Robert Ross brings to light ninety-eight foundational texts of Khoesan political thought and highlights the voices of the Khoesan people and their inspiring history of resistance in the face of colonial oppression.
With the several changes happening every day in societies and in thoughts say knowledge challenges are increasing day by day which is to be faced by business as well as other organizations. To tackle these challenges many tactics are implemented and are in process to further improve. Handling of these challenges requires a system under which one can work and let adaptation to the changes can be done smoothly. Today majority of business organizations have a knowledge management program in one or another form. Indian business organizations are also feeling the need for new business paradigms. Knowledge management is a systematic process for creating, acquiring, synthesizing, learning, sharing and using knowledge and experience to achieve organizational goals. This paper “Handling Knowledge in Indian Information Technology (IT) Organizations” underscores Knowledge Management practices in business organizations at main cities in India. Papers site an overview of the techniques and also include future improvements that can be done to ameliorate the efficiency of Knowledge Management System.
From the Temple of Zeus to the Hyperloop: University of Cincinnati Stories celebrates the bicentennial anniversary of the University of Cincinnati with over thirty-five personal stories that highlight the university's transformative and inspiring history.
Fungi in the genus Pneumocystis are the cause of a potentially life threatening
pneumonia, Pneumocystis pneumonia (PCP). The understanding of the lifecycle, metabolism, and drug development has been hindered due to a lack of a long term in vitro culture system. Unlike most other fungi, members of the genus Pneumocystis do not appear to synthesize the major fungal sterol, ergosterol. However, genome scans and in vitro assays suggest the presence of functional genes involved in a sterol pathway. One of the goals of this work was to characterize the P. carinii sterol enzyme, lanosterol synthase (Erg7p), an essential enzyme of the sterol pathway. The activity of P. carinii Erg7p was assessed by heterologous expression of P. carinii Erg7p in a Saccharomyces cerevisiae Erg7p null mutant. Growth rates and lanosterol production were similar between S. cerevisiae expressing the P. carinii enzyme and S. cerevisiae expressing its own Erg7p under the same conditions, indicating that not only does P. carinii produce a functional Erg7p, but also that the enzyme functionally complements the S. cerevisiae enzyme. Western blotting and fluorescent localization studies revealed that P. carinii Erg7p localizes to lipid particles in S. cerevisiae as does S. cerevisiae Erg7p. A novel finding of these studies, was that P. carinii contains lipid particles, and that P. carinii Erg7p localizes to lipid particles in P. carinii. These studies indicate that P. carinii Erg7p functions similar to the S. cerevisiae enzyme, and may perform a similar function in P. carinii.
Biochemical analyses of sterols within the membranes of P. carinii have shown that it utilizes cholesterol rather than ergosterol as its bulk sterol. However, P. carinii does not appear to synthesize cholesterol from a de novo pathway, but rather scavenges
exogenous sterols from its mammalian host. S. cerevisiae is induced to undergo sterol
scavenging under anaerobic conditions. Consequently, another goal of this work was to provide information on the effect of O2 on sterol biosynthesis and sterol scavenging by P. carinii. ATP measurements revealed that the viability of P. carinii is severely decreased when maintained under hypoxic conditions, and this decrease correlated with an increase in drug susceptibility. We show that uptake of exogenous cholesterol by P. carinii occurred under normal O2 tensions, indicating that sterol scavenging is not limited to anaerobic conditions. Microarray analysis indicated that hypoxic maintenance of P. carinii resulted in decreased transcription of several genes involved in sterol and lipid biosynthesis suggesting that while hypoxic conditions down-regulated genes involved in sterol biosynthesis, down-regulation of sterol biosynthesis is not a requirement for sterol scavenging in P. carinii. The ability of P. carinii to scavenge exogenous sterols under normal O2 tensions at which the sterol pathway is unaffected provides evidence that sterol scavenging may be the primary means that P. carinii utilizes to obtain its sterols.
Dr. Deborah Duran is the director of NIMHD’s Office of Science Policy, Strategic Planning, Analysis, Reporting, and Data (OSPARD). She has 20 years of experience in organizational strategic planning, system assessments, science policy, measures, metrics, data management, performance monitoring, and reporting. Dr. Duran leads two branches within OSPARD: Science Planning, Policy, and Reporting; and Data, Assessments, Resources, and Evaluation. OSPARD serves NIMHD planning, assessment, analysis, and reporting needs and coordinates trans-NIH minority health and health disparities planning and reporting requirements. Dr. Duran hopes to help NIMHD become the centralized source of minority health and health disparities biomedical data, policies, and scientific advances.
Dr. Duran has spent much of her NIH career serving as performance director in the NIH Office of the Director, handling a wide range of responsibilities, including program performance monitoring, budget performance integration, organization performance assessments, and strategic planning. She designed a centralized online reporting system, currently used by NIH and the U.S. Department of Health and Human Services (HHS), to assist in the collection, analysis, and communication of organization performance information.
Dr. Duran trained in social psychology and virus research, statistics, evaluation, counseling, and computer science. She has experience as an educator, principal investigator, advocate, researcher, consultant, and counselor. Her areas of interest include system science, population health, Hispanic health, behavior research, cancer, coping, end-of-life care, palliative care, data systems, data management, and training minority youth.
Dr. Duran has a Ph.D. in social psychology with a minor in research methodologies and statistics. In 2000 and in 2004, Dr. Duran earned the HHS Secretary’s Award for Distinguished Service.
This was the morning keynote for the 4th Annual UC Data Day Conference hosted by UC Libraries.
The keynote presenter was Amanda J. Wilson, Head, National Network Coordinating Office, National Library of Medicine, All of Us Research Program partner
This talk was the first panelist in the Health Equities and Disparities Session for the 4th Annual UC Data Day Conference hosted by UC Libraries.
Reem Aly, JD, MHA, Health Policy Institute of Ohio
Talk Title: Closing Ohio’s health gaps: Moving towards equity
Reem Aly is the Vice President of Healthcare System and Innovation Policy at the Health Policy Institute of Ohio. Aly leads work on current and emerging health policy issues related to healthcare system and access, healthcare spending, social determinants of health and equity. She co-leads development of HPIO’s Health Value Dashboard and is currently leading HPIO’s contracted work to develop the state’s Maternal and Child Health and Maternal, Infant and Early Childhood Home Visiting Assessments.