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  • Non-muscle myosin II 2026

    User Collection
    Collection thumbnail: Non-muscle myosin II 2026
    Type:
    Collection
    Description/Abstract:
    Background: Non-muscle myosin IIA (NMIIA; encoded by MYH9) has been implicated in breast cancer progression; however, its clinical significance and therapeutic potential in HER2-positive (HER2+) breast cancer remain poorly defined. We investigated the clinical significance of NMIIA and evaluated the anti-tumour activity of the selective NMII inhibitor MT-228. Methods: NMIIA expression was evaluated by immunohistochemistry in a cohort of 1,142 patients with early-stage invasive breast cancer. Molecular docking and molecular dynamics simulations were performed to characterize binding of MT-228 to NMIIA. The effects of MT-228 were assessed in breast cancer cell lines using assays of cell viability, migration, three-dimensional invasion, DNA damage, apoptosis, and combination studies with FDA approved HER kinase inhibitors Neratinib and Tucatinib. Results: High NMIIA expression was associated with adverse clinical outcomes in patients with HER2 immunoreactive breast cancer. Computational analyses demonstrated that MT-228 forms favorable binding interactions and stabilized the NMIIA motor domain. MT-228 inhibited cell growth across multiple breast cancer subtypes. In HER2+ cell lines, MT-228 suppressed migration and 3D invasion, increased γH2AX foci formation, caspase-3/7 enzyme activity, and PARP cleavage, and enhanced the anti-proliferative activity of Neratinib and Tucatinib. Conclusions: Our findings identify NMII as a potential therapeutic target in HER2 immunoreactive breast cancer and support further investigation of selective NMII inhibition either alone or in combination with anti-HER therapies.
    Creator/Author:
    Feroz, Wasim and Garrett, Joan
    Submitter:
    Joan Garrett
    License:
    Attribution 4.0 International
    0Collections
    0Works

  • REALIZE REU

    User Collection
    Collection thumbnail: REALIZE REU
    Type:
    Collection
    Description/Abstract:
    Podcasts produced by students participating in the REALIZE REU at University of Cincinnati. This collection is still growing and is a work in progress.
    Creator/Author:
    Payton, Eric
    Submitter:
    Eric Payton
    License:
    Attribution-NonCommercial 4.0 International
    0Collections
    5Works

  • HSC and Metabolism

    User Collection
    Collection thumbnail: HSC and Metabolism
    Type:
    Collection
    Description/Abstract:
    Cell Stem Cell Volume 33, Issue 2p289-305.e6February 05, 2026
    Creator/Author:
    Filippi, Marie-Dominique
    Submitter:
    Marie-Dominique Filippi
    License:
    Public Domain Mark 1.0
    0Collections
    0Works

  • R01 NIGMS 2025_2029

    User Collection
    Collection thumbnail: R01 NIGMS 2025_2029
    Type:
    Collection
    Description/Abstract:
    This collection is for works and publications related to NIGMS R01 (2025_2029).
    Creator/Author:
    Hong, Christian
    Submitter:
    Christian Hong
    License:
    All rights reserved
    0Collections
    0Works

  • Materials Science, Art Materials, Archaeometry, and Ceramics

    User Collection
    Collection thumbnail: Materials Science, Art Materials, Archaeometry, and Ceramics
    Type:
    Collection
    Description/Abstract:
    The documents in this collection relate to writings on the subject of archaeometry, technical ceramics, artists materials, and historical research. Techniques such as X-ray Diffraction, X-Ray Fluorescence, Spectroscopy, wet chemical analysis are used to analyze historical and contemporary materials.
    Creator/Author:
    Carr-Trebelhorn, Julia
    Submitter:
    Julia Carr-Trebelhorn
    License:
    Attribution-NonCommercial-NoDerivs 4.0 International
    0Collections
    1Works

  • BA in Art History Capstone Project

    User Collection
    Collection thumbnail: BA in Art History Capstone Project
    Type:
    Collection
    Description/Abstract:
    The Dual Representation of Apsaras in Indian Culture
    Creator/Author:
    Gargi Bhalerao
    Submitter:
    Gargi Bhalerao
    License:
    CC0 1.0 Universal
    0Collections
    0Works

  • 2026 Information Technology Research Symposium

    User Collection
    Collection thumbnail: 2026 Information Technology Research Symposium
    Type:
    Collection
    Description/Abstract:
    The School of Information Technology (SoIT) at the University of Cincinnati hosts the Information Technology Research Symposium on an annual basis as a forum for the exchange and dissemination of research ideas through the IT EXPO. The 2026 symposium was held on April 13-14, 2026 and this collection features the digital proceedings of presentations. The primary purpose of the symposium is to exchange research ideas among graduate students, faculty, industry, and practitioners involved in IT research in our field. IT research topics range from state-of-the-art system development to recent progress in scientific endeavors that are theoretical or applied areas of Information Technology, such as cybersecurity, data analytics, Internet of Things (IoT), IT infrastructure, interactive gaming, technologies for smart and connected cities, and user-centered design among others.
    Creator/Author:
    Kropczynski, Jess
    Submitter:
    Jess Kropczynski
    License:
    All rights reserved
    0Collections
    0Works

  • G-LiHT Yucatan Peninsula - 100cm / pixel DEM GeoTIFF files

    User Collection
    Collection thumbnail: G-LiHT Yucatan Peninsula - 100cm / pixel DEM GeoTIFF files
    Type:
    Collection
    Description/Abstract:
    G-LiHT Yucatan Peninsula - 100cm / pixel DEM GeoTIFF files
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    0Works

  • G-LiHT Yucatan Peninsula - 33cm / pixel DEM GeoTIFF files

    User Collection
    Collection thumbnail: G-LiHT Yucatan Peninsula - 33cm / pixel DEM GeoTIFF files
    Type:
    Collection
    Description/Abstract:
    G-LiHT Yucatan Peninsula - 33cm / pixel DEM GeoTIFF files Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S). Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download. To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    13Works

  • G-LiHT Yucatan Peninsula - G1 layered visualization GeoTIFF files

    User Collection
    Collection thumbnail: G-LiHT Yucatan Peninsula - G1 layered visualization GeoTIFF files
    Type:
    Collection
    Description/Abstract:
    G-LiHT Yucatan Peninsula - G1 layered visualization GeoTIFF files Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S). Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download. To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    13Works

  • G-LiHT Yucatan Peninsula - 50cm / pixel DEM GeoTIFF files

    User Collection
    Collection thumbnail: G-LiHT Yucatan Peninsula - 50cm / pixel DEM GeoTIFF files
    Type:
    Collection
    Description/Abstract:
    G-LiHT Yucatan Peninsula - 50cm / pixel DEM GeoTIFF files Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S). Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download. To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    13Works

  • G-LiHT Yucatan Peninsula Ground-filtered LAZ files

    User Collection
    Collection thumbnail: G-LiHT Yucatan Peninsula Ground-filtered LAZ files
    Type:
    Collection
    Description/Abstract:
    G-LiHT Yucatan Peninsula Ground-filtered LAZ files Scroll down on this page to select a Region (South, North2, Centro, Norte, Out, Chiapas, Campeche) and a Flight (NFI = E/W, GLAS = N/S). Click on the Region/Flight you want, then scroll down the next page to find the transect you intend to download. To download the transect for inspection and use, scroll right, and in "Select an Action", choose Download and the file will download to your local drive. Some of the files are large, so leave sufficient time and check to ensure it is fully downloaded before attempting to open or copy it.
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    13Works

  • G1 G-LiHT Lidar Reprocessing for Maya Archaeology

    User Collection
    Collection thumbnail: G1 G-LiHT Lidar Reprocessing for Maya Archaeology
    Type:
    Collection
    Description/Abstract:
    This is a collection created in 2026 from the original G-LiHT LAS files from the Goddard Ames website where the G-LiHT data has its home archive;  https://gliht.gsfc.nasa.go Seven Regions are included in the form of a series of files for each transect. The ground-flitered LAZ file; 50cm/px DEM GeoTIFF; 33cm GeoTIFF; 100cm GeoTIFF; G1 layered visualizations Out-of-Yuc (Out), Yuc_Centro (Centro) Yuc_North2 (North2) Yuc_Norte (Norte) Yuc-South (South) Yuc_Chiaps (Chaips) Yuc_Chiapas_Campeche (Campeche) Click on any of the five subcollections below to browse and select in the collection. Select your choice of the five: 33cm/px TIF visualizations, 33cm/px DEM GeoTIFFs, 50cm/px DEM GeoTIFFs, 100cm/px DEM GeoTIFFs, or ground-filtered LAZ files
    Creator/Author:
    Britton, Benjamin
    Submitter:
    Benjamin Britton
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    5Collections
    0Works

  • Alexandre Brongniart: the Invention of Ceramic Science and Coining the Word "Ceramic"

    User Collection
    Collection thumbnail: Alexandre Brongniart: the Invention of Ceramic Science and Coining the Word "Ceramic"
    Type:
    Collection
    Description/Abstract:
    The two papers of this collection discuss the formalization and naming of ceramic science as well as on the practice of ceramics in the late nineteenth and twentieth centuries.
    Creator/Author:
    Carr-Trebelhorn, Julia
    Submitter:
    Julia Carr-Trebelhorn
    License:
    Attribution-NonCommercial-NoDerivs 4.0 International
    0Collections
    2Works

  • Boston gas streetlights

    User Collection
    Collection thumbnail: Boston gas streetlights
    Type:
    Collection
    Description/Abstract:
    Methane emissions and other environmental and historical information about natural gas streetlights in Boston, Massachusetts
    Creator/Author:
    Townsend-Small, Amy
    Submitter:
    Amy Townsend-Small
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)
    0Collections
    2Works

  • Collaborative Convenings: Increasing Capacity in the Social Science Research Enterprise with HBCUs, PUIs, and More

    User Collection
    Collection thumbnail: Collaborative Convenings: Increasing Capacity in the Social Science Research Enterprise with HBCUs, PUIs, and More
    Type:
    Collection
    Description/Abstract:
    This collection includes a variety of resources compiled as a result of a study (#2324585) funded by the National Science Foundation. The study convened research-oriented and research enterprise professionals from social science fields, in a variety of ways, to discuss barriers, challenges, and solutions to increasing research funding at their institutions and beyond. Please see the "Helpful Online Resources" document for additional free resources. The organic repository will be reviewed and updated, if needed, annually. To suggest additional resources, please email  ImpactAccelerator@uc.edu. This material is based upon work supported by the National Science Foundation under Grant Number 2324585. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
    Creator/Author:
    Green-Schwartz, Clair
    Submitter:
    Clair Green-Schwartz
    License:
    Public Domain Mark 1.0
    0Collections
    8Works

  • Keeping Up Appearances: A Lacanian Perspective on American Mythmaking in Augustus Saint-Gaudens’ 'The Puritan' (1886)

    User Collection
    Collection thumbnail: Keeping Up Appearances: A Lacanian Perspective on American Mythmaking in Augustus Saint-Gaudens’ 'The Puritan' (1886)
    Type:
    Collection
    Description/Abstract:
    For Jacques Lacan, “psychoanalysis is the discipline which has reestablished the bridge linking modern man to the ancient myths.” This bridge towards myth that inevitably runs through the unconscious lays bare the scaffolding of culture. Famously, for Lacan, the unconscious is structured like a language, operating in one part through chains of signifiers which comprise a register of experience called the Symbolic. This Symbolic order, in relation to its two counterparts the Imaginary and the Real, is anchored by a fundamental signifier, the Symbolic Father, also called the Name-of-the-Father. Not necessarily a literal father, the Name-of-the-Father represents the lawgiving and morally punitive function that confers identity and legitimacy to the subject, in a clinical sense; culturally, it represents the guarantor of the laws, rules, and authority that comprise society. It imposes meaning. If repressed, meaning collapses, and the subject falls back into the Imaginary order, the order of fantasy. Augustus Saint-Gaudens’ towering bronze, 'The Puritan,' first unveiled in Springfield, Massachusetts on Thanksgiving Day in 1887, appears at first to exemplify the Name-of-the-Father as a dramatic consolidation of shared history and moral authority in an age of surfeited civic virtue. This is, however, only smoke and mirrors, a taste of the Lacanian Imaginary. In its embodiment of imagined Puritan virtue, it hides a dissonance between Puritanism, the artist, and an evolving nation struggling to define itself in its Gilded Age. Any meaningful study on The Puritan, particularly one dependent upon historical and social context, is indebted art historian Erika Doss. Her painstaking work in “Augustus Saint-Gaudens’s The Puritan: Founders’ Statues, Indian Wars, Contested Public Spaces, and Anger’s Memory in Springfield, Massachusetts” (2012) is a key interlocutor that provides rather crucial social and cultural contexts surrounding the statue. Where Doss presents a comprehensive socio-political account, this paper approaches The Puritan from a distinctly psychoanalytic perspective, expanding her insights through Lacanian theory. In doing so, I argue that, in the wake of cultural uncertainty following the American Civil War, Saint-Gaudens’ The Puritan (1886) functions as a compensatory and contradictory fantasy of moral authority; as a foreboding yet caricatural paternal archetype, it fails as a Lacanian signifier of the Symbolic Father, exposing the fragility and ultimately the neurosis of Gilded Age myth-making. Upon interrogation of The Puritan in the ideological significance of its patronage, its formal contradictions, and finally, its psychic disfigurement through parody, my paper uncovers how civic art does not simply reflect ideology, it actively constructs and performs it as a symptom of a myth-making society.
    Creator/Author:
    Reisser, Kristopher
    Submitter:
    Kristopher Reisser
    License:
    Public Domain Mark 1.0
    0Collections
    2Works

  • Globalization of The Adoration: Pilgrimage, Trade, and Shifting Perspectives within The Master of the Legend of Saint Lucy’s 'Adoration of the Magi' (c. 1480-85)

    User Collection
    Collection thumbnail: Globalization of The Adoration: Pilgrimage, Trade, and Shifting Perspectives within The Master of the Legend of Saint Lucy’s 'Adoration of the Magi' (c. 1480-85)
    Type:
    Collection
    Description/Abstract:
    Throughout the 15th century, depictions of the Adoration of the Magi began to take new forms. Merchants, pilgrims, and wealthy individuals were all part of a major shift in globalization, and this is reflected through the Adoration of the Magi (c. 1480-85) by the Master of the Legend of Saint Lucy. - Rather than adhering to a strictly European vision, the artist now includes elements which reflect the culmination of trade within 15th century Northern Europe. Although there is knowledge and understanding of the developments within depictions of the Adoration, Saint Lucy’s paintings asserts itself as a direct reflection of shifting ideals and a focus on a secularized vision. Scholars such as Dr. Jean C. Wilson and Dr. Yona Pinson have guided my research thus far, especially in terms of market practices in Bruges. While these scholars provide insightful information concerning free marks, globalization, and changing depictions of the Adoration, there is a lack of connectedness, which is necessary to establish the shift. - Specifically, I am addressing various panel paintings of the Adoration from ca. 1390-1485 to consider the impact of globalization of shifting trends and how this affects the region at large. My research focuses on how depictions of the Adoration vary based on time, place, and potential influences (such as geography, patrons, and use of painting). Adoration of the Magi survives as one of the first major scenes which has such an emphasis on expanding global markets and trade. In conclusion, this project, by closely examining marketplace standards, pilgrimage, shifting ideals of race, and a growing secular attitude to favor patrons, works to shed new light on 15th century adaptations of the Adoration of the Magi.
    Creator/Author:
    Wells, Maiana
    Submitter:
    Maiana Wells
    License:
    All rights reserved
    0Collections
    2Works

  • Cross Cultural Differences in Parental Feeding Practices - Prelim Survey Measures

    User Collection
    Collection thumbnail: Cross Cultural Differences in Parental Feeding Practices - Prelim Survey Measures
    Type:
    Collection
    Description/Abstract:
    Survey measures and consent documents for Mothers and Fathers in English and Spanish. All measures were translated into Spanish by a native speaker and back translated from Spanish into English in order to ensure language equivalence. Available documents: Father's Survey Packet - English.doc Father's Survey Packet - Mexican American in English.doc Father's Survey Packet - Spanish.doc Mother's Survey Packet - English.doc Mother's Survey Packet - Mexican American in English.doc Mother's Survey Packet - Spanish.doc Online Intro and Consent - English.doc Online Intro and Consent - Spanish.doc Survey Measures include: Acculturation/incorporation – Abbreviated Multidimensional Acculturation Scale (Zea, Asner-Self, Birman, & Buki, 2003). The AMAS-ZABB is a 42 item, self-report scale with Likert-type response options designed to assess three factors associated with acculturation in the United States and in the country of origin: identity, language competence, and cultural competence. Parenting style – The PPQ scale yields three continuous scores reflecting Baumrind’s (1971) three parenting styles of authoritative, authoritarian, and permissive. Parental feeding practices – 49-item questionnaire that measures 12 aspects of parental feeding behavior, including monitoring child food intake, using food to regulate the child’s emotions, using food as a reward, child control over feeding, teaching about nutrition, encouraging good habits, restricting child’s food intake for weight reasons, restricting child’s intake for health reasons, and modeling healthy eating habits. Child eating behaviors – A 35-item parent-report questionnaire that measures eight dimensions of eating style in children. These constructs include responsiveness to food, enjoyment of food, satiety responsiveness, slowness in eating, fussiness, emotional overeating, emotional undereating, and desire for drinks. Anti-fat attitudes – Crandall’s Anti-fat Attitudes Questionnaire (AFA; Crandall, 1994) will assess parents’ attitudes toward obesity. This measure consists of 13 Likert-type response items and includes three subscales: the evaluation and dislike of individuals who are fat, the controllability of weight/fat, and personal concerns and distress about weight or the prospect of becoming overweight. Parent’s concern about child overweight - Concern for child’s overweight and child’s underweight were measured by ten questions from two subscales derived from the Child Feeding Questionnaire. Perception of child’s body. Parents’ satisfaction with their child’s current body shape was assessed utilizing body silhouettes of children (Collins, 1991; Appendix F). Parents were asked to indicate which of the seven figures they feel most closely resembles their child and then rate the figure they would most like their child to resemble and the figure they would not like their child to resemble.
    Creator/Author:
    Oehlhof, Marissa
    Submitter:
    Marissa Oehlhof, PhD
    License:
    Attribution-NonCommercial-ShareAlike 4.0 International
    0Collections
    8Works

  • Co-Targeting KRASG12D and the HER family is efficacious in colorectal cancer

    User Collection
    Collection thumbnail: Co-Targeting KRASG12D and the HER family is efficacious in colorectal cancer
    Type:
    Collection
    Description/Abstract:
    Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide, with roughly 41% of CRC cases harboring a KRAS mutation. There have been significant advances with the advent of KRAS-targeted therapies; however, acquired resistance to KRAS-targeted treatments has occurred in other cancers, with mechanisms including increased HER family expression among other receptor tyrosine kinases. HER3, a member of the HER family that is kinase impaired, has been shown to be a resistance mechanism upon inhibition of the HER family and downstream targets including RAS/MEK/ERK and PI3K/AKT. Our study examines whether HER3 and mutant KRAS are viable co-targets. We find that KRAS mutations tend to co-occur with HER3 alterations in a large panel of cancers and in CRCs. Our results show that both total and activated HER3 levels increase in CRC patient derived organoids and cell lines after treatment with KRASG12D targeted agents, indicating that HER3 could be a potential adaptive response mechanism to KRAS-targeted therapy. Further, we found that genetic knock-down of KRAS and HER3 resulted in a statistically significant reduction in growth of CRC cells compared to single knockdown of either KRAS or HER3. We observed that kinase impaired HER3 binding partners, as assessed by immunoprecipitation, is cell dependent with EGFR binding HER3 in one cell line. After co-treating CRC cells with pan-HER inhibitors in combination with MRTX1133, a KRASG12D inhibitor, synergistic and additive effects in reduction in cell growth were observed in a drug-dependent manner. Finally, we found that co-targeting KRASG12D mutant cells with a KRASG12D inhibitor and a HER3 antibody-drug conjugate further reduced cell viability. We posit that co-targeting both KRASG12D and HER3, whether directly or indirectly, is a potential therapeutic strategy in CRC patients.
    Creator/Author:
    Garrett, Joan and Kilroy, Mary Kate
    Submitter:
    Joan Garrett
    License:
    Attribution 4.0 International
    0Collections
    2Works