Proceedings of the 1993 Conference on Communication and Environment (COCE), Big Sky MT. Editors: James G. Cantrill and M. Jimmie Killingsworth. Individual authors retain all publication rights.
The present study examined acoustic, aerodynamic, and videostroboscopic measures of voice production following BOTOX injections in 4 patients with Adductor Spasmodic Dysphonia. Videostroboscopic measures showed a return to some normal aspects of vocal fold vibration 1 month post-injection. Several subjects exhibited suggested meaningful differences both one week and one month post-injection for acoustic and aerodynamic measures; however, results were highly variable and often did not bring the subjects' values into the normal range.
Compared to other drugs of abuse, studies of the effects of nicotine on intracranial self-stimulation (ICSS) are few in number. Since the effect of nicotine on reward is not well established, one goal of the present study was to clarify the characteristics of nicotine-induced changes in brain stimulation reward using a rigorously validated, rate-free and reward-selective procedure. Once established, the second goal was to assess the ability of specific dopamine (sulpiride), serotonin (MDL 26,508), and mixed dopamine/serotonin (MDL 28,133A) antagonists to modify nicotine's effects.