This dataset shows the quantities and findspots of coins minted by the ancient mint(s) at Antioch on the Orontes in northern Syria. The kml files are usable in Google Earth. Coin finds are sorted by material (bronze, silver, antoniniani), type (provincial SC, provincial silver and misc. bronze, civic coins with imperial portrait, civic coins without imperial portrait), and chronology (223 BCE-91 BCE, 90 BCE-31 BCE, 30 BCE-235 CE, 236 CE-283 CE, 284 CE-423 CE).
For the original publication of this data, see the attached appendix.
Robert Ross brings to light ninety-eight foundational texts of Khoesan political thought and highlights the voices of the Khoesan people and their inspiring history of resistance in the face of colonial oppression.
With the several changes happening every day in societies and in thoughts say knowledge challenges are increasing day by day which is to be faced by business as well as other organizations. To tackle these challenges many tactics are implemented and are in process to further improve. Handling of these challenges requires a system under which one can work and let adaptation to the changes can be done smoothly. Today majority of business organizations have a knowledge management program in one or another form. Indian business organizations are also feeling the need for new business paradigms. Knowledge management is a systematic process for creating, acquiring, synthesizing, learning, sharing and using knowledge and experience to achieve organizational goals. This paper “Handling Knowledge in Indian Information Technology (IT) Organizations” underscores Knowledge Management practices in business organizations at main cities in India. Papers site an overview of the techniques and also include future improvements that can be done to ameliorate the efficiency of Knowledge Management System.
From the Temple of Zeus to the Hyperloop: University of Cincinnati Stories celebrates the bicentennial anniversary of the University of Cincinnati with over thirty-five personal stories that highlight the university's transformative and inspiring history.
Organisms in the genus Pneumocystis are ubiquitous, opportunistic pathogenic fungi capable of causing a
lethal pneumonia in immunocompromised mammalian hosts. Pneumocystis spp. are unique members of the
fungal kingdom due to the absence of ergosterol in their cellular membranes. Although these organisms were
thought to obtain cholesterol by scavenging, transcriptional analyses indicate that Pneumocystis carinii encodes
gene homologs involved in sterol biosynthesis. To better understand the sterol pathway in these uncultivable
fungi, yeast deletion strains were used to interrogate the function and localization of P. carinii lanosterol synthase (ERG7). The expression of PcErg7p in an ERG7-null mutant of the yeast Saccharomyces cerevisiae did not alter its growth rate and produced a functional lanosterol synthase, as evidenced by the presence of
lanosterol detected by gas chromatographic analysis in levels comparable to that produced by the yeast enzyme. Western blotting and fluorescence microscopy revealed that, like the S. cerevisiae Erg7p, the PcErg7p localized to lipid particles in yeast. Using fluorescence microscopy, we show for the first time the presence of apparent lipid particles in P. carinii and the localization of PcErg7p to lipid particles in P. carinii. The detection of lipid particles in P. carinii and their association with PcErg7p therein provide strong evidence that the enzyme serves a similar function in P. carinii. Moreover, the yeast heterologous system should be a useful tool for further analysis of the P. carinii sterol pathway.
Members of the fungal genus Pneumocystis colonize healthy mammalian hosts
without causing apparent disease, but colonization in immunocompromised hosts
may result in a potentially fatal pneumonia known as Pneumocystis pneumonia.
Although Pneumocystis are fungi, this genus has characteristics that make it atypical
among other fungi. Pneumocystis do not appear to synthesize the major fungal sterol,
ergosterol, and biochemical analyses have shown that they utilize cholesterol rather
than ergosterol as the bulk sterol. Pneumocystis carinii appears to scavenge exogenous sterols, including cholesterol, from its mammalian host. As a result, it has long been held that their ability to scavenge cholesterol from their hosts, and their inability to undergo sterol biosynthesis, makes them resistant to antifungal drugs that target ergosterol or ergosterol biosynthesis. However, genome scans and in vitro assays indicate the presence of sterol biosynthetic genes within the P. carinii genome, and targeted inhibition of these enzymes resulted in reduced viability of P. carinii,
suggesting that these enzymes are functional within the organism. Heterologous
expression of P. carinii sterol genes, along with biochemical analyses of the lipid
content of P. carinii cellular membranes, have provided an insight into sterol
biosynthesis and the sterol-scavenging mechanisms used by these fungi.
Fungi in the genus Pneumocystis are the cause of a potentially life threatening
pneumonia, Pneumocystis pneumonia (PCP). The understanding of the lifecycle, metabolism, and drug development has been hindered due to a lack of a long term in vitro culture system. Unlike most other fungi, members of the genus Pneumocystis do not appear to synthesize the major fungal sterol, ergosterol. However, genome scans and in vitro assays suggest the presence of functional genes involved in a sterol pathway. One of the goals of this work was to characterize the P. carinii sterol enzyme, lanosterol synthase (Erg7p), an essential enzyme of the sterol pathway. The activity of P. carinii Erg7p was assessed by heterologous expression of P. carinii Erg7p in a Saccharomyces cerevisiae Erg7p null mutant. Growth rates and lanosterol production were similar between S. cerevisiae expressing the P. carinii enzyme and S. cerevisiae expressing its own Erg7p under the same conditions, indicating that not only does P. carinii produce a functional Erg7p, but also that the enzyme functionally complements the S. cerevisiae enzyme. Western blotting and fluorescent localization studies revealed that P. carinii Erg7p localizes to lipid particles in S. cerevisiae as does S. cerevisiae Erg7p. A novel finding of these studies, was that P. carinii contains lipid particles, and that P. carinii Erg7p localizes to lipid particles in P. carinii. These studies indicate that P. carinii Erg7p functions similar to the S. cerevisiae enzyme, and may perform a similar function in P. carinii.
Biochemical analyses of sterols within the membranes of P. carinii have shown that it utilizes cholesterol rather than ergosterol as its bulk sterol. However, P. carinii does not appear to synthesize cholesterol from a de novo pathway, but rather scavenges
exogenous sterols from its mammalian host. S. cerevisiae is induced to undergo sterol
scavenging under anaerobic conditions. Consequently, another goal of this work was to provide information on the effect of O2 on sterol biosynthesis and sterol scavenging by P. carinii. ATP measurements revealed that the viability of P. carinii is severely decreased when maintained under hypoxic conditions, and this decrease correlated with an increase in drug susceptibility. We show that uptake of exogenous cholesterol by P. carinii occurred under normal O2 tensions, indicating that sterol scavenging is not limited to anaerobic conditions. Microarray analysis indicated that hypoxic maintenance of P. carinii resulted in decreased transcription of several genes involved in sterol and lipid biosynthesis suggesting that while hypoxic conditions down-regulated genes involved in sterol biosynthesis, down-regulation of sterol biosynthesis is not a requirement for sterol scavenging in P. carinii. The ability of P. carinii to scavenge exogenous sterols under normal O2 tensions at which the sterol pathway is unaffected provides evidence that sterol scavenging may be the primary means that P. carinii utilizes to obtain its sterols.
Poster presented at the 2016 Lilly Conference on evidence-based teaching and learning in Traverse City, Michigan.
A major goal of higher education is to help students choose purposeful pathways through college as they acquire skills that support them in becoming self-regulated and lifelong learners. This poster describes the successful implementation of two practices that foster self-regulated learning, a before- and after-course case study used to assess course knowledge and goal setting, in a fully online teacher education course. In addition to describing the practices, the poster includes a thematic analysis of the data from open-ended student responses to the assignment. Participants are invited to discuss the implications of this work and its potential applications in their classrooms.
After interacting with others at this poster, you will be able to: (a) describe two practices for developing self-regulated learners, (b) identify lessons learned from the implementation of these practices in a fully online teacher education course, and (c) apply these practices to one of your own courses.
This dataset shows the origins and quantities of coins found through excavations at Antioch. Data can be examined by material (bronze, silver, antoniniani, and uncertain) and chronology (223 BCE to 91 BCE, 90 BCE to 31 BCE, 30 BCE to 235 CE, 236 CE to 283 CE, 284 CE to 423 CE). All data is from Waage, D. B. 1952. Antioch-on-the-Orontes: Committee for the Excavation of Antioch and its Vicinity 4.2: Greek, Roman, Byzantine and Crusader’s Coins, Princeton.
Starting or growing a co-op/internship program can be intimidating; for both educators and potential
employer partners. In an effort to learn the pain points for both parties, opportunities to break down
barriers and build bridges, and identify actionable steps to get started, faculty from the University of
Cincinnati’s Division of Experience-Based Learning and Career Education conducted a two-year research
project with 65 co-op and internship employers from more 15 unique industry clusters, and 50
university faculty and staff representing 24 unique institutions. This poster will graphically share the
resulting findings from more than 1250 qualitative responses, and generate discussion on the
educational pedagogy of creating best practices for employer partners. Find out what “the survey says”!
Hyperelastic constitutive models of soft tissue mechanical behavior are extensively used in applications like computer-aided surgery, injury modeling, etc. While numerous constitutive models have been proposed in the literature, an objective method is needed to select a parsimonious model that represents the experimental data well and has good predictive capability. This is an important problem given the large variability in the data inherent to soft tissue mechanical testing.
In this work, we discuss a Bayesian approach to this problem based on Bayes factors. We propose a holistic framework for model selection, wherein we consider four different factors to reliably choose a parsimonious model from the candidate set of models. These are the qualitative fit of the model to the experimental data, evidence values, maximum likelihood values, and the landscape of the likelihood function. We consider three hyperelastic constitutive models that are widely used in soft tissue mechanics: Mooney-Rivlin, Ogden and exponential. Three sets of mechanical testing data from the literature for agarose hydrogel, bovine liver tissue, porcine brain tissue are used to calculate the model selection statistics. A nested sampling approach is used to evaluate the evidence integrals. In our results, we highlight the robustness of the proposed Bayesian approach to model selection compared to the likelihood ratio, and discuss the use of the four factors to draw a complete picture of the model selection problem.
This presentation focuses on data driven research from both a survey and in person interviews to articulate a roadmap for digital collection managers to navigate copyright challenges stemming from the adoption of standardized rights statements and licenses. Barriers to implementation of the RightsStatements.org statements and Creative Commons licenses will be described, including methods to remove such objections to using the standardized rights statements. Additionally, the research will outline the workflows of institutions that have been successful in the application of RightsStatements.org statements, what barriers they met, and the methods that were used to overcome the challenges they faced.
Dr. Deborah Duran is the director of NIMHD’s Office of Science Policy, Strategic Planning, Analysis, Reporting, and Data (OSPARD). She has 20 years of experience in organizational strategic planning, system assessments, science policy, measures, metrics, data management, performance monitoring, and reporting. Dr. Duran leads two branches within OSPARD: Science Planning, Policy, and Reporting; and Data, Assessments, Resources, and Evaluation. OSPARD serves NIMHD planning, assessment, analysis, and reporting needs and coordinates trans-NIH minority health and health disparities planning and reporting requirements. Dr. Duran hopes to help NIMHD become the centralized source of minority health and health disparities biomedical data, policies, and scientific advances.
Dr. Duran has spent much of her NIH career serving as performance director in the NIH Office of the Director, handling a wide range of responsibilities, including program performance monitoring, budget performance integration, organization performance assessments, and strategic planning. She designed a centralized online reporting system, currently used by NIH and the U.S. Department of Health and Human Services (HHS), to assist in the collection, analysis, and communication of organization performance information.
Dr. Duran trained in social psychology and virus research, statistics, evaluation, counseling, and computer science. She has experience as an educator, principal investigator, advocate, researcher, consultant, and counselor. Her areas of interest include system science, population health, Hispanic health, behavior research, cancer, coping, end-of-life care, palliative care, data systems, data management, and training minority youth.
Dr. Duran has a Ph.D. in social psychology with a minor in research methodologies and statistics. In 2000 and in 2004, Dr. Duran earned the HHS Secretary’s Award for Distinguished Service.
This was the morning keynote for the 4th Annual UC Data Day Conference hosted by UC Libraries.
The keynote presenter was Amanda J. Wilson, Head, National Network Coordinating Office, National Library of Medicine, All of Us Research Program partner
This talk was the first panelist in the Health Equities and Disparities Session for the 4th Annual UC Data Day Conference hosted by UC Libraries.
Reem Aly, JD, MHA, Health Policy Institute of Ohio
Talk Title: Closing Ohio’s health gaps: Moving towards equity
Reem Aly is the Vice President of Healthcare System and Innovation Policy at the Health Policy Institute of Ohio. Aly leads work on current and emerging health policy issues related to healthcare system and access, healthcare spending, social determinants of health and equity. She co-leads development of HPIO’s Health Value Dashboard and is currently leading HPIO’s contracted work to develop the state’s Maternal and Child Health and Maternal, Infant and Early Childhood Home Visiting Assessments.
Science teachers are often charged with providing discipline-specific literacy instruction. However, little is known about the reading and writing genres, or text types, typically found in these classrooms. In particular, there is a lack of knowledge about what opportunities adolescents have to engage with the genres privileged in science to learn the discipline's specialized ways of making meaning and communicating knowledge. This article reports on a case study of the reading and writing genres found within four middle-grade science classrooms in one small all-female school. Results suggest that although a variety of text genres were present, there was little discussion of how and why science content was presented in particular ways. Notably, students also had far more opportunities to read than write extended nonfiction. Teachers can cultivate a more reciprocal relation between reading and writing in science by using genres that students read as models for their writing.