterol pathway is unaffected provides evidence that sterol scavenging may be the primary means that P. carinii utilizes to obtain its sterols.\n\n\n\n  "],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"thumbnail_path_ss":"/downloads/ff3655613?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["ff3655613"],"file_set_ids_ssim":["ff3655613"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"STEROL BIOSYNTHESIS AND STEROL UPTAKE IN THE FUNGAL PATHOGEN PNEUMOCSYTIS CARINII","human_readable_type_tesim":["Document"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["joffritm@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["ff365560t"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697081617401511936,"timestamp":"2021-04-15T05:05:51.361Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Document","hits":2,"label":"Document"},{"value":"Generic Work","hits":1,"label":"Generic Work"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Grant, Tiffany","hits":3,"label":"Grant, Tiffany"},{"value":"Baldwin, Ted","hits":2,"label":"Baldwin, Ted"},{"value":"Burgess, Kristen","hits":1,"label":"Burgess, Kristen"},{"value":"Koshoffer, Amy","hits":1,"label":"Koshoffer, Amy"}],"label":"Creator Sim"},{"name":"subject_sim","items":[],"label":"Subject Sim"},{"name":"college_sim","items":[{"value":"Libraries","hits":2,"label":"Libraries"},{"value":"Other","hits":1,"label":"Other"}],"label":"College Sim"},{"name":"department_sim","items":[{"value":"HSL Info \u0026 Edu Svcs","hits":2,"label":"HSL Info \u0026 Edu Svcs"},{"value":"Science \u0026 Health Sciences","hits":1,"label":"Science \u0026 Health Sciences"}],"label":"Department Sim"},{"name":"language_sim","items":[],"label":"Language Sim"},{"name":"publisher_sim","items":[{"value":"University of Cincinnati","hits":3,"label":"University of Cincinnati"},{"value":"University of Cincinnati Libraries ","hits":1,"label":"University of Cincinnati Libraries "}],"label":"Publisher Sim"},{"name":"date_created_sim","items":[{"value":"2018-12-10","hits":1,"label":"2018-12-10"}],"label":"Date Created Sim"},{"name":"member_of_collection_ids_ssim","items":[{"value":"zp38wd30f","hits":1,"label":"zp38wd30f"}],"label":"Member Of Collection Ids Ssim"},{"name":"generic_type_sim","items":[{"value":"Work","hits":3,"label":"Work"}],"label":"Generic Type Sim"}],"pages":{"current_page":1,"next_page":null,"prev_page":null,"total_pages":1,"limit_value":10,"offset_value":0,"total_count":3,"first_page?":true,"last_page?":true}}}