{"response":{"docs":[{"system_create_dtsi":"2017-10-27T02:32:15Z","system_modified_dtsi":"2018-08-01T18:37:55Z","has_model_ssim":["Article"],"id":"bc386t332","accessControl_ssim":["01d921be-5b19-47dd-bdb4-122031633251"],"hasRelatedMediaFragment_ssim":["bc386t34b"],"hasRelatedImage_ssim":["bc386t34b"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Control of Linear Second-Order Systems by Fuzzy Logic-Based Algorithm"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.2514/2.4738"],"journal_title_tesim":["Journal Of Guidance, Control, And Dynamics"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Weller, Tanchum","Cohen, Kelly","Ben-Asher, Joseph Z."],"language_tesim":["English"],"description_tesim":["The control of  exible structures employing the passivity approach has been extended to systems having noncollocated input/output pairs by introducing an observer that incorporates the nominal dynamical model of the plant. The passive observer-based control is applied to the American Control Conference benchmark problem, whereby, the control force emulates a dynamic vibration absorber attached to a virtual wall with passive control elements (spring, mass, and dashpot). The springs and mass elements of the controller are constant, whereas the damping coefŽ cients are selected as time dependent in an attempt to choose continuously the most appropriate amount of damping in compliance with the design goals. A novel approach is introduced, whereby the passive observer-based control law is modiŽ ed by varying the damping coefŽ cient of the virtual dashpot by means of an adaptive fuzzy logic algorithm. This modiŽ ed system exhibits quick settling times and desirable performance characteristics. Results from the statistical robustness analysis for the developed controller are compared to 10 other (linear) solutionsof the benchmarkproblem. The comparisonis based onrobust stability, robust performance (settling time), and control effort. The results obtained by the adaptive fuzzy logic algorithm are superior to those obtained by all other methods, and, consequently, further application of the fuzzy algorithm is advocated."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2001-06"],"source_tesim":["Journal Of Guidance, Control, And Dynamics"],"thumbnail_path_ss":"/downloads/bc386t34b?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t34b"],"file_set_ids_ssim":["bc386t34b"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"CONTROL OF LINEAR SECONDORDER SYSTEMS BY FUZZY LOGICBASED ALGORITHM","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t332"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697122201502744576,"timestamp":"2021-04-15T15:50:55.376Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:32:11Z","system_modified_dtsi":"2018-08-01T18:37:54Z","has_model_ssim":["Article"],"id":"bc386t31h","accessControl_ssim":["d713d6bc-d6cc-46c5-90e6-f0310b2e821c"],"hasRelatedMediaFragment_ssim":["bc386t32s"],"hasRelatedImage_ssim":["bc386t32s"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Model-Independent Vibration Control of Flexible Beam-Like Structures Using a Fuzzy Based Adaptation Strategy"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1177/1045389X9700800304"],"journal_title_tesim":["Journal of Intelligent Material Systems and Structures"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Abramovich, Haim","Weller, T.","Cohen, Kelly","Levitas, Joseph"],"language_tesim":["English"],"description_tesim":["The present study deals with an AFCA (Adaptive Fuzzy Control Algorithm) for an Euler-Bernoulli approximation of a two-dimensional version of a cantilever beam-like orthogonal tetrahedral space truss. Transient disturbances, modeled as a unit impulse, excite all the modes of the beam. The resulting transverse displacement at the free end of the beam and its corresponding rate are observed by sensors placed there, and active control of the beam is provided by a collocated force actuator.\n\nA design methodology for the closed-loop control algorithm that is independent of an exact mathematical model (space-state model, F.E.M., etc.) of plant dynamics and which is based on fuzzy logic is presented. First, the behavior of the open-loop system is observed. Then, the control force applied to the system emulates the behavior of a dynamic vibration absorber which is tuned to the measured fundamental frequency. This approach not only assures inherent stability associated with passive absorbers, but also circumvents the phenomenon of modal spillover. The damping and the mass ratios of the absorber adapt themselves by using a fuzzy decision-making process. This results in relatively quick settling times, low overshoots and dying out of vibration within a few seconds.\n\nWhen the control force is turned off after a mere 16 seconds, almost all the vibrational energy is dissipated. In addition, the performance of the AFCA is insensitive to varying initial conditions. To demonstrate the robustness of the control system to changes in the temporal dynamics of the cantilever beam, the transient response to a considerably perturbed plant is simulated. The Young's modulus of the beam was raised as well as lowered substantially, thereby significantly perturbing the natural frequencies of vibration. The mode shapes, however, remain unchanged. For these cases, too, the AFCA provides similar settling times and rates of vibrational energy dissipation."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1997-03"],"source_tesim":["Journal of Intelligent Material Systems and Structures"],"thumbnail_path_ss":"/downloads/bc386t32s?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t32s"],"file_set_ids_ssim":["bc386t32s"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"MODELINDEPENDENT VIBRATION CONTROL OF FLEXIBLE BEAMLIKE STRUCTURES USING A FUZZY BASED ADAPTATION STRATEGY","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t31h"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697073736834875392,"timestamp":"2021-04-15T03:00:35.867Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:32:07Z","system_modified_dtsi":"2018-08-01T18:37:45Z","has_model_ssim":["Article"],"id":"bc386t29g","accessControl_ssim":["4ec369e2-d654-4d10-a36d-6e0440aa83a7"],"hasRelatedMediaFragment_ssim":["bc386t307"],"hasRelatedImage_ssim":["bc386t307"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["An Adaptive Fuzzy Control Algorithm for Model-Independent Active Vibration Damping of Flexible Beam-Like Structures"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1177/1045389X9600700208"],"journal_title_tesim":["Journal of Intelligent Material Systems and Structures"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Abramovich, Haim","Weller, Tanchum","Cohen, Kelly","Levitas, Joseph"],"language_tesim":["English"],"description_tesim":["The present study deals with an AFCA (Adaptive Fuzzy Control Algorithm) for an Euler-Bemoulli approximation of a two-dimensional version of a cantilever beam-like orthogonal tetrahedral space truss. Transient disturbances, modeled as a unit impulse, excite all the modes of the beam. The resulting transverse displacement at the free end of the beam and its corresponding rate are observed by sensors placed there, and active control of the beam is provided by a collocated force actuator.\n\nA design methodology, based on fuzzy logic which assumes no a priori knowledge of plant dynamics, for the closed-loop control algorithm results in relatively quick settling times, low overshoots and dying out of vibration within a few seconds. The control algorithm is enhanced and made much faster by eliminating the need of repeatedly solving the set of differential equations of motion of an emulated dynamic vibration absorber. When the control force is turned off after a mere 15 seconds, almost all the vibrational energy is dissipated as the beam returns to its undisturbed state throughout its length. In addition, the performance of the AFCA is insensitive to varying initial conditions. To examine the robustness of the control system to changes in the temporal dynamics of the cantilever beam, the transient disturbance response to a considerably perturbed plant is simulated. The Young's modulus of the beam was raised as well as lowered by 60%, substantially perturbing the natural frequencies of vibration compared to the nominal plant. The AFCA provided similar settling times and rates of vibrational energy dissipation, satisfying the aim of plant model independence."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1996-03"],"source_tesim":["Journal of Intelligent Material Systems and Structures"],"thumbnail_path_ss":"/downloads/bc386t307?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t307"],"file_set_ids_ssim":["bc386t307"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"ADAPTIVE FUZZY CONTROL ALGORITHM FOR MODELINDEPENDENT ACTIVE VIBRATION DAMPING OF FLEXIBLE BEAMLIKE STRUCTURES","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t29g"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697125529301286912,"timestamp":"2021-04-15T16:43:49.012Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:32:03Z","system_modified_dtsi":"2018-08-01T18:37:53Z","has_model_ssim":["Article"],"id":"bc386t27x","accessControl_ssim":["2f463021-8328-40e0-8bee-e4a9ea42f2cf"],"hasRelatedMediaFragment_ssim":["bc386t286"],"hasRelatedImage_ssim":["bc386t286"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Passive Damping Augmentation for Vibration Suppression in Flexible Latticed Beam-Like Space Structures"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1006/jsvi.1994.1332"],"journal_title_tesim":["Journal of Sound and Vibration"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Weller, T.","Cohen, Kelly"],"language_tesim":["English"],"description_tesim":["For a Timoshenko beam model the equations of motion, representing the anisotropic continuum model of a two-dimensional, latticed, large space structure, are extended to include coupling between the extensional, shear and bending modes. This analytical model, applied to a 20-bay, orthogonal, tetrahedral, cantilevered truss structure, is used to determine the transient response when subjected to a unit impulse. It is demonstrated that for beam-like structures having a fixed bending stiffness and beam mass an increase in diagonal stiffness, on account of the stiffness of the vertical girder, leads to a rise in the transverse shear rigidity. This results in higher natural frequencies and a reduction in peak displacement. In addition, in an asymmetrical truss configuration, coupling between the extensional and shear modes raises the maximum peak displacement compared to that obtained for a symmetric truss. The model is modified to investigate the introduction of passive damping in the form of several dynamic vibration absorbers. For a fixed absorber mass budget, a simple yet efficient absorber parameter optimization procedure, based on the classical steady state criteria of a 2-DOF system, is developed to design several absorbers each tuned to a different modal frequency. It is found that inclusion of transverse shear rigidity, as a design parameter in damping augmentation studies, reduces settling time for predetermined maximum peak displacements."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["1994-08"],"source_tesim":["Journal of Sound and Vibration"],"thumbnail_path_ss":"/downloads/bc386t286?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t286"],"file_set_ids_ssim":["bc386t286"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"PASSIVE DAMPING AUGMENTATION FOR VIBRATION SUPPRESSION IN FLEXIBLE LATTICED BEAMLIKE SPACE STRUCTURES","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t27x"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697095641371508736,"timestamp":"2021-04-15T08:48:45.661Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:58Z","system_modified_dtsi":"2018-08-01T18:37:44Z","has_model_ssim":["Article"],"id":"bc386t25c","accessControl_ssim":["88ca0d3e-4175-4fde-9a42-b11161c690bf"],"hasRelatedMediaFragment_ssim":["bc386t26n"],"hasRelatedImage_ssim":["bc386t26n"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Genetic Fuzzy based Artificial Intelligence for Unmanned Combat Aerial Vehicle Control in Simulated Air Combat Missions"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.4172/2167-0374.1000144"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Schumacher, Corey","Cohen, Kelly","Ernest, Nicholas","Carroll, David","Lee, Gene","Clark, Matthew"],"language_tesim":["English"],"description_tesim":["Breakthroughs in genetic fuzzy systems, most notably the development of the Genetic Fuzzy Tree methodology, have allowed fuzzy logic based Artificial Intelligences to be developed that can be applied to incredibly complex problems. The ability to have extreme performance and computational efficiency as well as to be robust to uncertainties and randomness, adaptable to changing scenarios, verified and validated to follow safety specifications and operating doctrines via formal methods, and easily designed and implemented are just some of the strengths that this type of control brings. Within this white paper, the authors introduce ALPHA, an Artificial Intelligence that controls flights of Unmanned Combat Aerial Vehicles in aerial combat missions within an extreme-fidelity simulation environment. To this day, this represents the most complex application of a fuzzy-logic based Artificial Intelligence to an Unmanned Combat Aerial Vehicle control problem. While development is on-going, the version of ALPHA presented withinwas assessed by Colonel (retired)Gene Lee who described ALPHA as “the most aggressive, responsive, dynamic and credible AI (he’s) seen-to-date.” The quality of these preliminary results in a problem that is not only complex and rife with uncertainties but also contains an intelligent and unrestricted hostile force has significant implications for this type of Artificial Intelligence. This work adds immensely to the body of evidence that this methodology is an ideal solution to a very wide array of problems."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2016-03"],"thumbnail_path_ss":"/downloads/bc386t26n?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t26n"],"file_set_ids_ssim":["bc386t26n"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"GENETIC FUZZY BASED ARTIFICIAL INTELLIGENCE FOR UNMANNED COMBAT AERIAL VEHICLE CONTROL IN SIMULATED AIR COMBAT MISSIONS","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t25c"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697097296531947520,"timestamp":"2021-04-15T09:15:04.145Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:54Z","system_modified_dtsi":"2018-08-01T18:37:43Z","has_model_ssim":["Article"],"id":"bc386t23t","accessControl_ssim":["447c00b2-27b4-4100-b654-0cd1929629f9"],"hasRelatedMediaFragment_ssim":["bc386t243"],"hasRelatedImage_ssim":["bc386t243"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Spatio-temporal Estimation Of Wildfire Growth"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1115/DSCC2013-4022"],"journal_title_tesim":["Proceedings of the ASME Dynamic Systems and Control Conference"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Sharma, Balaji R.","Cohen, Kelly","Kumar, Manish"],"language_tesim":["English"],"description_tesim":["This work presents a methodology for real-time estimation of wildland fire growth, utilizing afire growth model based on a set of partial differential equations for prediction, and harnessing concepts of space-time Kalman filtering and Proper Orthogonal Decomposition techniques towards low dimensional estimation of potentially large spatio-temporal states. The estimation framework is discussed in its criticality towards potential applications such as forest fire surveillance with unmanned systems equipped with onboard sensor suites. The effectiveness of the estimation process is evaluated numerically over fire growth data simulated using a well-established fire growth model described by coupled partial differential equations. The methodology is shown to be fairly accurate in estimating spatio-temporal process states through noise-ridden measurements for real-time deploy ability."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2013-10"],"source_tesim":["Proceedings of the ASME Dynamic Systems and Control Conference"],"thumbnail_path_ss":"/downloads/bc386t243?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t243"],"file_set_ids_ssim":["bc386t243"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"SPATIOTEMPORAL ESTIMATION OF WILDFIRE GROWTH","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t23t"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697092934966444032,"timestamp":"2021-04-15T08:05:44.632Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:50Z","system_modified_dtsi":"2018-08-01T18:36:53Z","has_model_ssim":["Article"],"id":"bc386t218","accessControl_ssim":["c91331db-617b-4f94-ae8c-b34824a36652"],"hasRelatedMediaFragment_ssim":["bc386t22j"],"hasRelatedImage_ssim":["bc386t22j"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["Lack of Communication Rusts and Ages Stem Cells"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["Landes Bio Science "],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Cancelas, Jose A.","Taniguchi, E."],"publisher_tesim":["Landes Bio Science "],"description_tesim":["Not Available."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2012-09-01"],"source_tesim":["Landes Bio Science "],"thumbnail_path_ss":"/downloads/bc386t22j?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t22j"],"file_set_ids_ssim":["bc386t22j"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"LACK OF COMMUNICATION RUSTS AND AGES STEM CELLS","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t218"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697087855610822656,"timestamp":"2021-04-15T06:45:00.581Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:46Z","system_modified_dtsi":"2018-08-01T18:37:48Z","has_model_ssim":["Article"],"id":"bc386t197","accessControl_ssim":["a1cd563e-1560-4fa8-a3ac-e406e192dd95"],"hasRelatedMediaFragment_ssim":["bc386t200"],"hasRelatedImage_ssim":["bc386t200"],"depositor_ssim":["cohenky@ucmail.uc.edu"],"depositor_tesim":["cohenky@ucmail.uc.edu"],"title_tesim":["Integration of Computations and Experiments for Flow Control Research With Undergraduate Students"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-05T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["dungavjk@mail.uc.edu"],"doi_tesim":["10.1002/cae.20278"],"journal_title_tesim":["Computer Applications in Engineering Education"],"college_tesim":["Engineering and Applied Science"],"department_tesim":["Aerospace Engineering and Engineering Mechanics"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Cohen, Kelly","McLaughlin, Thomas","Seaver, Christopher A.","Aradag, Selin"],"language_tesim":["English"],"description_tesim":["The methods and outcome of a senior undergraduate project related to the control of a turbulent cylinder wake flow using plasma actuators are summarized in this article. The study integrates computational fluid dynamics (CFD) with experimentation and combines fluid mechanics with flow control research, crossing the boundaries between engineering disciplines.Comput. Appl. Eng. Educ."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2009-02"],"source_tesim":["Computer Applications in Engineering Education"],"thumbnail_path_ss":"/downloads/bc386t200?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t200"],"file_set_ids_ssim":["bc386t200"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"INTEGRATION OF COMPUTATIONS AND EXPERIMENTS FOR FLOW CONTROL RESEARCH WITH UNDERGRADUATE STUDENTS","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"read_access_person_ssim":["konecnmc@ucmail.uc.edu"],"edit_access_person_ssim":["cohenky@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t197"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697095008051527680,"timestamp":"2021-04-15T08:38:41.680Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:41Z","system_modified_dtsi":"2018-08-01T18:36:51Z","has_model_ssim":["Article"],"id":"bc386t17p","accessControl_ssim":["5d36fa68-f895-4b5c-806f-3a1ca9ee812c"],"hasRelatedMediaFragment_ssim":["bc386t18z"],"hasRelatedImage_ssim":["bc386t18z"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["Insertional Mutagenesis Identifies a STAT3/Arid1b/ b-catenin Pathway Driving Neurofibroma Initiation"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis."],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Spinner, R. J.","Ratner, N.","Largaespada, D. A.","Keng, V.","Patmore, D. M.","Wu, J.","Cancelas, Jose A."],"publisher_tesim":["Cell Reports"],"description_tesim":["Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates\nNeurofibromatosis type 1 (Nf1) neurofibromas, using unbiased\ninsertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.\nStat3-mediated modification plays a role in early tumorigenesis."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2016-02"],"source_tesim":["Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis."],"thumbnail_path_ss":"/downloads/bc386t18z?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t18z"],"file_set_ids_ssim":["bc386t18z"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"INSERTIONAL MUTAGENESIS IDENTIFIES A STAT3ARID1B BCATENIN PATHWAY DRIVING NEUROFIBROMA INITIATION","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t17p"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697108570496040960,"timestamp":"2021-04-15T12:14:15.834Z","score":0.00049999997},{"system_create_dtsi":"2017-10-27T02:31:35Z","system_modified_dtsi":"2018-08-01T18:36:52Z","has_model_ssim":["Article"],"id":"bc386t154","accessControl_ssim":["6e878354-fc4f-4bd4-a562-4360c50abe48"],"hasRelatedMediaFragment_ssim":["bc386t16d"],"hasRelatedImage_ssim":["bc386t16d"],"depositor_ssim":["cancelje@ucmail.uc.edu"],"depositor_tesim":["cancelje@ucmail.uc.edu"],"title_tesim":["PM-18 EGFR-STAT3 Activates B-Catenin Signaling to Drive Neurofibroma Initiation in Nf1, and Plays a Role in Tumor Maintenance"],"date_uploaded_dtsi":"2017-02-08T00:00:00Z","date_modified_dtsi":"2017-04-10T00:00:00Z","isPartOf_ssim":["admin_set/default"],"proxy_depositor_ssim":["peckjd@mail.uc.edu"],"journal_title_tesim":["PM-18. EGFR-STAT3 ACTIVATES b-CATENIN SIGNALING TO DRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A ROLE IN TUMOR MAINTENANCE Nancy Ratner1, Vincent Keng2, Deanna M. Patmore1, Jed K. Kendall1, Edwin Jousma1, Kwangmin Choi1, Danhua Fan2, Eric B. Schwartz2, James R. Fuchs2, Yuanshu Zou2, Mi-Ok Kim1, Eva Dombi5, David E. Levy6, Jose A. Cancelas1, Anat Stemmer-Rachamimov4, Robert J. Spinner3, and David A. Largaespada2; 1 Cincinnati Children’s, Cincinnati, OH, USA; 2 University of Minnesota, Minneapolis, MN, USA; 3 Mayo Clinic, Rochester, MN, USA; 4 Massachusetts General Hospital, Boston, MA, USA; 5 National Cancer Institute Pediatric Branch, Bethesda, MD, USA; 6 New York University School of Medicine, New York, NY, USA To identify genes and signaling pathways that drive peripheral nerve tumor initiationand growth beyond the Ras-MAPK pathwaywe used unbiased insertional mutagenesis screening. We identified Stat3 as a potential driver of Neurofibromatosis type 1 neurofibroma. Targeted genetic deletion of Stat3 in Schwann cell precursors (SCPs) and Schwann cells (SCs) largely prevented neurofibroma formation, and self-renewal of tumor initiating cells. Genetic gain- and loss-of-function identified EGFR as the major upstream regulator of P-Stat3 in mouse and human neurofibroma SCP and in neurofibroma initiation; IL-6 reinforced EGFR/Jak/Stat signaling. Preclinical tests of a Jak2/ Stat3 inhibitor reduced established neurofibroma growth, supporting an additional role for Stat3 in benign nerve tumor maintenance. Unexpectedly, downstream of Stat3, we identified b-catenin, and b-catenin expression rescued phenotypic effects of Stat3 loss in SCPs. Phosphorylated STAT3 (Y705) and b-catenin were strongly correlated in NF1 human plexiform neurofibromas. The data support testing of JAK/STAT inhibition and Wnt/ b-catenin pathway inhibition in neurofibroma therapeutic trials. Supported by: NIH R01 NS28840 to N.R. and NIH P50 NS057531 to N.R. and D.L.), a DAMD New Investigator Award (W81XWH-11-1-0259) and an Ohio State University Comprehensive Cancer Center Pelotonia Idea Grant (to J.W.). The American Cancer Society (IRG-67-003-44) supported J.R.F."],"college_tesim":["Medicine"],"department_tesim":["Hoxworth Blood Center"],"note_tesim":["This work was part of a pilot \"mediated-deposit model\" where library staff found potential works, later submitted for faculty review"],"creator_tesim":["Schwartz, E. B.","Ratner, N.","Largaespada, D. A.","Cancelas, Jose A.","Stemmer-Rachamimov, A. O."],"publisher_tesim":["Neuro-Oncology"],"description_tesim":["PM-18. EGFR-STAT3 ACTIVATES b-CATENIN SIGNALING TO\nDRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A\nROLE IN TUMOR MAINTENANCE\nNancy Ratner1, Vincent Keng2, Deanna M. Patmore1, Jed K. Kendall1,\nEdwin Jousma1, Kwangmin Choi1, Danhua Fan2, Eric B. Schwartz2, James\nR. Fuchs2, Yuanshu Zou2, Mi-Ok Kim1, Eva Dombi5, David E. Levy6, Jose\nA. Cancelas1, Anat Stemmer-Rachamimov4, Robert J. Spinner3, and David\nA. Largaespada2;\n1\nCincinnati Children’s, Cincinnati, OH, USA; 2\nUniversity of\nMinnesota, Minneapolis, MN, USA; 3\nMayo Clinic, Rochester, MN, USA; 4\nMassachusetts General Hospital, Boston, MA, USA; 5\nNational Cancer\nInstitute Pediatric Branch, Bethesda, MD, USA; 6\nNew York University School\nof Medicine, New York, NY, USA\nTo identify genes and signaling pathways that drive peripheral nerve tumor\ninitiationand growth beyond the Ras-MAPK pathwaywe used unbiased insertional\nmutagenesis screening. We identified Stat3 as a potential driver of\nNeurofibromatosis type 1 neurofibroma. Targeted genetic deletion of Stat3\nin Schwann cell precursors (SCPs) and Schwann cells (SCs) largely prevented\nneurofibroma formation, and self-renewal of tumor initiating cells. Genetic\ngain- and loss-of-function identified EGFR as the major upstream regulator\nof P-Stat3 in mouse and human neurofibroma SCP and in neurofibroma initiation;\nIL-6 reinforced EGFR/Jak/Stat signaling. Preclinical tests of a Jak2/\nStat3 inhibitor reduced established neurofibroma growth, supporting an additional\nrole for Stat3 in benign nerve tumor maintenance. Unexpectedly, downstream\nof Stat3, we identified b-catenin, and b-catenin expression rescued\nphenotypic effects of Stat3 loss in SCPs. Phosphorylated STAT3 (Y705) and\nb-catenin were strongly correlated in NF1 human plexiform neurofibromas.\nThe data support testing of JAK/STAT inhibition and Wnt/ b-catenin\npathway inhibition in neurofibroma therapeutic trials. Supported by: NIH\nR01 NS28840 to N.R. and NIH P50 NS057531 to N.R. and D.L.), a\nDAMD New Investigator Award (W81XWH-11-1-0259) and an Ohio State\nUniversity Comprehensive Cancer Center Pelotonia Idea Grant (to J.W.).\nThe American Cancer Society (IRG-67-003-44) supported J.R.F."],"license_tesim":["http://rightsstatements.org/vocab/InC/1.0/"],"date_created_tesim":["2014-11"],"source_tesim":["PM-18. EGFR-STAT3 ACTIVATES b-CATENIN SIGNALING TO DRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A ROLE IN TUMOR MAINTENANCE Nancy Ratner1, Vincent Keng2, Deanna M. Patmore1, Jed K. Kendall1, Edwin Jousma1, Kwangmin Choi1, Danhua Fan2, Eric B. Schwartz2, James R. Fuchs2, Yuanshu Zou2, Mi-Ok Kim1, Eva Dombi5, David E. Levy6, Jose A. Cancelas1, Anat Stemmer-Rachamimov4, Robert J. Spinner3, and David A. Largaespada2; 1 Cincinnati Children’s, Cincinnati, OH, USA; 2 University of Minnesota, Minneapolis, MN, USA; 3 Mayo Clinic, Rochester, MN, USA; 4 Massachusetts General Hospital, Boston, MA, USA; 5 National Cancer Institute Pediatric Branch, Bethesda, MD, USA; 6 New York University School of Medicine, New York, NY, USA To identify genes and signaling pathways that drive peripheral nerve tumor initiationand growth beyond the Ras-MAPK pathwaywe used unbiased insertional mutagenesis screening. We identified Stat3 as a potential driver of Neurofibromatosis type 1 neurofibroma. Targeted genetic deletion of Stat3 in Schwann cell precursors (SCPs) and Schwann cells (SCs) largely prevented neurofibroma formation, and self-renewal of tumor initiating cells. Genetic gain- and loss-of-function identified EGFR as the major upstream regulator of P-Stat3 in mouse and human neurofibroma SCP and in neurofibroma initiation; IL-6 reinforced EGFR/Jak/Stat signaling. Preclinical tests of a Jak2/ Stat3 inhibitor reduced established neurofibroma growth, supporting an additional role for Stat3 in benign nerve tumor maintenance. Unexpectedly, downstream of Stat3, we identified b-catenin, and b-catenin expression rescued phenotypic effects of Stat3 loss in SCPs. Phosphorylated STAT3 (Y705) and b-catenin were strongly correlated in NF1 human plexiform neurofibromas. The data support testing of JAK/STAT inhibition and Wnt/ b-catenin pathway inhibition in neurofibroma therapeutic trials. Supported by: NIH R01 NS28840 to N.R. and NIH P50 NS057531 to N.R. and D.L.), a DAMD New Investigator Award (W81XWH-11-1-0259) and an Ohio State University Comprehensive Cancer Center Pelotonia Idea Grant (to J.W.). The American Cancer Society (IRG-67-003-44) supported J.R.F."],"thumbnail_path_ss":"/downloads/bc386t16d?file=thumbnail","suppressed_bsi":false,"actionable_workflow_roles_ssim":["admin_set/default-default-depositing"],"workflow_state_name_ssim":["deposited"],"member_ids_ssim":["bc386t16d"],"file_set_ids_ssim":["bc386t16d"],"visibility_ssi":"open","admin_set_tesim":["Default Admin Set"],"sort_title_ssi":"PM18 EGFRSTAT3 ACTIVATES BCATENIN SIGNALING TO DRIVE NEUROFIBROMA INITIATION IN NF1 AND PLAYS A ROLE IN TUMOR MAINTENANCE","human_readable_type_tesim":["Article"],"read_access_group_ssim":["public"],"edit_access_person_ssim":["cancelje@ucmail.uc.edu"],"nesting_collection__pathnames_ssim":["bc386t154"],"nesting_collection__deepest_nested_depth_isi":1,"_version_":1697125337642565632,"timestamp":"2021-04-15T16:40:46.232Z","score":0.00049999997}],"facets":[{"name":"human_readable_type_sim","items":[{"value":"Image","hits":4797,"label":"Image"},{"value":"Dataset","hits":3723,"label":"Dataset"},{"value":"Etd","hits":994,"label":"Etd"},{"value":"Document","hits":979,"label":"Document"},{"value":"Article","hits":963,"label":"Article"},{"value":"Student Work","hits":755,"label":"Student Work"}],"label":"Human Readable Type Sim"},{"name":"creator_sim","items":[{"value":"Snider, Jerry A. (senior collector)","hits":3484,"label":"Snider, Jerry A. (senior collector)"},{"value":"Tepe, Eric (record/image)","hits":3484,"label":"Tepe, Eric (record/image)"},{"value":"Huston, Ron","hits":2344,"label":"Huston, Ron"},{"value":"He, Si (co-collector)","hits":1093,"label":"He, Si (co-collector)"},{"value":"Meyer, David L.","hits":631,"label":"Meyer, David L."},{"value":"Davis, Jack","hits":611,"label":"Davis, Jack"}],"label":"Creator Sim"},{"name":"subject_sim","items":[{"value":"Kingdom: Plantae","hits":3453,"label":"Kingdom: Plantae"},{"value":"Phylum: Bryophyta","hits":3146,"label":"Phylum: Bryophyta"},{"value":"Class: Bryopsida","hits":2902,"label":"Class: Bryopsida"},{"value":"Biology","hits":2361,"label":"Biology"},{"value":"Order: Hypnales","hits":1190,"label":"Order: Hypnales"},{"value":"Order: Dicranales","hits":369,"label":"Order: Dicranales"}],"label":"Subject Sim"},{"name":"college_sim","items":[{"value":"Arts and Sciences","hits":6145,"label":"Arts and Sciences"},{"value":"Engineering and Applied Science","hits":2769,"label":"Engineering and Applied Science"},{"value":"Design, Architecture, Art and Planning","hits":1235,"label":"Design, Architecture, Art and Planning"},{"value":"Other","hits":1070,"label":"Other"},{"value":"Libraries","hits":666,"label":"Libraries"},{"value":"Education, Criminal Justice, and Human Services","hits":541,"label":"Education, Criminal Justice, and Human Services"}],"label":"College Sim"},{"name":"department_sim","items":[{"value":"Biological Sciences","hits":3503,"label":"Biological Sciences"},{"value":"Mechanical and Materials Engineering","hits":2264,"label":"Mechanical and Materials Engineering"},{"value":"Other","hits":992,"label":"Other"},{"value":"Simpson Center for Urban Futures ","hits":784,"label":"Simpson Center for Urban Futures "},{"value":"Classics","hits":769,"label":"Classics"},{"value":"Romance \u0026 Arabic Languages \u0026 Literat","hits":644,"label":"Romance \u0026 Arabic Languages \u0026 Literat"}],"label":"Department Sim"},{"name":"language_sim","items":[{"value":"English","hits":1951,"label":"English"},{"value":"en_US","hits":224,"label":"en_US"},{"value":"English ","hits":145,"label":"English "},{"value":"Russian","hits":34,"label":"Russian"},{"value":"Spanish","hits":24,"label":"Spanish"},{"value":"German","hits":19,"label":"German"}],"label":"Language Sim"},{"name":"publisher_sim","items":[{"value":"University of Cincinnati, Margaret H. Fulford Herbarium (CINC)","hits":3484,"label":"University of Cincinnati, Margaret H. Fulford Herbarium (CINC)"},{"value":"University of Cincinnati","hits":3005,"label":"University of Cincinnati"},{"value":"University of Cincinnati: Romance and Arabic Languages and Literatures","hits":603,"label":"University of Cincinnati: Romance and Arabic Languages and Literatures"},{"value":"University of Cincinnati ","hits":100,"label":"University of Cincinnati "},{"value":"viDEO sAVant","hits":92,"label":"viDEO sAVant"},{"value":"Benjamin Britton","hits":60,"label":"Benjamin Britton"}],"label":"Publisher Sim"},{"name":"date_created_sim","items":[{"value":"2017","hits":2305,"label":"2017"},{"value":"","hits":211,"label":""},{"value":"2001-03-31","hits":181,"label":"2001-03-31"},{"value":"2017-10-31","hits":163,"label":"2017-10-31"},{"value":"2001-03-30","hits":156,"label":"2001-03-30"},{"value":"2001-03-29","hits":127,"label":"2001-03-29"}],"label":"Date Created Sim"},{"name":"member_of_collection_ids_ssim","items":[{"value":"1r66j250c","hits":3484,"label":"1r66j250c"},{"value":"79407x47z","hits":2123,"label":"79407x47z"},{"value":"05741w32f","hits":341,"label":"05741w32f"},{"value":"bc3871882","hits":225,"label":"bc3871882"},{"value":"x346d4806","hits":219,"label":"x346d4806"},{"value":"bc387z838","hits":189,"label":"bc387z838"}],"label":"Member Of Collection Ids Ssim"},{"name":"generic_type_sim","items":[{"value":"Work","hits":12573,"label":"Work"},{"value":"Collection","hits":171,"label":"Collection"}],"label":"Generic Type Sim"}],"pages":{"current_page":1099,"next_page":1100,"prev_page":1098,"total_pages":1275,"limit_value":10,"offset_value":10980,"total_count":12744,"first_page?":false,"last_page?":false}}}