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E.","Wellendorf, A. M.","Perumbeti, A.","Nayak, R. C.","Bezold, K. Y.","Zheng, Y.","Chang, K. H.","Pirman, M.","Loberg, A.","Cancelas, Jose A.","Roy, S.","Malik, P.","Starnes, J.","Zhou, X."],"publisher_tesim":["Nature Communication"],"description_tesim":["Patients in organ failure of vascular origin have increased circulating hematopoietic stem cells and\nprogenitors (HSC/P). Plasma levels of angiotensin II (Ang-II), are commonly increased in\nvasculopathies. Hyperangiotensinemia results in activation of a very distinct Ang-II receptor set,\nRho-family GTPase members, and actin in bone marrow endothelial cells (BMEC) and HSC/P,\nwhich results in decreased membrane integrin activation in both BMEC and HSC/P, and in HSC/P\nde-adhesion and mobilization. The Ang-II effect can be reversed pharmacologically and\ngenetically by inhibiting Ang-II production or signaling through BMEC AT2R, HSCP AT1R/\nAT2R or HSC/P RhoA, but not by interfering with other vascular tone mediators.\nHyperangiotensinemia and high counts of circulating HSC/P seen in sickle cell disease (SCD) as a\nresult of vascular damage, is significantly decreased by Ang-II inhibitors. Our data define for the\nfirst time the role of Ang-II HSC/P traffic regulation and redefine the hematopoietic consequences\nof anti-angiotensin therapy in SCD."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2015-01"],"source_tesim":["Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation"],"thumbnail_path_ss":"/downloads/bc386t129?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t129"],"file_set_ids_ssim":["bc386t129"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"VASCULOPATHY ASSOCIATED HYPERANGIOTENSINEMIA MOBILIZES HEMATOPOIETIC STEM CELLSPROGENITORS THROUGH ENDOTHELIAL AT2R AND CYTOSKELETAL DYSREGULATION","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t111"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697103323650326528,"timestamp":"2021-04-15T10:50:52.053Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:30:50Z","system_modified_dtsi":"2018-08-01T18:37:47Z","has_model_ssim":["Article"],"id":"bc386s921","accessControl_ssim":["2401e49f-fd3b-4480-9937-fce4865c7a21"],"hasRelatedMediaFragment_ssim":["bc386s939"],"hasRelatedImage_ssim":["bc386s939"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Comparison of Approximate Approaches to Solving the Travelling Salesman Problem and its Application to UAV Swarming"],"date_uploaded_dtsi":"2017-02-03T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.14323/ijuseng.2015.1"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Cohen, Kelly","Boone, Nathan","Sathyan, Anoop"],"language_tesim":["English"],"description_tesim":["Comparison of approximate approaches to solving the Travelling Salesman Problem and its application to UAV swarming. International Journal of Unmanned Systems Engineering. 3(1): 1-16. The Travelling Salesman Problem (TSP) is a widely researched Non-deterministic Polynomial-time hard optimization problem with a range of important applications in a wide spectrum of disciplines including aerospace engineering. In this paper, a comparison of different approaches to solve the TSP and also its application towards swarming of UAVs is considered. The objective of the TSP is to determine the optimal route associated with the shortest tour connecting all targets just once. Genetic Algorithms (GA) are one of the most widely applied techniques for solving this class of optimization problems. Two other techniques, 2-opt and Particle Swarm Optimization, are used and the results are compared with those obtained using GA. The comparison is made for different numbers of targets, using salient figures of merit such as computational time required and the cost function which is the minimum solution (distance) obtained. Results show that the 2-opt approach with the closest neighbour as initial starting point for the search yields superior performance. In the Multiple Travelling Salesman Problem, we propose a cluster-first approach which allocates each specific UAV to a subset of targets. The 200 targets are divided into four clusters corresponding to the four UAVs and then TSP algorithms like 2-opt and GA are employed to solve each cluster. This approach drastically reduces the computational time and also gives much better results than the conventional technique of directly applying GA over the 200 targets."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2015-01"],"thumbnail_path_ss":"/downloads/bc386s939?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386s939"],"file_set_ids_ssim":["bc386s939"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"COMPARISON OF APPROXIMATE APPROACHES TO SOLVING THE TRAVELLING SALESMAN PROBLEM AND ITS APPLICATION TO UAV SWARMING","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386s921"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697080682638999552,"timestamp":"2021-04-15T04:50:59.902Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T01:37:53Z","system_modified_dtsi":"2017-11-28T16:58:22Z","has_model_ssim":["Article"],"id":"td96k248x","accessControl_ssim":["a581b89e-98cd-4082-b3a4-babaaa4f230d"],"hasRelatedMediaFragment_ssim":["td96k2496"],"hasRelatedImage_ssim":["td96k2496"],"depositor_ssim":["crowesn@ucmail.uc.edu"],"depositor_tesim":["crowesn@ucmail.uc.edu"],"title_tesim":["Developing a Library Content Services Portal"],"date_uploaded_dtsi":"2015-06-30T00:00:00Z","date_modified_dtsi":"2016-07-27T00:00:00Z","isPartOf_ssim":["admin_set/default"],"journal_title_tesim":["Strategic Library"],"college_tesim":["Libraries"],"department_tesim":["Digital Collections \u0026 Repositories"],"creator_tesim":["Van Mil, James","Crowe, Sean"],"publisher_tesim":["Strategic Library"],"subject_tesim":["Ruby on Rails","Libraries"],"language_tesim":["English"],"description_tesim":["Description of a new web application to support collection development at University of Cincinnati Libraries."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2015-01"],"related_url_tesim":["https://scholar.uc.edu/show/zp38wd50x"],"source_tesim":["Strategic Library"],"thumbnail_path_ss":"/downloads/td96k2496?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["td96k2496"],"file_set_ids_ssim":["td96k2496"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"DEVELOPING A LIBRARY CONTENT SERVICES PORTAL","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["vanmiljf@ucmail.uc.edu","crowesn@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["td96k248x"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697118361035472896,"timestamp":"2021-04-15T14:49:52.821Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":3,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Bezold, K. 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