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Filtrado por: Creador Grabowski, Gregory A. Departamento Cancer & Cell Biology

The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases

Type:

Article

Descripción/Resumen:

Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2. Results: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome. Conclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome. Significance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease).

Creador/Autor:

Grabowski, Gregory A.; Haffey, Wendy D.; Greis, Kenneth D., and Llou, Benjamin

Peticionario:

Kenneth Greis

Fecha modificada:

03/03/2017

Fecha modificada:

04/07/2017

Fecha de creacion:

2014-09

Licencia:

All rights reserved