{"response":{"docs":[{"system_create_dtsi":"2017-10-27T01:06:00Z","system_modified_dtsi":"2019-06-06T15:07:06Z","has_model_ssim":["Article"],"id":"ff365562c","accessControl_ssim":["482cff88-ac68-4f54-b26c-dc4722dab1f6"],"hasRelatedMediaFragment_ssim":["ff365563n"],"hasRelatedImage_ssim":["ff365563n"],"depositor_ssim":["joffritm@ucmail.uc.edu"],"depositor_tesim":["joffritm@ucmail.uc.edu"],"title_tesim":["Sterol biosynthesis and sterol uptake in the funal pathogen Pneumocsytis carinii"],"date_uploaded_dtsi":"2016-04-14T00:00:00Z","date_modified_dtsi":"2016-04-14T00:00:00Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C2NK51"],"college_tesim":["Other"],"department_tesim":["HSL Info \u0026 Edu Svcs"],"creator_tesim":["Grant, Tiffany"],"publisher_tesim":["FEMS Microbiology Letters"],"description_tesim":["Members of the fungal genus Pneumocystis colonize healthy mammalian hosts\nwithout causing apparent disease, but colonization in immunocompromised hosts\nmay result in a potentially fatal pneumonia known as Pneumocystis pneumonia.\nAlthough Pneumocystis are fungi, this genus has characteristics that make it atypical\namong other fungi. Pneumocystis do not appear to synthesize the major fungal sterol,\nergosterol, and biochemical analyses have shown that they utilize cholesterol rather\nthan ergosterol as the bulk sterol. Pneumocystis carinii appears to scavenge exogenous sterols, including cholesterol, from its mammalian host. As a result, it has long been held that their ability to scavenge cholesterol from their hosts, and their inability to undergo sterol biosynthesis, makes them resistant to antifungal drugs that target ergosterol or ergosterol biosynthesis. However, genome scans and in vitro assays indicate the presence of sterol biosynthetic genes within the P. carinii genome, and targeted inhibition of these enzymes resulted in reduced viability of P. carinii,\nsuggesting that these enzymes are functional within the organism. Heterologous\nexpression of P. carinii sterol genes, along with biochemical analyses of the lipid\ncontent of P. carinii cellular membranes, have provided an insight into sterol\nbiosynthesis and the sterol-scavenging mechanisms used by these fungi."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"thumbnail_path_ss":"/downloads/ff365563n?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["ff365563n"],"file_set_ids_ssim":["ff365563n"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"STEROL BIOSYNTHESIS AND STEROL UPTAKE IN THE FUNAL PATHOGEN PNEUMOCSYTIS CARINII","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["joffritm@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["ff365562c"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697102252029771776,"timestamp":"2021-04-15T10:33:50.076Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Article","hits":1,"label":"Article"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Grant, Tiffany","hits":1,"label":"Grant, Tiffany"}],"label":"Creator Sim"},{"name":"subject_sim","items":[],"label":"Subject Sim"},{"name":"college_sim","items":[{"value":"Other","hits":1,"label":"Other"}],"label":"College Sim"},{"name":"department_sim","items":[{"value":"HSL Info \u0026 Edu Svcs","hits":1,"label":"HSL Info \u0026 Edu Svcs"}],"label":"Department Sim"},{"name":"language_sim","items":[],"label":"Language Sim"},{"name":"publisher_sim","items":[{"value":"FEMS Microbiology Letters","hits":1,"label":"FEMS Microbiology Letters"}],"label":"Publisher Sim"},{"name":"date_created_sim","items":[],"label":"Date Created Sim"},{"name":"member_of_collection_ids_ssim","items":[],"label":"Member Of Collection Ids Ssim"},{"name":"generic_type_sim","items":[{"value":"Work","hits":1,"label":"Work"}],"label":"Generic Type Sim"}],"pages":{"current_page":1,"next_page":null,"prev_page":null,"total_pages":1,"limit_value":10,"offset_value":0,"total_count":1,"first_page?":true,"last_page?":true}}}