{"response":{"docs":[{"system_create_dtsi":"2019-03-06T17:28:06Z","system_modified_dtsi":"2021-04-16T14:56:47Z","has_model_ssim":["Document"],"id":"b5644s654","accessControl_ssim":["5862c667-fa75-4e0e-8ef3-19af03d61462"],"hasRelatedMediaFragment_ssim":["3t945r88s"],"hasRelatedImage_ssim":["3t945r88s"],"depositor_ssim":["schmiddr@ucmail.uc.edu"],"depositor_tesim":["schmiddr@ucmail.uc.edu"],"title_tesim":["Multivariate Public Key Cryptosystems"],"date_uploaded_dtsi":"2019-03-06T17:28:06Z","date_modified_dtsi":"2020-08-12T19:17:25Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/5sqr-g734"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["- Computing Sciences \u0026 Informatics"],"creator_tesim":["Schmidt, Dieter Sam","Petzoldt, Albrecht","Ding, Jintai"],"publisher_tesim":["University of Cincinnati"],"description_tesim":["Programs used and described in the book \"Multivariate Public Key Cryptosystems\" by Ding, Petzoldt and Schmidt.   All programs can be downloaded via the attached zip file.  Modify the file \"startup.txt\"  so that the base directory  matches your setup. Put this file where magma can find it. \r\n After starting magma  run:  load \"startup.txt\";   It will then allow you to select the method on which you want to work.\r\n\r\n\r\nFiles can be downloaded individually by clicking on a chapter name and then selecting the scheme of interest.\r\n"],"license_tesim":["http://creativecommons.org/publicdomain/mark/1.0/"],"source_tesim":["b5644s654"],"thumbnail_path_ss":"/assets/work-ff055336041c3f7d310ad69109eda4a887b16ec501f35afc0a547c4adb97ee72.png","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["0k225b94v","0g354g08r","0c483m090","2801ph54m","6t053g89c","3t945r88s","vm40xs59m","pn89d7644","sf268653c"],"file_set_ids_ssim":["0k225b94v","0g354g08r","0c483m090","2801ph54m","6t053g89c","3t945r88s","vm40xs59m","pn89d7644","sf268653c"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"MULTIVARIATE PUBLIC KEY CRYPTOSYSTEMS","human_readable_type_tesim":["Document"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["schmiddr@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["b5644s654"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697209393578246144,"timestamp":"2021-04-16T14:56:48.219Z","score":0.00049999997},{"system_create_dtsi":"2019-03-01T05:47:51Z","system_modified_dtsi":"2019-06-06T15:12:41Z","has_model_ssim":["Document"],"id":"n009w3506","accessControl_ssim":["b3829d82-8265-4b4b-9984-6c5497850169"],"hasRelatedMediaFragment_ssim":["dv13zv41w"],"hasRelatedImage_ssim":["dv13zv41w"],"depositor_ssim":["angelwr@mail.uc.edu"],"depositor_tesim":["angelwr@mail.uc.edu"],"title_tesim":["Dark Knowledge: A Study on Public Perceptions of the Dark Web"],"date_uploaded_dtsi":"2019-03-01T05:47:51Z","date_modified_dtsi":"2019-03-01T05:47:51Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C27M5N"],"alternate_title_tesim":["Dark Knowledge: Public Perceptions of the Dark Web"],"genre_tesim":["Document"],"time_period_tesim":["21st Century"],"college_tesim":["Education, Criminal Justice, and Human Services"],"department_tesim":["School of Information Technology"],"creator_tesim":["Angel, William"],"publisher_tesim":["University of Cincinnati"],"subject_tesim":["Information Technology","Black Market","Cyber Security","Dark Web"],"language_tesim":["English"],"description_tesim":["In this paper, I study how general technology users perceive the dark web. In this study, \r\nI conducted research on what these users know about dark web technologies, activities, \r\ncontent, and how their perceptions changed after a first-hand experience on dark web \r\nmarketplaces and sites. I aimed to tackle myths and misconceptions that users had about the \r\ndark web and present new data in order to educate and bring awareness to the dark web to \r\nthose who may never have the opportunity or reason to come upon this information on their \r\nown. It is my hope that the findings of this paper and the experiences of the participants will \r\nfoster the spread of knowledge and awareness to both the threats and benefits that the dark \r\nweb contributes to society. "],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2018-12-13"],"thumbnail_path_ss":"/downloads/dv13zv41w?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["dv13zv41w"],"file_set_ids_ssim":["dv13zv41w"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"DARK KNOWLEDGE A STUDY ON PUBLIC PERCEPTIONS OF THE DARK WEB","human_readable_type_tesim":["Document"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["angelwr@mail.uc.edu"],"nesting_collection__pathnames_ssim":["n009w3506"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697114531394748416,"timestamp":"2021-04-15T13:49:00.591Z","score":0.00049999997},{"system_create_dtsi":"2019-02-17T15:38:21Z","system_modified_dtsi":"2019-05-23T16:10:11Z","has_model_ssim":["Article"],"id":"x059c851q","accessControl_ssim":["c1765be4-5e25-42a3-8a56-1e3d848bab59"],"hasRelatedMediaFragment_ssim":["j098zc28c"],"hasRelatedImage_ssim":["j098zc28c"],"depositor_ssim":["marinesa@ucmail.uc.edu"],"depositor_tesim":["marinesa@ucmail.uc.edu"],"title_tesim":["How We Got to the Same Place (Almost): the Universality of the Music Called \"Jazz\""],"date_uploaded_dtsi":"2019-02-17T15:38:21Z","date_modified_dtsi":"2019-05-23T16:10:11Z","isPartOf_ssim":["admin_set/default"],"time_period_tesim":["21st Century","20th Century"],"college_tesim":["Libraries"],"department_tesim":["University Of Cincinnati Libraries (UCL)"],"creator_tesim":["Marine, Stephen","Grier, Melvin"],"publisher_tesim":["University of Cincinnati"],"subject_tesim":["Jazz","Music"],"language_tesim":["English"],"description_tesim":["A conversation between two friends who are not musicians and whose personal histories could hardly be more different. Through a series of conversations we explored those journeys, compared and contrasted our stories, and discussed just why this music affects us so deeply. We discussed specific musicians in terms of whether we liked, did not like, or were indifferent to their music, and why we either agreed or not. In these conversations we posed various questions to each other, hoping to discover and articulate certain essences that we might share. One thing we agreed upon up front is that we are neither musicians nor music critics. In fact, we’re not convinced that the field of music criticism is even a valid endeavor. Music description and personal reaction, however, is another matter. In our conversations we tried to describe our reactions to specific musicians and “schools” of music, without labeling the music as “good” or “lousy”. You will see that this doesn’t prevent us from disagreeing and disagreeing in spirited fashion, while always trying to focus on why our personal reaction is what it is."],"license_tesim":["http://creativecommons.org/licenses/by/4.0/"],"date_created_tesim":["2019-01"],"thumbnail_path_ss":"/downloads/j098zc28c?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["j098zc28c"],"file_set_ids_ssim":["j098zc28c"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"HOW WE GOT TO THE SAME PLACE ALMOST THE UNIVERSALITY OF THE MUSIC CALLED JAZZ","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["marinesa@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["x059c851q"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697107041067204608,"timestamp":"2021-04-15T11:49:57.258Z","score":0.00049999997},{"system_create_dtsi":"2019-02-06T19:45:51Z","system_modified_dtsi":"2019-05-23T18:42:47Z","has_model_ssim":["Article"],"id":"gm80hw40g","accessControl_ssim":["7ca9901a-19f9-4b2d-b1f1-6667fd8d5141"],"hasRelatedMediaFragment_ssim":["cc08hg77b"],"hasRelatedImage_ssim":["cc08hg77b"],"depositor_ssim":["krukowsa@ucmail.uc.edu"],"depositor_tesim":["krukowsa@ucmail.uc.edu"],"title_tesim":["Parallel Projections"],"date_uploaded_dtsi":"2019-02-06T19:45:51Z","date_modified_dtsi":"2019-05-23T18:42:47Z","isPartOf_ssim":["admin_set/default"],"geo_subject_tesim":["Ohio","Iowa"],"journal_title_tesim":["Drawing On"],"time_period_tesim":["Contemporary"],"college_tesim":["Design, Architecture, Art and Planning"],"department_tesim":["School of Design"],"creator_tesim":["Goché, Peter","Krukowski, Samantha"],"publisher_tesim":["University of Edinburgh"],"subject_tesim":["Architecture, Art, Agriculture, Urban Impact, Video Installation, Industry, Post-Industrial, Abandonment, History"],"language_tesim":["English"],"description_tesim":["Parallel Projections investigates two types of postindustrial site: the architectural and the agricultural; it conflates (projections of and into) spaces as means of making visceral our intellectual comprehension of the\r\nrelationships between materiality, surface, place and history. Parallel Projections is not meant for specific\r\nplaces but for specific kinds of spaces: defunct industrial buildings, abandoned urban edifices, and mechanized\r\nnatural landscapes. The authors, living in places (Iowa and Ohio) that have both been radically altered by scalar\r\neconomic shifts, adapt alien (guest) project components to their native (host) contexts. Both types of spaces, host\r\nand guest, as spaces of urban and rural abandonment, share surfaces that are compelling palimpsests. These\r\nsurfaces are encrusted with nearly-obliterated histories, emptied by changes in production methods and habits\r\nof occupation and revealed by ghost texts. In opposition to the idea that these sites should be whitewashed and redrawn, the authors see them as grounds for new layers that can receive projections of phenomena from other postindustrial sites and as repositories for material evidence that deepens, rather than erases, the evidence of their\r\npasts."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2018-05"],"related_url_tesim":["http://drawingon.org/issue/02?fbclid=IwAR14GE-uYZslhtew6K-R6r68hSLM-zAaO3Xn4l8leGSoN4jeFXmKU4tNVFA"],"source_tesim":["Drawing On"],"thumbnail_path_ss":"/downloads/cc08hg77b?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["cc08hg77b"],"file_set_ids_ssim":["cc08hg77b"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"PARALLEL PROJECTIONS","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["krukowsa@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["gm80hw40g"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697104017494114304,"timestamp":"2021-04-15T11:01:53.754Z","score":0.00049999997},{"system_create_dtsi":"2019-02-06T19:35:25Z","system_modified_dtsi":"2019-05-23T15:33:11Z","has_model_ssim":["Article"],"id":"1c18dg87t","accessControl_ssim":["0e06ff20-5d76-4d3c-8062-5f13a2f77d80"],"hasRelatedMediaFragment_ssim":["cj82k839c"],"hasRelatedImage_ssim":["cj82k839c"],"depositor_ssim":["krukowsa@ucmail.uc.edu"],"depositor_tesim":["krukowsa@ucmail.uc.edu"],"title_tesim":["On the Substance of Absence: Filling the Historical Void"],"date_uploaded_dtsi":"2019-02-06T19:35:25Z","date_modified_dtsi":"2019-05-23T15:33:11Z","isPartOf_ssim":["admin_set/default"],"geo_subject_tesim":["New York, NY"],"time_period_tesim":["20th Century"],"college_tesim":["Design, Architecture, Art and Planning"],"department_tesim":["School of Design"],"creator_tesim":["Krukowski, Samantha"],"publisher_tesim":["University of Cincinnati"],"language_tesim":["English"],"description_tesim":["A 1948 exhibition catalogue of the work of Alberto Giacommetti, with an essay by Jean-Paul Sartre, highlights the relationships between sculpture and psychoanalysis, phenomenology, existentialism."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1994"],"thumbnail_path_ss":"/downloads/cj82k839c?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["cj82k839c"],"file_set_ids_ssim":["cj82k839c"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"ON THE SUBSTANCE OF ABSENCE FILLING THE HISTORICAL VOID","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["krukowsa@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["1c18dg87t"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697105484590350336,"timestamp":"2021-04-15T11:25:12.886Z","score":0.00049999997},{"system_create_dtsi":"2019-02-05T21:30:59Z","system_modified_dtsi":"2019-06-06T15:04:45Z","has_model_ssim":["Document"],"id":"rr171z33v","accessControl_ssim":["de038863-1e17-4505-aeaf-734d10aca824"],"hasRelatedMediaFragment_ssim":["4x51hk15c"],"hasRelatedImage_ssim":["4x51hk15c"],"depositor_ssim":["joffritm@ucmail.uc.edu"],"depositor_tesim":["joffritm@ucmail.uc.edu"],"title_tesim":["Researcher Services: Proposal to Increase Distinctive Excellence"],"date_uploaded_dtsi":"2019-02-05T21:30:59Z","date_modified_dtsi":"2019-02-05T21:30:59Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C2TM5X"],"college_tesim":["Libraries"],"department_tesim":["HSL Info \u0026 Edu Svcs"],"creator_tesim":["Koshoffer, Amy","Baldwin, Ted","Burgess, Kristen","Grant, Tiffany"],"publisher_tesim":["University of Cincinnati","University of Cincinnati Libraries "],"description_tesim":["This document details our process for creating a service catalog for UC Libraries Research and Data Services and our efforts towards offering data science services. In this document, we identify our gaps in knowledge and expertise while making recommendations for filling these gaps. \r\n"],"license_tesim":["http://creativecommons.org/licenses/by-nc/4.0/"],"thumbnail_path_ss":"/downloads/4x51hk15c?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["4x51hk15c"],"file_set_ids_ssim":["4x51hk15c"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"RESEARCHER SERVICES PROPOSAL TO INCREASE DISTINCTIVE EXCELLENCE","human_readable_type_tesim":["Document"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["joffritm@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["rr171z33v"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697096686589968384,"timestamp":"2021-04-15T09:05:22.459Z","score":0.00049999997},{"system_create_dtsi":"2019-02-05T17:08:40Z","system_modified_dtsi":"2021-04-16T14:56:52Z","has_model_ssim":["Document"],"id":"gh93h078b","accessControl_ssim":["1591a933-44a0-433a-a79f-1695daefe27b"],"hasRelatedMediaFragment_ssim":["gx41mk04m"],"hasRelatedImage_ssim":["gx41mk04m"],"depositor_ssim":["howesr@ucmail.uc.edu"],"depositor_tesim":["howesr@ucmail.uc.edu"],"title_tesim":["Strategies for Increasing Home Ownership in the City of Cincinnati"],"date_uploaded_dtsi":"2019-02-05T17:08:40Z","date_modified_dtsi":"2019-05-23T16:31:21Z","isPartOf_ssim":["admin_set/default"],"geo_subject_tesim":["Cincinnati, OH"],"genre_tesim":["Document"],"time_period_tesim":["Late 20th Century"],"college_tesim":["Arts and Sciences"],"department_tesim":["Psychology"],"creator_tesim":["Howe, Steven"],"publisher_tesim":["University of Cincinnati"],"subject_tesim":["Urban Planning"],"language_tesim":["English"],"license_tesim":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"date_created_tesim":["1996-12"],"source_tesim":["gh93h078b"],"thumbnail_path_ss":"/downloads/gx41mk04m?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["gx41mk04m"],"file_set_ids_ssim":["gx41mk04m"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"STRATEGIES FOR INCREASING HOME OWNERSHIP IN THE CITY OF CINCINNATI","human_readable_type_tesim":["Document"],"read_access_group_ssim":["public"],"edit_access_group_ssim":["admin"],"edit_access_person_ssim":["howesr@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["gh93h078b"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697209398463561728,"timestamp":"2021-04-16T14:56:52.878Z","description_tesim":["Cincinnati has one of the lowest home ownership rates in the country for cities of comparable size. Several other cities with low rates of home ownership in 1970 have managed to increase their rates two to four percent over the past 25 years, but the home ownership rate in Cincinnati has been stable over that period at 38 percent.\r\n\r\nThe best explanation for Cincinnati’s low home ownership rate is that the topography of the city encouraged dense development involving multiple-unit structures up until World War II. When the highway programs of the post-war period opened up the suburbs to development, the city was already built-out and could not compete for new single-unit construction that the federal government was subsidizing on a massive scale.\r\n\r\nIn the last 50 years, the Hamilton County suburbs have gained 140,000 owners while the number of owners in the city has decreased by 1,000. As a result, the home ownership rate in the Cincinnati metropolitan area is greater than the national rate for areas of comparable size (63 percent versus 61 percent) while the rate in the city is far less than the national rate.\r\n\r\nThe City of Cincinnati faces a number of challenges in any effort to increase its home ownership rate. Government programs in other cities typically produce dozens of units a year, not the hundreds of units that Cincinnati needs to produce. In order to achieve even a modest increase in home ownership, the city will have to alter market forces in the direction of increased supply of housing suitable for owner-occupancy and increased demand for home ownership.\r\n\r\nIn order to increase its rate of home ownership to 41 percent by the year 2010, the City of Cincinnati needs to adopt a four-part strategy:\r\n\r\nIncrease the Supply of Units\r\nThe market cannot produce new units on its own. The city needs to assemble and prepare sites in order to reduce the additional costs associated with building in the city as opposed to the suburbs. City Hall must continue to eliminate barriers to development and provide new services to builders. Cincinnati will not be able to increase the number of middle-class owners without creating new neighborhood areas with the appropriate mix of amenities. At the lower end of the owner-market, the city needs to move aggressively to convert abandoned structures into units people will want to buy and rehabilitate.\r\n\r\nHelp Renters Become Owners\r\nWhile converting renters to owners is an essential component of an overall strategy, the City of Cincinnati must recognize that not everyone can be an owner and target its resources appropriately. The city does not have unlimited funds to change the cost equation of owning a home and will, therefore, have to learn from other cities how to work with lending institutions to increase the flow of dollars under Community Reinvestment Act initiatives. Other cities have had some limited success with programs to convert people renting duplex and condo units into owners. The city needs to increase the availability, extent and quality of education and counseling programs. \r\n\r\nAttract New Households to the City\r\nThe city has to market its neighborhoods, and in some cases, smaller areas within neighborhoods. This will require market research, training programs for Realtors, investments in street furniture, increased services, publications extolling city neighborhoods, and programs comparable to the Living in Cleveland program. The city needs to start working cooperatively with the Cincinnati Public Schools. Specific market niches in which the city can hope to compete very successfully include the empty nesters, the gay and lesbian community, first time buyers, and people interested in downtown living.\r\n\r\nMaintain the Existing Pool of Owners\r\nAbout 75 percent of the time a home owner in Cincinnati sells and buys another home in the Cincinnati area, the home purchased will be in the suburbs. The city must create opportunities for the home seller to move up without moving out of the city.\r\n\r\nIn addition to the above strategies, which involve the central city market, the City of Cincinnati needs to actively promote strategies that will help slow the rate of suburbanization and that will create low income housing opportunities in the suburbs. If suburbanization continues at the current rate, and if the city continues to be the governmental unit with de facto responsibility for low income housing, there is every reason to wonder if there is anything that the city can do to increase its rate of home ownership.\r\n"],"score":0.00049999997},{"system_create_dtsi":"2019-01-23T19:09:20Z","system_modified_dtsi":"2019-05-23T18:40:25Z","has_model_ssim":["Document"],"id":"6t053g883","accessControl_ssim":["957bc231-d4fa-4a59-949b-4624af8c3036"],"hasRelatedMediaFragment_ssim":["6w924d08k"],"hasRelatedImage_ssim":["6w924d08k"],"depositor_ssim":["robertrl@ucmail.uc.edu"],"depositor_tesim":["robertrl@ucmail.uc.edu"],"title_tesim":["EndNote X8 Workbook"],"date_uploaded_dtsi":"2019-01-23T19:09:20Z","date_modified_dtsi":"2019-05-23T18:40:25Z","isPartOf_ssim":["admin_set/default"],"genre_tesim":["Document"],"college_tesim":["Libraries"],"department_tesim":["Research, Teaching \u0026 Services"],"creator_tesim":["Roberts, Randall"],"publisher_tesim":["University of Cincinnati"],"subject_tesim":["EndNote","Citation \u0026 Reference Management"],"description_tesim":["This document is a workshop workbook for EndNote X8, a citation and reference management software product. 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Holokai et al., 2018"],"date_uploaded_dtsi":"2018-12-21T20:49:29Z","date_modified_dtsi":"2018-12-21T21:10:11Z","isPartOf_ssim":["admin_set/default"],"doi_tesim":["doi:10.7945/C2Q120"],"college_tesim":["Medicine"],"department_tesim":["Department of Pharmacology and Systems Physiology"],"required_software_tesim":[""],"note_tesim":[""],"creator_tesim":["Zavros, Yana"],"publisher_tesim":["University of Cincinnati"],"description_tesim":["ABSTRACT\r\nHelicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer.  Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis.  H. pylori also induces programmed death ligand 1 (PD-L1) expression on gastric epithelial cells, yet the mechanism is unknown.  We hypothesize that H. pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Shh signaling pathway during infection.  To identify the role of Shh signaling as a mediator of H. pylori-induced PD-L1 expression, human gastric organoids generated from either induced pluripotent stem cells (HGOs) or tissue (huFGOs) were microinjected with bacteria and treated with Hedgehog/Gli inhibitor GANT61. Gastric epithelial monolayers generated from the huFGOs were also infected with H. pylori and treated with GANT61 to study the role of Hedgehog signaling as a mediator of induced PD-1 expression. A patient-derived organoid/autologous immune cell co-culture system infected with H. pylori and treated with PD-1 inhibitor (PD-1Inh) was developed to study the protective mechanism of PD-L1 in response to bacterial infection. H. pylori significantly increased PD-L1 expression in organoid cultures 48 hours post-infection when compared to uninfected controls.  The mechanism was cytotoxic associated gene A (CagA) dependent.  This response was blocked by pretreatment with GANT61.  Anti-PD-L1 treatment of H. pylori infected huFGOs, co-cultured with autologous patient cytotoxic T lymphocytes and dendritic cells, induced organoid death.  H. pylori-induced PD-L1 expression is mediated by the Shh signaling pathway within the gastric epithelium. 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