{"response":{"docs":[{"system_create_dtsi":"2017-10-27T02:31:27Z","system_modified_dtsi":"2018-08-01T18:36:55Z","has_model_ssim":["Article"],"id":"bc386t111","accessControl_ssim":["88e34224-a0e1-4419-af18-4ca2a861ad97"],"hasRelatedMediaFragment_ssim":["bc386t129"],"hasRelatedImage_ssim":["bc386t129"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation"],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Inagami, T.","Hill, S. E.","Wellendorf, A. M.","Perumbeti, A.","Nayak, R. C.","Bezold, K. Y.","Zheng, Y.","Chang, K. H.","Pirman, M.","Loberg, A.","Cancelas, Jose A.","Roy, S.","Malik, P.","Starnes, J.","Zhou, X."],"publisher_tesim":["Nature Communication"],"description_tesim":["Patients in organ failure of vascular origin have increased circulating hematopoietic stem cells and\nprogenitors (HSC/P). Plasma levels of angiotensin II (Ang-II), are commonly increased in\nvasculopathies. Hyperangiotensinemia results in activation of a very distinct Ang-II receptor set,\nRho-family GTPase members, and actin in bone marrow endothelial cells (BMEC) and HSC/P,\nwhich results in decreased membrane integrin activation in both BMEC and HSC/P, and in HSC/P\nde-adhesion and mobilization. The Ang-II effect can be reversed pharmacologically and\ngenetically by inhibiting Ang-II production or signaling through BMEC AT2R, HSCP AT1R/\nAT2R or HSC/P RhoA, but not by interfering with other vascular tone mediators.\nHyperangiotensinemia and high counts of circulating HSC/P seen in sickle cell disease (SCD) as a\nresult of vascular damage, is significantly decreased by Ang-II inhibitors. Our data define for the\nfirst time the role of Ang-II HSC/P traffic regulation and redefine the hematopoietic consequences\nof anti-angiotensin therapy in SCD."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2015-01"],"source_tesim":["Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation"],"thumbnail_path_ss":"/downloads/bc386t129?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t129"],"file_set_ids_ssim":["bc386t129"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"VASCULOPATHY ASSOCIATED HYPERANGIOTENSINEMIA MOBILIZES HEMATOPOIETIC STEM CELLSPROGENITORS THROUGH ENDOTHELIAL AT2R AND CYTOSKELETAL DYSREGULATION","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t111"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697103323650326528,"timestamp":"2021-04-15T10:50:52.053Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":1,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Bezold, K. 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