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  • A New Sarcoidosis Diagnostic Score

    Student Work thumbnail: A New Sarcoidosis Diagnostic Score
    Type:
    Student Work
    Description/Abstract:
    Summary: The diagnosis of sarcoidosis is made by the combination of clinical features and biopsy results. The clinical features of sarcoidosis can be quite variable. We developed a Sarcoidosis Diagnostic Score (SDS) to summarize the clinical features of possible sarcoidosis patients. Biopsy confirmed sarcoidosis patients seen during a seven-month time period at the University of Cincinnati Sarcoidosis clinic were prospectively identified. Non-sarcoidosis patients seen at the same clinic were used as controls. Using a modified WASOG organ assessment instrument, we scored all patients for presence of biopsy, one or more highly probable symptom, and one or more at least probable symptom for each area. Two sarcoidosis scores were generated: SDS biopsy (with biopsy) and SDS clinical (without biopsy).The 980 evaluable patients were divided into two cohorts: an initial 600 patients (450 biopsy confirmed sarcoidosis, 150 controls) to establish cut-off values for SDS biopsy and SDS clinical and a validation cohort of 380 patients (103 biopsy confirmed sarcoidosis patients and 277 controls). The best cutoff value for SDS biopsy was > 6 (sensitivity =99.3%; specificity=100%). For the total the 980 patients, an SDS clinical > 3 had a sensitivity of 94.2%, specificity of 88.8%, and a likelihood ratio of 7.9. An SDS clinical score > 4 had a lower sensitivity of (76.9%) but higher specificity (98.6%). For sarcoidosis, the presence of specific clinical features, especially multi-organ involvement, can enhance the diagnostic certainty. The SDS scoring system quantitated the clinical features consistent with sarcoidosis. Awards/Publications: Published in CHEST Journal 2018 Oral presentation at the 2018 American Thoracic Society Conference
    Creator/Author:
    Lower, Elyse E., M.D.; Baughman, Robert P., M.D., and Bickett, Alexandra
    Submitter:
    Alexandra Bickett
    Date Uploaded:
    05/24/2018
    Date Modified:
    05/24/2018
    Date Created:
    2018-04-15
    License:
    Attribution-ShareAlike 4.0 International

  • Hematopoietic Development of iPSC Derived Human Liver Organoids

    Student Work thumbnail: Hematopoietic Development of iPSC Derived Human Liver Organoids
    Type:
    Student Work
    Description/Abstract:
    Human iPSCs (TkDA cell-line) were differentiated on laminin coated plates into endoderm by treatment of Activin and BMP, then treated with FGF4 and CHIR to further differentiate into posterior foregut. The cells were embedded into Matrigel droplets and cultured in Advanced DMEM. Droplet media was collected for ELISA to measure Albumin concentrations. The droplets were collected for histology and RNA isolation to test for AFP, ALB, and HBG1 genes. These methods resulted in the creation of a novel culture system containing both hepatic and hematopoietic lineage cells to model developing fetal liver.
    Creator/Author:
    Lewis, Kyle; Jallaq, Sahar, and Takebe, Takanori
    Submitter:
    Sahar Jallaq
    Date Uploaded:
    05/10/2018
    Date Modified:
    05/23/2019
    Date Created:
    2018-04
    License:
    All rights reserved

  • Creating Best Practices with Employer Partners

    Image thumbnail: Creating Best Practices with Employer Partners
    Type:
    Image
    Description/Abstract:
    Starting or growing a co-op/internship program can be intimidating; for both educators and potential employer partners. In an effort to learn the pain points for both parties, opportunities to break down barriers and build bridges, and identify actionable steps to get started, faculty from the University of Cincinnati’s Division of Experience-Based Learning and Career Education conducted a two-year research project with 65 co-op and internship employers from more 15 unique industry clusters, and 50 university faculty and staff representing 24 unique institutions. This poster will graphically share the resulting findings from more than 1250 qualitative responses, and generate discussion on the educational pedagogy of creating best practices for employer partners. Find out what “the survey says”!
    Creator/Author:
    Damschroder, Cindy
    Submitter:
    Cindy Damschroder
    Date Uploaded:
    01/15/2018
    Date Modified:
    05/23/2019
    Date Created:
    2017-10-29
    License:
    Public Domain Mark 1.0

  • Case record of children admitted to the House of Refuge, covering cases 1-321, October 25, 1850 through July 17, 1852 and cases 4909-5300, September 19, 1883 through September 7, 1885

    Document thumbnail: Case record of children admitted to the House of Refuge, covering cases 1-321, October 25, 1850 through July 17, 1852 and cases 4909-5300, September 19, 1883 through September 7, 1885
    Type:
    Document
    Description/Abstract:
    Digital scans of case records for admissions to the Cincinnati House of Refuge.
    Creator/Author:
    Cincinnati House of Refuge
    Submitter:
    Sean Crowe
    Date Uploaded:
    11/08/2017
    Date Created:
    1850
    License:
    Public Domain Mark 1.0

  • Spring's Mix

    Media thumbnail: Spring's Mix
    Type:
    Media
    Description/Abstract:
    Three part work created for my exhibition at Shirley Jones Gallery in Yellow Springs, Ohio. Features dance treatments from Experimental Television Center, as well as footage from my backyard on Riddle Rd in Cincinnati. The piece was projected onto the store front windows of the gallery.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/15/2016
    Date Modified:
    05/14/2019
    Date Created:
    2006
    License:
    All rights reserved

  • Arvo's Clouds

    Media thumbnail: Arvo's Clouds
    Type:
    Media
    Description/Abstract:
    Commissioned by the Concert Nova chamber music group in Cincinnati. I created this image to accompany a performance of "Fratres" by Arvo Part. The recording used on this version is by Kronos Quartet.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/15/2016
    Date Modified:
    05/07/2019
    Date Created:
    2010
    License:
    All rights reserved

  • Table of Elements

    Media thumbnail: Table of Elements
    Type:
    Media
    Description/Abstract:
    Table of Elements was specifically conceived and designed for use in a health care environment. The ideal situation for this work is in a hospital waiting room, "Table of Elements" attempts to shift the viewer’s experience away from the typical mode of watching a moving image and towards a way of observation more akin to the way in which we view a painting. I’m interested in creating a tension between the static and the dynamic. Initially the work may at times appear unchanging, although never static, and the piece, which at first may seem like it can be absorbed in a single glance, gradually reveals new dimensions of itself over time, or through repeated encounters. The work is exhibited as a diptych, with two synchronized video loops displayed on two adjacent monitors.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/15/2016
    Date Modified:
    05/13/2019
    Date Created:
    2012
    License:
    All rights reserved

  • Table of Elements Installed at University of Cincinnati Medical Center

    Media thumbnail: Table of Elements Installed at University of Cincinnati Medical Center
    Type:
    Media
    Description/Abstract:
    Documentation of the installation and of reactions to the work by people in the the hospital waiting room. Interviews by Melissa Godoy.
    Creator/Author:
    Woodman, Charles and Godoy, Melissa
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/14/2016
    Date Modified:
    05/07/2019
    Date Created:
    2014
    License:
    All rights reserved

  • Table of Elements 7 Minute Sample

    Media thumbnail: Table of Elements 7 Minute Sample
    Type:
    Media
    Description/Abstract:
    Short version with brief excerpts from the longer 150 minute work.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/14/2016
    Date Modified:
    05/07/2019
    Date Created:
    2012
    License:
    All rights reserved

  • Hamilton County Stable Integrated Communities: 2010 Update

    Article thumbnail: Hamilton County Stable Integrated Communities: 2010 Update
    Type:
    Article
    Description/Abstract:
    The previous study for which this one serves as an update concluded that there was good news for those who wished to live in racially integrated communities in Hamilton County. The news remains good. At the 2010 census, fifty-four suburban Hamilton County communities and Cincinnati neighborhoods, over one-third of the total, containing 45% of the total population of the county, were at least modestly racially integrated (Table 9).2 This continues trends that began as early as 1970 when seven communities achieved integration that persisted for at least forty years. At the 1980 census, twelve achieved racial integration that lasted for at least thirty years. And at the 1990 census, ten became integrated with that persisting for at least the next twenty years. Together, twenty-nine communities have remained racially integrated for at least twenty years. At the same time, the dissimilarity index (DI), a standard measure of residential integration, showed improved black/white integration for both the city of Cincinnati and Hamilton County as a whole (Table 1). Cincinnati’s DI dropped from 91.2 in 1950, its highest point, to 64.8 in 2010. Hamilton County’s DI dropped from 82.8 in 1980, the earliest for which we have data, to 71.3 in 2010. This means that increasing numbers of whites and blacks are living on the same blocks in a number of communities here. The desirability of these integrated neighborhoods has apparently remained steady over time. Although both the city and the county have lost population, the integrated neighborhoods have proportionally lost no greater population than the rest. Moreover, in the last decade, conventional wisdom to the contrary, several of the long-term integrated communities experienced increases in the white percentage of their population. When we looked at socio-economic conditions throughout the county as measured by seven indicators drawn from the census, we found a range of values for the integrated communities. Some are clearly in quite good shape and improving and some show signs of decay. On a scale that aggregates five of these indicators, integrated communities on the average fell between the values for the city of Cincinnati as a whole and for suburban Hamilton County. This is particularly good news as the declining economy has certainly hurt the African Americans population more than the rest of the population. Because of this, the integrated communities might be expected to show a greater decline than the rest of the county, and while some of them have been hurt, on the average, they seem to be holding their own in comparison to the rest of the county. Finally, the city of Cincinnati, which has long seen an increase in black population and a decrease in white population, in the 2000s saw a significant slow-down in the decline of white population and an actual decrease in black population. This suggests that the black/white ratio may stabilize in the city in the near future.
    Creator/Author:
    Casey-Leininger, Charles
    Submitter:
    Charles Casey-Leininger
    Date Uploaded:
    10/07/2014
    Date Modified:
    08/10/2016
    Date Created:
    2011-10
    License:
    All rights reserved