{"response":{"docs":[{"system_create_dtsi":"2017-10-27T02:51:57Z","system_modified_dtsi":"2018-08-01T18:40:11Z","has_model_ssim":["Article"],"id":"bc387083g","accessControl_ssim":["dcde149e-28a4-44b8-8619-4b9bc785fbde"],"hasRelatedMediaFragment_ssim":["bc387084r"],"hasRelatedImage_ssim":["bc387084r"],"depositor_ssim":["greiskd@ucmail.uc.edu"],"depositor_tesim":["greiskd@ucmail.uc.edu"],"title_tesim":["Refined Structure of the Lipophosphoglycan of Leishmania donovani"],"date_uploaded_dtsi":"2017-03-01T00:00:00Z","date_modified_dtsi":"2017-04-07T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"journal_title_tesim":["Journal of Biological Chemistry"],"college_tesim":["Medicine"],"department_tesim":["Cancer \u0026 Cell Biology"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Ferguson, Michael A. J.","Turco, Salvatore J.","Thomas, Jerry R.","Gorin, Philip A. J.","Homans, Steven W.","McConville, Malcom J.","Greis, Kenneth D.","Thomas-Oates, Jane E."],"subject_tesim":["Biological Chemistry","Biology"],"language_tesim":["English"],"description_tesim":["The primary structure of the major surface glycoconjugate of Leishmania donovani parasites, a lipophosphoglycan, has been further characterized. The repeating PO4-6Galp beta 1-4Man disaccharide units, which are a salient feature of the molecule, are shown to terminate with one of several neutral structures, the most abundant of which is the branched trisaccharide Galp beta 1-4(Manp alpha 1-2)Man. The phosphosaccharide core of lipophosphoglycan, which links the disaccharide repeats to a lipid anchor, contains 2 phosphate residues. One of the core phosphates has previously been localized on O-6 of the galactosyl residue distal to the lipid anchor; the second phosphate is now shown to be on O-6 of the mannosyl residue distal to the anchor and to bear an alpha-linked glucopyranosyl residue. Also, the anomeric configuration of the unusual 3-substituted Galf residue in the phosphosaccharide core is established as beta. The complete structure of the core is thus PO4-6Galp alpha 1-6Galp alpha 1-3Galf beta 1-3[Glcp alpha 1-PO4-6]Manp alpha 1-3Manp alpha 1-4GlcN alpha 1-. This further clarification of the structure of lipophosphoglycan may prove beneficial in determining the structure-function relationships of this highly unusual glycoconjugate."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1992-05"],"source_tesim":["Journal of Biological Chemistry"],"thumbnail_path_ss":"/downloads/bc387084r?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc387084r"],"file_set_ids_ssim":["bc387084r"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"REFINED STRUCTURE OF THE LIPOPHOSPHOGLYCAN OF LEISHMANIA DONOVANI","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["greiskd@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc387083g"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697115499946573824,"timestamp":"2021-04-15T14:04:24.274Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":1,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Ferguson, Michael A. 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