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Pneumocystis do not appear to synthesize the major fungal sterol,\nergosterol, and biochemical analyses have shown that they utilize cholesterol rather\nthan ergosterol as the bulk sterol. Pneumocystis carinii appears to scavenge exogenous sterols, including cholesterol, from its mammalian host. As a result, it has long been held that their ability to scavenge cholesterol from their hosts, and their inability to undergo sterol biosynthesis, makes them resistant to antifungal drugs that target ergosterol or ergosterol biosynthesis. However, genome scans and in vitro assays indicate the presence of sterol biosynthetic genes within the P. carinii genome, and targeted inhibition of these enzymes resulted in reduced viability of P. carinii,\nsuggesting that these enzymes are functional within the organism. Heterologous\nexpression of P. carinii sterol genes, along with biochemical analyses of the lipid\ncontent of P. carinii cellular membranes, have provided an insight into sterol\nbiosynthesis and the sterol-scavenging mechanisms used by these fungi."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"thumbnail_path_ss":"/downloads/ff365563n?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["ff365563n"],"file_set_ids_ssim":["ff365563n"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"STEROL BIOSYNTHESIS AND STEROL UPTAKE IN THE FUNAL PATHOGEN PNEUMOCSYTIS CARINII","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["joffritm@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["ff365562c"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697102252029771776,"timestamp":"2021-04-15T10:33:50.076Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Image","hits":4797,"label":"Image"},{"value":"Dataset","hits":3723,"label":"Dataset"},{"value":"Etd","hits":994,"label":"Etd"},{"value":"Document","hits":980,"label":"Document"},{"value":"Article","hits":967,"label":"Article"},{"value":"Student Work","hits":756,"label":"Student Work"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Snider, Jerry A. 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