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Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.\nStat3-mediated modification plays a role in early tumorigenesis."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2016-02"],"source_tesim":["Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. 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Overexpression\nof p62 from the intact allele occurs through\nNF-kB-dependent feedforward signaling mediated\nby miR-146a deficiency. p62 is necessary for\nTRAF6-mediated NF-kB signaling, as disrupting the\np62-TRAF6 signaling complex results in cell-cycle arrest\nand apoptosis of MDS/AML cells. Thus, del(5q)\nHR MDS/AML employs an intrachromosomal gene\nnetwork involving loss of miR-146a and haploid overexpression\nof p62 via NF-kB to sustain TRAF6/NF-kB\nsignaling for cell survival and proliferation. Interfering\nwith the p62-TRAF6 signaling complex represents a\ntherapeutic option in miR-146a-deficient and aggressive\ndel(5q) MDS/AML."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2014-09"],"source_tesim":["Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-kB Gene Network"],"thumbnail_path_ss":"/downloads/bc386t10r?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t10r"],"file_set_ids_ssim":["bc386t10r"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"MYELOID MALIGNANCIES WITH CHROMOSOME 5Q DELETIONS ACQUIRE A DEPENDENCY ON AN INTRACHROMOSOMAL NFKB GENE NETWORK","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t090"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697085740469452800,"timestamp":"2021-04-15T06:11:23.425Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:13Z","system_modified_dtsi":"2018-08-01T18:36:54Z","has_model_ssim":["Article"],"id":"bc386t05w","accessControl_ssim":["aa4e940c-86e9-4afe-9c54-7c92942af259"],"hasRelatedMediaFragment_ssim":["bc386t065"],"hasRelatedImage_ssim":["bc386t065"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["P62 is Required for Stem Cell/Progenitor Retention through Inhahvition of IKK/NF-kB/CcI14 Signaling at the Bone Marrow Macrophage-Osteoblast Niche"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche"],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Moscat, J.","Nayak, R. 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