Index Catalog // Scholar@UC

Start Over

Filtering by: College Medicine Creator/Author Haffey, Wendy D. Date Created 2014-09 Department Cancer & Cell Biology

1 entry found

Type:: Article
Description/Abstract:: Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2. Results: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome. Conclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome. Significance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease).
Creator/Author:: Haffey, Wendy D.; Grabowski, Gregory A.; Greis, Kenneth D., and Llou, Benjamin
Submitter:: Kenneth Greis
Date Uploaded:: 03/03/2017
Date Modified:: 04/07/2017
Date Created:: 2014-09

Search Constraints