The study of the propagation of multiple cracks is essential to modeling and predicting structural integrity. The interaction between two cracks depends on a number of factors such as the domain geometry, the relative crack sizes and the separation between the two crack tips. In this paper, we study the interaction between two dynamically propagating cracks. We use the phase field method to track the crack paths, since this method can handle complex crack behavior such as crack branching, without any ad hoc criteria for crack evolution. The results from our dynamic simulations indicate that, unlike crack inter- action under quasi-static or fatigue loading, the presence of another crack does not accelerate crack propagation when dynamic loads are applied. However, some similarities in the crack topologies are observed for both quasi-static and dynamic loading.
In the spring of 2001 the hilly uplands immediately northwest of the modern city of Durres were for the first time investigated using the techniques of intensive surface survey. In total, an area of six square kilometers was explored and twenty-nine sites were defined, most of them new. Remains of Greek antiquity were plentiful and include unpublished inscriptions and graves. One site may be the location of a previously unknown Archaic temple. Included in this article are descriptions of the areas investigated, a list of sites, and a catalogue of the most diagnostic artifacts recovered. Patterns of settlement and land use are discussed and compared to those recorded by other surveys in Albania.
The article begins with a question about the value of revitalising the equation between sexual/intimate violence and terrorism in the current neoliberal/post-feminist political and epistemological landscape. We argue that the intensifying international interest in sexual violence, and an accompanying hyper-visual imagery, is implicated in the cauterisation of critical thought about sexual violence. We offer the more mobile and expansive concept of sexed violence to “unthink” dominant narratives that reproduce heteronormativity and white, Western hegemony. Through an analysis of the film Unwatchable, we consider why non-white raced bodies consistently materialise as less “comprehensible” as violatable than white bodies. We further suggest that a move to sexed violence can help to think more critically about both sexual violence and feminism.
In urban middle schools, educators find it challenging to meet the literacy needs of the many struggling readers in their classrooms, including language-minority (LM) learners and students from low-income backgrounds. One strategy for improving these students' reading comprehension is to teach essential academic vocabulary in a meaningful, engaging, and systematic way. This article describes the development and evaluation of an academic vocabulary curriculum for sixth-grade mainstream classrooms with large numbers of LM learners who struggle with comprehension. In a study conducted in 21 sixth-grade classrooms, the curriculum was found to be effective both in improving students' vocabulary and reading comprehension and in supporting teachers' learning about how to teach academic vocabulary. Seven universal learnings for all classrooms are described and illustrated with specific examples of activities, perspectives from teachers, and insights from students, drawn from the study.
The present study aims to advance the extant research base by evaluating the implementation and effectiveness of an academic vocabulary program designed for use in mainstream middle school classrooms with high proportions of language minority learners. The quasi-experimental, mixed-methods study was conducted in 21 classes (13 treatment matched to 8 control) in seven middle schools in a large district, with 476 sixth-grade students (346 language minority learners, 130 native English speakers). Classroom observations and teacher logs indicated the 18-week program was implemented with good fidelity and that the approach contrasted sharply with the standard district English language arts (ELA) curriculum. Multilevel modeling indicated that the program resulted in significant effects on several aspects of vocabulary knowledge, including meanings of taught words (d = 0.39; p < .0001), morphological awareness (d = 0.20; p = .0003), and the word meanings as presented in expository text (d = 0.20; p = .0227). The program also yielded marginally significant, but promising effects on a depth of word knowledge measure (d = 0.15; p =0.0830) and a norm-referenced measure of reading comprehension (d = 0.15; p = .0568). No effects were found on a norm-referenced vocabulary measure. These effects were comparable for language minority learners and their native-English-speaking classmates. Data from teachers shed light on the challenges of meeting students' diverse instructional needs and the roles of curriculum and professional networks in building instructional capacity. The findings show promise in developing effective multifaceted vocabulary instruction for implementation by ELA teachers in middle school classrooms with high numbers of language minority learners.
The alternative education field lacks a common definition and has a major divide between the differing philosophies of alternative programs; little empirical evidence is available to identify the components necessary to create effective alternative educational programs. Tremendous growth in the availability of alternative programs in the United States over the past several decades, however, illustrates continuing demand for such programs as well as the need for research on the characteristics that constitute effective alternative programs. In this article, the authors study exemplary alternative programs in 3 racially and economically diverse communities to characterize the school climate as viewed by the students and the staff. At this relatively early stage in the field of alternative education, it is essential to examine the similarities, as well as any differences, in the social climate of highly effective alternative programs and to consider their potential relationship with student academic and behavioral success. Furthermore, it is important to recognize how these findings might be one foundation for future inquiry and research on alternative education. [PUBLICATION ABSTRACT]
Lloyd C. Engelbrecht (born 1927) is Professor Emeritus of Art History at the University of Cincinnati. His article, “Wood, Plywood and Veneer, Cranbrook, the New Bauhaus and the W. P. A.: the Origins of the Eames Chair of 1946,” had its origins in a paper presented at a symposium, “Bauhaus, New Bauhaus, W. P. A.: Chairs for Mid-Century,” October 17, 1981, at the Mid-America Conference of the College Art Association, meeting in Milwaukee. The article was expanded and eventually completed in 1987, but it was never published. The author asked that his late wife, June-Marie F. Engelbrecht (1930-2009), be given credit for her immense amount of help with the research and writing of the article.
Lloyd C. Engelbrecht (born 1927) is Professor Emeritus of Art History at the University of Cincinnati. This study guide was used to illustrate some of his classroom presentations and also on-site visits with his students to Prairie School buildings. This version of the study guide dates from May 10, 1994.
Each kml file in Google Earth is labeled according to a code based upon coin attributes (type of find, coin type, material, and date). This document explains the code used for coin finds that were minted at Antioch.
Lloyd C. Engelbrecht (born 1927) is Professor Emeritus of Art History at the University of Cincinnati. In collaboration with his late wife, June-Marie F. Engelbrecht (1930-2009), he has been researching, writing about and speaking about architect and designer Henry C. Trost (1860-1933) and his family firm of Trost & Trost.
On May 8, 2014, Lloyd Engelbrecht was invited to speak at the University of Texas at El Paso as part of a Trost symposium. The following is an excerpt from the official announcement of the symposium:
In celebration of Trost’s architectural legacy, UTEP Special Collections will host the “Trost Lecture Series” at 6 p.m. May 8  in the UTEP Library, Blumberg Auditorium, room 111.
The event will feature speakers Dr. Troy Ainsworth, executive director of El Camino Real de Tierra Adentro Trail Association (CARTA); Joe and Lanna Duncan, owners of the Trost-designed El Capitan Hotel in Van Horn, Texas and El Paisano Hotel in Marfa, Texas; and Dr. Lloyd Engelbrecht, co-author of Henry C. Trost: Architect of the Southwest.
A public exhibit featuring family photos, sketches, blueprints and photographs of the buildings Trost designed in El Paso and throughout the Southwest will be on display May 10 in the UTEP Library’s atrium on the third floor.
The lecture and exhibit were part of Trost Week, May 3-10, 2014, which was organized by the Texas Trost Society, a new nonprofit group that advocates for the preservation of Trost & Trost architecture.
Lloyd C. Engelbrecht (born 1927) is Professor Emeritus of Art History at the University of Cincinnati. He is author of Moholy-Nagy: Mentor to Modernism (Cincinnati: Flying Trapeze Press, 2009), two volumes. Moholy-Nagy: Mentor to Modernism is the first comprehensive, fully documented biography of the most fully-rounded creative figure of the twentieth century.
This introductory essay was originally published in German in 2014 in the Beiheft, or supplementary volume, that accompanies the first German edition of Vision in Motion.
László Moholy-Nagy, Sehen in Bewegung, Deutsche Fassung von László Moholy-Nagys vision in motion in der Übersetzung von Herwig Engelmann [on verso of title page: “Mit einem Beiheft mit Texten von Lloyd C. Engelbrecht, Hattula Moholy-Nagy und Philipp Oswalt”]
(Leipzig: Spector Books, 2014)
László Moholy-Nagy, Vision in Motion, “id BOOK, INSTITUTE OF DESIGN” (Chicago: Paul Theobald, 1947)
A sage expression, you make the road by walking, captures the nature of accompaniment in partnership development. The purpose of this action research project was to examine the partnership of a city school and an urban university as one that engaged mutual generation of knowledge from all participants. Action research, where participants are co-equals in decision-making, enhances the co-construction of knowledge and applied practice when stakeholders work to achieve more practical goals. Two high school co-instructors and a university faculty member examined what initially brought them together – a classroom instructional need. While designing and implementing an investigation of the use of class instructional time, they simultaneously conducted a self-study action research project about the dynamics of their partnership and how to improve it. Critical interviews revealed challenges to integrating research findings into practice as well as convergent benefits of partnership development that may be relevant to partnerships of all kinds.
Key Terms: Action research, collaboration, collaborative organizations, mode 2 knowledge creation, partnership development, research-practice gap
One proactive approach to increasing student engagement in schools is implementing Positive Behavior Intervention and Support (PBIS) strategies. PBIS focuses on prevention and concentrates on quality-of-life issues that include improved academic
achievement, enhanced social competence, and safe learning and teaching environments. This study is a replication of a study that investigated the combination of active supervision, precorrection, and explicit timing. The purpose of the study was to decrease student problem behavior, reduce transition time, and support maintenance of the intervention in the setting. Results show that active supervision, precorrection, and explicit timing decreased student problem behavior, decreased the duration of transitions in two instructional periods, and the intervention was maintained in the setting. Implications, limitations, and future research are discussed.
Keywords: active supervision, explicit timing, Positive Behavior Intervention and Support, precorrection, urban education
Lloyd C. Engelbrecht (born 1927) is Professor Emeritus of Art History at the University of Cincinnati. He is author of Moholy-Nagy: Mentor to Modernism (Cincinnati: Flying Trapeze Press, 2009). He will supply addenda and corrigenda for this book on a continuing basis.
The foreground Veil of material that lies in front of the Orion Nebula is the best studied sample of the interstellar medium because we know where it is located, how it is illuminated, and the balance of thermal and magnetic energy. In this work, we present high-resolution STIS observations toward the Trapezium, with the goal of better understanding the chemistry and geometry of the two primary Veil layers, along with ionized gas along the line of sight. The most complete characterization of the rotational/vibrational column densities of H2 in the almost purely atomic components of the Veil are presented, including updates to the Cloudy model for H2 formation on grain surfaces. The observed H2 is found to correlate almost exclusively with Component B. The observed H2, observations of CI, CI*, and CI**, and theoretical calculations using Cloudy allow us to place the tightest constraints yet on the distance, density, temperature, and other physical characteristics for each cloud component. We ﬁnd the H2 excitation spectrum observed in the Veil is incompatible with a recent study that argued that the Veil was quite close to the Trapezium. The nature of a layer of ionized gas lying between the Veil and the Trapezium is characterized through the emission and absorption lines it produces, which we ﬁnd to be the blueshifted component observed in S III and P III absorption. We deduce that, within the next 30–60 thousand years, the blueshifted ionized layer and Component B will merge, which will subsequently merge with Component A in the next one million years.
The purpose of this study was to define and examine the IASB’s
governance network. The IASB’s governance network was bound to include 14
organisational members and 407 individual actors. I used social network
methodology to examine the professional and geographic perspectives
represented as well as the extent to which the governance network was
structurally embedded. It was found that the network forms a definable
hierarchy that exhibits qualities of structural embeddedness. Banking interests
were more embedded within the governance network than any other
professional, academic, or social group. Also, a strong Western influence was
detected. The societal benefit of this effort was to engage society in general and
accounting researchers in particular in hopes of encouraging discourse about
regulatory processes with both macro and micro consequences.
Several constitutive theories have been proposed in the literature to model the viscoelastic response of soft tissue, including widely used rheological constitutive models. These models are characterized by certain parameters (“time constants”) that define the time scales over which the tissue relaxes. These parameters are primarily obtained from stress relaxation experiments using curve-fitting techniques. However, the question of how best to estimate these time constants remains open.
As a step towards answering this question, we develop an optimal experimental design approach based on ideas from information geometry, namely Fisher information and Kullback-Leibler divergence. Tissue is modeled as a standard linear solid and described using a one- or two-term Prony series. Treating the time constants as unknowns, we develop expressions for the Fisher information and Kullback-Leibler divergence that allow us to maximize information gain from experimental data. Based on the results of this study, we propose that the largest time constant estimated from a stress relaxation experiment for a linear viscoelastic material should be at most one-fifth of the total time of the experiment in order to maximize information gain.
Increasing interest is seen at the intersection of architecture and health. The built environment has become associated with a number of negative health outcomes including obesity, cancers, and diabetes. Engaging design students in these inquiries surrounding health is integral in preparing them for future practice. This paper reviews the conceptual development and tested implementation of an interdisciplinary course focusing on the wellbeing and overall health of the occupant, using primary and secondary framework structures in the vein of Groat and Wang’s logical argumentation. The reviewed course engages interdisciplinary teams composed of students from the School of Architecture, the College of Engineering, and the College of Natural Resources, with private practice. The course puts forth an effort to break out of the conventional pedagogical structure found in architectural education, primarily the studio and large lecture spaces. The course has been specifically designed to: (1) establish a framework for common content relating to health in the built environment across disciplinary boundaries; (2) build meaningful partnerships between interdisciplinary student groups; and (3) establish a common vocabulary between architectural education and aligned disciplines regarding health and the built environment. The course structure, activities, and assessments are reviewed, proposing a solid framework for including integrated design and themes of health in architectural education.
A Process Guide for Establishing State Adult Education Content Standards was developed by the American Institutes for Research as part of the Adult Education Content Standards Warehouse Project under contract to the U.S. Department of Education, Office of Vocational and Adult Education, Contract No. ED-01-CO-0026/0023.
IASDR 2017 Guest Speaker
Meredith Davis has taught for forty-seven years and served as head of the Department of Graphic Design, Director of Graduate Programs in Graphic Design, and Director of the PhD Design program at NC State University. She is an AIGA fellow and national medalist, Alexander Quarles Holladay Medalist for Teaching Excellence, and fellow and former member of the accreditation commission of the National Association of Schools of Art and Design, for which she drafted the national standards for the evaluation of college-level design programs. She serves as a member of the education advisory committee of the Cooper Hewitt Smithsonian National Design Museum and is a former president of the American Center for Design. Meredith is a frequent author–including four books on design and design education– and serves on the editorial boards of She Ji and Design Issues. Her research includes a two-year study of design-based teaching and learning for the National Endowment for the Arts, which received a CHOICE award from the National Association of College and Research Libraries.
She has served on the development teams for two National Assessments of Educational Progress, most recently for the scenario-based evaluation of 21,500 students in Technology and Engineering Design Literacy. She authored a five-year research study of teaching critical and creative thinking across the college curriculum, featured in a study by the Organization for Economic Co-operation and Development on the effectiveness of higher education in preparing students for innovation jobs. She has reviewed proposals for the Smithsonian Office of Education and Museum Studies, National Science Foundation, US Department of Education, Institute of Museum and Library Services, and Canadian Foundation for Innovation, and her work has been funded by the Kenan Institute for Engineering, Science and Technology; National Endowment for the Arts; Worldesign Foundation; and several state commissions.
Kaleidoscope-Special Sessions Presentation
You may have labored for years to achieve your current market success. But as your success grows, so do expectations.
Growth targets require both capitalizing on existing business practices and innovating new ones. It can be a challenge to do both.
Kaleidoscope's VP of Research and Development, Mike Clem, DVM, Ms shares his understandable, memorable and easy-to- apply "Ships and Castle" model.
In societies where productivity is prioritized over presence, anxiety abounds. The extensive and alarming effects of anxiety on the mental and physiological wellbeing of bachelor students inspired a cross-disciplinary team to tackle this problem. Using combined expertise in visual design, music technology, psychology, art therapy and mindfulness — a digital tool entitled “Modes” was born. The Modes digital tool is an atmospheric, introspective, and aesthetically sophisticated engagement of three senses: ophthalmoception (sight), audioception (hearing), and tactioception (touch). Through immersive interaction, mesmerizing visual and sound landscapes are generated in order to reduce anxiety in bachelor students. The two measurable outcomes of Modes are 1) the reduction of self-reported anxiety in bachelor students, and 2) the reduction of bachelor student heart rates.
Interacting with the Modes digital tool is like playing in a sandbox of dynamic visuals and music. Users begin by selecting and entering one of three digital environments entitled Refocus, Chill, or Energize. Each environment (or mode) offers a unique set of visuals and music designed specifically for anxiety reduction. The design and functionality of Modes are rooted in tenets of mindfulness practice and Ayurveda — an ancient Indian healing system emphasizing inner balance as a method for maintaining health and wellness (Kiefer, 2016). The Refocus, Chill, and Energize modes aim to balance each of three governing principle of Ayurveda that regulate physiological activity. Ultimately, users may combat and control their anxiety in three targeted ways: by refocusing, chilling, or energizing.
IASDR 2017 Guest Speaker
Tracy Moss is an independent design consultant and currently serves as the Course Director for Counter-Proliferation Opportunity Design at Joint Special Operations University, MacDill Air Force Base, Florida. As co-founder of the U.S. Special Operations Command (USSOCOM) Design Thinking education program, she also serves as core faculty for the full complement of design-related courses and activities at the university and headquarters.
Ms. Moss retired from military service in 2015 having spent 20 years on active duty in both the U.S. Air Force and U.S. Navy. During her final four years of military service at USSOCOM, she served as the lead Analyst and Planner on two operational design teams and as Chief of Counter-Weapons of Mass Destruction Analysis.
This presentation suggests a new transversal image of thought to grasp the creation of an ethical series of events in which architectural history/theory coursework engages in multi-educational rhizomatic ‘plateaus’. It does so by combining the philosophies and notions of impersonality and effects of French post-structuralist Gilles Deleuze, with that of Simone Brott (an Australian architect), as the basis for a cartographic analysis of the empirical subjectivity that works as a set of impersonal effects to reformulate the architectural history/theory coursework.
IASDR 2017 Guest Speaker
Bob Schwartz joined GE Healthcare (GEHC) in December 2007 as General Manager, Global Design & User Experience. With five studios in four countries, Bob is responsible for overseeing the Global Design function encompassing human factors, industrial design, ergonomics, user-interface, environmental design, and design research. As a strategic driver of organic business growth, his team focuses on the look, feel usability and end-to-end experience of GEHC products and services. Bob is also the GE Healthcare Global Executive Sponsor of the People with Disabilities Network.
Since 2009, Global Design/UX has been the recipient of 19 medals from the International Design Excellence Awards (IDEA) and was listed, in 2011, by Fast Company magazine as a Corporate Design Stronghold. In 2015, Bob’s career trajectory was cited by Fast Company as among the top Chief Design Officers. In 2015 the Industrial Designers Society of America (IDSA) named him among the 50 most notable industrial designers of the last 50 years. Bob was recently elected Chair of the Board of the Design Management Institute.
Continuously engaged in Design education throughout his career, he is a two-term member of the Board of Trustees of the Milwaukee Institute of Art & Design and its Executive Committee and is Chair of its Academic Excellence Committee.
Bob is also a member of the Design Management Advisory Board at Northwestern University and has had similar roles at Savannah College of Art and Design and Carnegie Mellon University. Further, he has also held a design faculty appointment at the University of Cincinnati. While at P&G, Bob applied his leadership to developing the School Collaboratives Program there and has created similar relationships in his other roles with academic institutions globally.
Bob joined GEHC from Procter & Gamble, where he was a global design leader working to transform the design function there to a strategically relevant capability, which is now comprised of 350 global designers and design managers. Prior to P&G, Bob was Vice President, New Product Development, at Levolor Kirsch, a division of Newell Rubbermaid, where he brought innovation to the home decor industry. At Motorola, Bob was the Director of Design, responsible globally for all key product lines within the Commercial, Government, Industrial and Consumer Products businesses.
As Executive Director and COO for the Industrial Designers Society of America (IDSA) Bob forged an unprecedented relationship with Business Week magazine to annually publish the Industrial Design Excellence (IDEA) awards and later the Catalyst Awards. This accomplishment led to Bob receiving a United Nations appointment to the People's Republic of China as Senior Advisor for Design. He has also testified before Congress on a Bill to establish a US Design Center in the Dept. of Commerce.
Bob was also the Director, Science and Technology Programs for AdvaMed, where he forged strong partnerships with the FDA, HCFA and Congress and lobbied and directed policy and voluntary standards research for circulatory and cardiovascular devices, healthcare information systems and the prevention of sexually transmitted diseases. Prior to this, Bob was the head of Corporate Industrial Design and Architecture for the American Red Cross, where he implemented new nation-wide mobile blood collection, tissue banking and disaster services systems and blood center laboratory designs.
Most notably, Bob was inducted into the IDSA Academy of Fellows at the 2007 World Congress of Industrial Design, for his outstanding contributions to the industry.
Bob has a Masters degree in Industrial Design from the Rhode Island School of Design, where he was a Roddy Scholar, and a Bachelor of Fine Arts in Industrial & Graphic Design from the Kansas City Art Institute.
IASDR 2017 Workshop
Design now faces with new challenges that have made us rethink about our current design paradigm. It motivated us to organize a forum called, Design 3.0 Forum at KAIST in 2016, where we invited globally renowned design researchers and practitioners from different countries to discuss about important agenda for emerging challenges. The agenda we extracted from this forum can be summarized as follows: 1) envisioning of designers' future roles on open creativity and design; 2) dissemination and evaluation of design research outcomes by keeping deep design values; and 3) post education and practice that moves beyond the current use-centered perspectives by thinking big toward social innovation and large-scale impact.
As the result of the Design 3.0 forum, we all agreed that we must continue to develop and extend these agenda and collaboratively make executable actions to carry them out in the design community. In this special session at IASDR 2017, not only the organizers of the previous Design 3.0 forum (i.e. Youn-kyung Lim, Ron Wakkary, Kun-pyo Lee, and Tek-jin Nam), we invite the people who have not participated in the previous forum but can provide important insights on these issues. For the format of the session, we will take the panel format where the invited participants will present their positions first, and then have in-depth discussion on them among the participants and the audience. Through this special session, we expect to advance the initial Design 3.0 agenda and can generate more concrete and executable action items for Design 3.0.
Please follow developments of this work at http://design3-0.org/2017iasdr/
IASDR 2017 Guest Speaker
Mark Hallerberg is Dean and Professor of Public Management and Political Economy at the Hertie School of Governance, a private public policy School in Berlin, Germany. His research focuses on fiscal governance, tax competition, financial crises, public sector innovation, and European Union politics.
He previously held academic positions at Emory University, where he maintains an affiliation with the political science department, as well as at the University of Pittsburgh and Georgia Institute of Technology. He received his PhD from UCLA in 1995.
*Use Related Links URL to access presentation video
Seattle Cancer Care Alliance and Premera Blue Cross show you how we conducted design research to build a collective understanding of the cancer care experience. We will provide detailed instructions, with checklists, on how to recreate a similar collaboration, including how we worked and what we worked on. You will walk away knowing how we shared skills and resources, built credibility and equal playing fields, and delivered research insights to both our organizations from multiple perspectives and vantage points.
Seattle Cancer Care Alliance (SCCA) brings together the leading research teams and cancer specialists from Fred Hutchinson Cancer Research Center, Seattle Children's and UW Medicine. Based in Seattle, SCCA is one of the top five Adult Cancer Care facilities in the United States as ranked by U.S. News & World Report. Shay Ghassemian, User Experience Designer in Digital Health, and Katie Rehfield, Patient Experience Specialist, will be facilitating this workshop.
Premera Blue Cross is a not-for-profit health insurance company serving 2 million people across the United States. As the largest health plan in the Pacific Northwest, Premera offers a wide range of products for individuals and families, Medicare recipients, and employers ranging from small business to Fortune 100 companies. Irish Malig, Senior Manager of Experience Strategy, Robert Racadio, Design Research Manager, Design Strategists Sara Bell, Paul Braun, and Ryan Rosensweig, and Darci Brown, Healthcare Implementation Manager in Provider Experience, will all be facilitating this workshop.
Presented by Shay Ghassemian and Robert Racadio
This paper expounds the background of Chinese design education as well as the orientation of the design education of Tongji University in the new times, it also collects 458 master thesis of College of Design and Innovation during 2010-2016 as analyzed sample. Based on the coding of subject classification, quantitative analysis and content analysis are made in order to understand the interdisciplinary education status of College of Design and Innovation from the two perspectives: the overall cross-disciplinary performance and the relationship between different cross-disciplinary directions.
Science teachers are often charged with providing discipline-specific literacy instruction. However, little is known about the reading and writing genres, or text types, typically found in these classrooms. In particular, there is a lack of knowledge about what opportunities adolescents have to engage with the genres privileged in science to learn the discipline's specialized ways of making meaning and communicating knowledge. This article reports on a case study of the reading and writing genres found within four middle-grade science classrooms in one small all-female school. Results suggest that although a variety of text genres were present, there was little discussion of how and why science content was presented in particular ways. Notably, students also had far more opportunities to read than write extended nonfiction. Teachers can cultivate a more reciprocal relation between reading and writing in science by using genres that students read as models for their writing.
Overnight, room temperature hold
(ONH) of whole blood before component processing
offers several benefits. This study evaluated the storage
and in vivo recovery characteristics of ONH red blood
cells (RBCs) stored in additive solution-7 (AS-7).
Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates
Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased
insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.
Stat3-mediated modification plays a role in early tumorigenesis.
PM-18. EGFR-STAT3 ACTIVATES b-CATENIN SIGNALING TO
DRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A
ROLE IN TUMOR MAINTENANCE
Nancy Ratner1, Vincent Keng2, Deanna M. Patmore1, Jed K. Kendall1,
Edwin Jousma1, Kwangmin Choi1, Danhua Fan2, Eric B. Schwartz2, James
R. Fuchs2, Yuanshu Zou2, Mi-Ok Kim1, Eva Dombi5, David E. Levy6, Jose
A. Cancelas1, Anat Stemmer-Rachamimov4, Robert J. Spinner3, and David
Cincinnati Children’s, Cincinnati, OH, USA; 2
Minnesota, Minneapolis, MN, USA; 3
Mayo Clinic, Rochester, MN, USA; 4
Massachusetts General Hospital, Boston, MA, USA; 5
Institute Pediatric Branch, Bethesda, MD, USA; 6
New York University School
of Medicine, New York, NY, USA
To identify genes and signaling pathways that drive peripheral nerve tumor
initiationand growth beyond the Ras-MAPK pathwaywe used unbiased insertional
mutagenesis screening. We identified Stat3 as a potential driver of
Neurofibromatosis type 1 neurofibroma. Targeted genetic deletion of Stat3
in Schwann cell precursors (SCPs) and Schwann cells (SCs) largely prevented
neurofibroma formation, and self-renewal of tumor initiating cells. Genetic
gain- and loss-of-function identified EGFR as the major upstream regulator
of P-Stat3 in mouse and human neurofibroma SCP and in neurofibroma initiation;
IL-6 reinforced EGFR/Jak/Stat signaling. Preclinical tests of a Jak2/
Stat3 inhibitor reduced established neurofibroma growth, supporting an additional
role for Stat3 in benign nerve tumor maintenance. Unexpectedly, downstream
of Stat3, we identified b-catenin, and b-catenin expression rescued
phenotypic effects of Stat3 loss in SCPs. Phosphorylated STAT3 (Y705) and
b-catenin were strongly correlated in NF1 human plexiform neurofibromas.
The data support testing of JAK/STAT inhibition and Wnt/ b-catenin
pathway inhibition in neurofibroma therapeutic trials. Supported by: NIH
R01 NS28840 to N.R. and NIH P50 NS057531 to N.R. and D.L.), a
DAMD New Investigator Award (W81XWH-11-1-0259) and an Ohio State
University Comprehensive Cancer Center Pelotonia Idea Grant (to J.W.).
The American Cancer Society (IRG-67-003-44) supported J.R.F.
Severe congenital neutropenia (SCN) is often associated with inherited heterozygous point mutations in ELANE, which
encodes neutrophil elastase (NE). However, a lack of appropriate models to recapitulate SCN has substantially hampered
the understanding of the genetic etiology and pathobiology of this disease. To this end, we generated both normal and SCN
patient–derived induced pluripotent stem cells (iPSCs), and performed genome editing and differentiation protocols that
recapitulate the major features of granulopoiesis. Pathogenesis of ELANE point mutations was the result of promyelocyte
death and differentiation arrest, and was associated with NE mislocalization and activation of the unfolded protein
response/ER stress (UPR/ER stress). Similarly, high-dose G-CSF (or downstream signaling through AKT/BCL2) rescues
the dysgranulopoietic defect in SCN patient–derived iPSCs through C/EBPβ-dependent emergency granulopoiesis. In
contrast, sivelestat, an NE-specific small-molecule inhibitor, corrected dysgranulopoiesis by restoring normal intracellular
NE localization in primary granules; ameliorating UPR/ER stress; increasing expression of CEBPA, but not CEBPB; and
promoting promyelocyte survival and differentiation. Together, these data suggest that SCN disease pathogenesis includes
NE mislocalization, which in turn triggers dysfunctional survival signaling and UPR/ER stress. This paradigm has the
potential to be clinically exploited to achieve therapeutic responses using lower doses of G-CSF combined with targeting to
correct NE mislocalization.
Patients in organ failure of vascular origin have increased circulating hematopoietic stem cells and
progenitors (HSC/P). Plasma levels of angiotensin II (Ang-II), are commonly increased in
vasculopathies. Hyperangiotensinemia results in activation of a very distinct Ang-II receptor set,
Rho-family GTPase members, and actin in bone marrow endothelial cells (BMEC) and HSC/P,
which results in decreased membrane integrin activation in both BMEC and HSC/P, and in HSC/P
de-adhesion and mobilization. The Ang-II effect can be reversed pharmacologically and
genetically by inhibiting Ang-II production or signaling through BMEC AT2R, HSCP AT1R/
AT2R or HSC/P RhoA, but not by interfering with other vascular tone mediators.
Hyperangiotensinemia and high counts of circulating HSC/P seen in sickle cell disease (SCD) as a
result of vascular damage, is significantly decreased by Ang-II inhibitors. Our data define for the
first time the role of Ang-II HSC/P traffic regulation and redefine the hematopoietic consequences
of anti-angiotensin therapy in SCD.
Chromosome 5q deletions (del[5q]) are common in
high-risk (HR) myelodysplastic syndrome (MDS) and
acute myeloid leukemia (AML); however, the gene
regulatory networks that sustain these aggressive
diseases are unknown. Reduced miR-146a expression
in del(5q) HR MDS/AML and miR-146a/ hematopoietic
stem/progenitor cells (HSPCs) results in
TRAF6/NF-kB activation. Increased survival and proliferation
of HSPCs from miR-146alow HR MDS/AML is
sustained by a neighboring haploid gene, SQSTM1
(p62), expressed from the intact 5q allele. Overexpression
of p62 from the intact allele occurs through
NF-kB-dependent feedforward signaling mediated
by miR-146a deficiency. p62 is necessary for
TRAF6-mediated NF-kB signaling, as disrupting the
p62-TRAF6 signaling complex results in cell-cycle arrest
and apoptosis of MDS/AML cells. Thus, del(5q)
HR MDS/AML employs an intrachromosomal gene
network involving loss of miR-146a and haploid overexpression
of p62 via NF-kB to sustain TRAF6/NF-kB
signaling for cell survival and proliferation. Interfering
with the p62-TRAF6 signaling complex represents a
therapeutic option in miR-146a-deficient and aggressive
Low-dimensional models have proven essential for feedback control and estimation of flow fields. While feedback control based on global flow estimation can be very efficient, it is often difficult to estimate the flow state if structures of very different length scales are present in the flow. The conventional snapshot-based proper orthogonal decomposition (POD), a popular method for low-order modeling, does not separate the structures according to size, since it optimizes modes based on energy. Two methods are developed in this study to separate the structures in the flow based on size. One of them is Hybrid Filtered POD method and the second one is 3D FFT-based Filtered POD approach performed using a fast Fourier transform (FFT)-based spatial filtering. In both the methods, a spatial low-pass filter is employed to precondition snapshot sets before deriving POD modes. Three-dimensional flow data from the simulation of turbulent flow over a circular cylinder wake at Re=20000 is used to evaluate the performance of the two methods. Results show that both the FFT-based 3D Filtered POD and Hybrid Filtered POD are able to capture the large-scale features of the flow, such as the von Karman vortex street, while not being contaminated by small-scale turbulent structures present in the flow.
The present investigation deals with the application of an Adaptive Fuzzy Control Algorithm for active vibration control of an experimental flexible beam. The two-dimensional model of the experimental cantilever beam, given by an orthogonal tetrahedral space truss, represents a slender cantilever aluminum (7075-T6) beam of rectangular cross-section (1145 × 60 × 1.95 mm3). A variety of transient disturbances are introduced to excite the first four modes of the beam. The resulting transverse displacements are observed by a single sheet (50 × 50 mm2) of piezoceramic material placed at the clamped end of the beam. Active control of the beam is provided by one, two or three identical sheets of piezoceramic material collocated with the sensor. The control moments applied by the piezoceramic actuator are made to emulate the behavior of a discrete dynamic vibration absorber. The virtual absorber is tuned to the fundamental frequency using classical methods and the tuning ratios are time-invariant. However, the uniqueness of this approach is that the damping parameters of the emulated absorber are continuously varied by means of a fuzzy logic control algorithm to provide near minimum-time suppression of vibration. It is demonstrated that application of this methodology allows for its real-time implementation and provides relatively quick settling times in the closed-loop.
A general methodology has been developed for the design of a robust control law for a family of lightly damped second order problems. In this research effort, the passivity approach has been extended to systems having non-collocated input/output pairs by introducing an observer that incorporates the nominal dynamical model of the plant. The developed passive observer-based control law emulates numerous dynamic vibration absorbers which are tuned to a targeted frequency using classical methods and the tuning ratios are time-invariant. However, the uniqueness of this approach is that the damping parameters of the emulated absorbers are continuously varied by means of a fuzzy logic control algorithm to provide near minimum-time suppression of vibration. The developed approach is applied to both several benchmarks in the field of structural dynamics as well as experiments using piezo-ceramic sensors and actuators. Results show that this methodology provides stability and performance robustness on the one hand as well as requiring relatively low amount of actuation authority for desired nominal plant closeloop behavior.