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  • Promotion of food allergy by the unfolded protein response (preprint)

    Document thumbnail: Promotion of food allergy by the unfolded protein response (preprint)
    Type:
    Document
    Description/Abstract:
    This is a preprint of a to be submitted paper that demonstrates that: (1) many important food allergens (eggs, milk, peanuts, tree nuts) induce the unfolded protein response (UPR) in intestinal epithelial cells; (2) induction of the UPR, in turn, stimulates the expression of pro-Th2 cytokines (IL-25, IL-33, TSLP) that are required for the induction of food allergy by these cytokines; (3) egg allergy is suppressed in mouse models by the UPR inhibitor, metformin (a drug widely used to treat diabetes mellitus); and (4) metformin appears to have a protective effects in humans who have alpha-gal syndrome, which is a form of food allergy.
    Creator/Author:
    Finkelman, Fred
    Submitter:
    Fred Finkelman
    Date Uploaded:
    06/02/2020
    Date Modified:
    06/02/2020
    Date Created:
    2020-06-02
    License:
    Open Data Commons Attribution License (ODC-By)