{"response":{"docs":[{"system_create_dtsi":"2017-10-27T02:31:23Z","system_modified_dtsi":"2018-08-01T18:36:55Z","has_model_ssim":["Article"],"id":"bc386t090","accessControl_ssim":["1ccf01ad-da31-40b5-a0b4-9f22bc0db581"],"hasRelatedMediaFragment_ssim":["bc386t10r"],"hasRelatedImage_ssim":["bc386t10r"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-kB Gene Network"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-kB Gene Network"],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Komurov, K.","Maciejewski, J. P.","Bolanos, L.","Grimes, H. L.","Cancelas, Jose A.","Chen, X.","Barker, B.","Weirauch, M. T.","Jerez, A.","Liu, X.","Makishima, H.","Christie, S.","Starczynowski, D. T.","Rao, D. S.","Fang, J."],"publisher_tesim":["Cell Reports"],"description_tesim":["Chromosome 5q deletions (del[5q]) are common in\nhigh-risk (HR) myelodysplastic syndrome (MDS) and\nacute myeloid leukemia (AML); however, the gene\nregulatory networks that sustain these aggressive\ndiseases are unknown. Reduced miR-146a expression\nin del(5q) HR MDS/AML and miR-146a/ hematopoietic\nstem/progenitor cells (HSPCs) results in\nTRAF6/NF-kB activation. Increased survival and proliferation\nof HSPCs from miR-146alow HR MDS/AML is\nsustained by a neighboring haploid gene, SQSTM1\n(p62), expressed from the intact 5q allele. Overexpression\nof p62 from the intact allele occurs through\nNF-kB-dependent feedforward signaling mediated\nby miR-146a deficiency. p62 is necessary for\nTRAF6-mediated NF-kB signaling, as disrupting the\np62-TRAF6 signaling complex results in cell-cycle arrest\nand apoptosis of MDS/AML cells. Thus, del(5q)\nHR MDS/AML employs an intrachromosomal gene\nnetwork involving loss of miR-146a and haploid overexpression\nof p62 via NF-kB to sustain TRAF6/NF-kB\nsignaling for cell survival and proliferation. Interfering\nwith the p62-TRAF6 signaling complex represents a\ntherapeutic option in miR-146a-deficient and aggressive\ndel(5q) MDS/AML."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2014-09"],"source_tesim":["Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-kB Gene Network"],"thumbnail_path_ss":"/downloads/bc386t10r?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t10r"],"file_set_ids_ssim":["bc386t10r"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"MYELOID MALIGNANCIES WITH CHROMOSOME 5Q DELETIONS ACQUIRE A DEPENDENCY ON AN INTRACHROMOSOMAL NFKB GENE NETWORK","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t090"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697085740469452800,"timestamp":"2021-04-15T06:11:23.425Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":1,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Barker, B.","hits":1,"label":"Barker, B."},{"value":"Bolanos, L.","hits":1,"label":"Bolanos, L."},{"value":"Cancelas, Jose A.","hits":1,"label":"Cancelas, Jose A."},{"value":"Chen, X.","hits":1,"label":"Chen, X."},{"value":"Christie, S.","hits":1,"label":"Christie, S."},{"value":"Fang, J.","hits":1,"label":"Fang, J."}],"label":"Creator Sim"},{"name":"subject_sim","items":[],"label":"Subject Sim"},{"name":"college_sim","items":[{"value":"Medicine","hits":1,"label":"Medicine"}],"label":"College Sim"},{"name":"department_sim","items":[{"value":"Hoxworth Blood Center","hits":1,"label":"Hoxworth Blood Center"}],"label":"Department Sim"},{"name":"language_sim","items":[],"label":"Language Sim"},{"name":"publisher_sim","items":[{"value":"Cell Reports","hits":1,"label":"Cell Reports"}],"label":"Publisher Sim"},{"name":"date_created_sim","items":[{"value":"2014-09","hits":1,"label":"2014-09"}],"label":"Date Created Sim"},{"name":"member_of_collection_ids_ssim","items":[],"label":"Member Of Collection Ids Ssim"},{"name":"generic_type_sim","items":[{"value":"Work","hits":1,"label":"Work"}],"label":"Generic Type Sim"}],"pages":{"current_page":1,"next_page":null,"prev_page":null,"total_pages":1,"limit_value":10,"offset_value":0,"total_count":1,"first_page?":true,"last_page?":true}}}