The Retrosplenial Cortex (RSC) has a persistent role in the establishment of spatial and contextual memory, with also the connections between visuo-spatial association cortices. The RSC’s ability to form afferent and efferent connections with the Parahippocampal areas of the brain allow it to be another prime location in the brains of both rodents and humans where multiple cues are linked together in memory formation, storage and retrieval of Long Term Memories. Due to the high nature of memory formation and retrieval, the RSC has become a section of the brain that in recent years has been more heavily focused on for the research of Alzheimer’s and Dementia. The RSC has not been examined fully in previous studies with examination of the expression of the apolipoprotein E (APOE) gene along with other genetic and regulatory factors. There are 3 major alleles of the APOE gene (APOE2, APOE3, and APOE4), with APOE4 having the greatest risk for AD. In this research, I identify the relative connection between DEK the proto-oncogene and APOE3 and APOE4 in a rodent model, looking specifically at the RSC and how it affects spatial memory with an induced model of chronic stress.
Incipit: Anberpvlbabioni lingua e segni dell alchemia
Holograph manuscript, 37 lines to the page
Sewn in center of sheet, unbound
Watermark: small left facing bird
Contains alchemical recipes and instructions for making the philosopher's stone
Contains, beginning at leaf 15: Libro 2° di bellismi secret dell'arte chimica Piebra filosofica
List of chemical symbols used in text given on first page
Contains two designs for Athanors (chemical vessals) in text
Published: Northern Italy?, mid 17th century?
1 v. (100 p., numbered as 50 leaves) : ill. ; 29 cm (fol.) + in slipcase with slide-out portfolio ; 31 cm