Background: Role of apolipoprotein (apo) A-II on metabolism of high density lipoproteins (HDLs) is unknown.
Results: Conformational changes of apoA-I, the major apolipoprotein of HDL, caused by apoA-II in discoidal HDL are confined to two regions of apoA-I.
Conclusion: Interactions between the two major apolipoproteins in discoidal HDL are site specific.
Significance: Functional implications of HDL complexes will significantly benefit from such structural information.
Shortly after the comparative analysis of Codding et al. was published, I prepared a comment on the article that I submitted for publication. In response to feedback from the editors, I eventually revised the manuscript substantially. That revised version has now been published. In this paper, I share the original submission of the comment, which focuses on important considerations for future studies of risk-‐ sensitive foraging. Meanwhile, Codding and his colleagues have published a response to my comment. They exhibit some confusion about my position, which they describe as “paradoxical.” In a reply to their response, I have therefore added some clarifying remarks at the end of this paper