The present study deals with an AFCA (Adaptive Fuzzy Control Algorithm) for an Euler-Bemoulli approximation of a two-dimensional version of a cantilever beam-like orthogonal tetrahedral space truss. Transient disturbances, modeled as a unit impulse, excite all the modes of the beam. The resulting transverse displacement at the free end of the beam and its corresponding rate are observed by sensors placed there, and active control of the beam is provided by a collocated force actuator.
A design methodology, based on fuzzy logic which assumes no a priori knowledge of plant dynamics, for the closed-loop control algorithm results in relatively quick settling times, low overshoots and dying out of vibration within a few seconds. The control algorithm is enhanced and made much faster by eliminating the need of repeatedly solving the set of differential equations of motion of an emulated dynamic vibration absorber. When the control force is turned off after a mere 15 seconds, almost all the vibrational energy is dissipated as the beam returns to its undisturbed state throughout its length. In addition, the performance of the AFCA is insensitive to varying initial conditions. To examine the robustness of the control system to changes in the temporal dynamics of the cantilever beam, the transient disturbance response to a considerably perturbed plant is simulated. The Young's modulus of the beam was raised as well as lowered by 60%, substantially perturbing the natural frequencies of vibration compared to the nominal plant. The AFCA provided similar settling times and rates of vibrational energy dissipation, satisfying the aim of plant model independence.
OBJECTIVE: Damage to hair from UV exposure has been well reported in the literature and is known to be a highly complex process involving initiation via absorption of UV light followed by formation and propagation of reactive oxygen species (ROS). The objective of this work was to understand these mechanisms, explain the role of copper in accelerating the formation of ROS and identify strategies to reduce the hair damage caused by these reactive species.
METHODS: The location of copper in hair was measured by Transmission electron microscopy–(TEM) X-ray energy dispersive spectroscopy (XEDS) and levels measured by ICP-OES. Protein changes were measured as total protein loss via the Lowry assay, and MALDI ToF was used to identify the biomarker protein fragments. TBARS assay was used to measure lipid peroxide formation. Sensory methods and dry combing friction were used to measure hair damage due to copper and UV exposure and to demonstrate the efficacy of N,N’ ethylenediamine disuccinic acid (EDDS) and histidine chelants to reduce this damage.
RESULTS: In this work, a biomarker protein fragment formed during UV exposure is identified using mass spectrometry. This fragment originates from the calcium-binding protein S100A3. Also shown is the accelerated formation of this peptide fragment in hair containing low levels of copper absorbed from hair during washing with tap water containing copper ions. Transmission electron microscopy (TEM) X-ray energy dispersive spectroscopy (XEDS) studies indicate copper is located in the sulphur-poor endo-cuticle region, a region where the S100A3 protein is concentrated. A mechanism for formation of this peptide fragment is proposed in addition to the possible role of lipids in UV oxidation. A shampoo and conditioner containing chelants (EDDS in shampoo and histidine in conditioner) is shown to reduce copper uptake from tap water and reduce protein loss and formation of S100A3 protein fragment. In addition, the long-term consequences of UV oxidation and additional damage induced by copper are illustrated in a fourmonth wear study where hair was treated with a consumer relevant protocol of hair colouring treatments, UV exposure and regular shampoo and conditioning.
CONCLUSIONS: The role of copper in accelerating UV damage to hair has been demonstrated as well as the ability of chelants such as EDDS and histidine in shampoo and conditioner products to reduce this damage.
The purpose of this study is to plan and operate design-workshops based on project-based learning (PBL), and examine their educational value for students. The PBL workshop encour- ages direct participation from students and produces educational value, and it is important to raise the interest level of workshops to elicit proactive participation. The workshop in this study was carried out over two weeks in January 2017 at Korea’s Yonsei University. The workshop was composed of eight teams of students from three countries, including Korea, China, and Japan, and the course was primarily divided into two sessions. The workshop participants examined in this thesis were notably satised with the elements of the course meant to garner interest. In the questionnaire results, participants also indicated that they obtained ample educational value through the workshop. An important element of the workshop was to connect the participants with businesses, which is also an important component of design education. Despite this, participants expressed a relatively lower level of satisfaction com- pared to other elements of the workshop. The results and analysis of this study will hopefully become a meaningful resource for educators when designing workshops in the future.
Background: Role of apolipoprotein (apo) A-II on metabolism of high density lipoproteins (HDLs) is unknown.
Results: Conformational changes of apoA-I, the major apolipoprotein of HDL, caused by apoA-II in discoidal HDL are confined to two regions of apoA-I.
Conclusion: Interactions between the two major apolipoproteins in discoidal HDL are site specific.
Significance: Functional implications of HDL complexes will significantly benefit from such structural information.
This article features several books in the University of Cincinnati Libraries' collection that were previously in Nazi and other World War Two related libraries and explains how UCL came to acquire them through the Cooperative Acquisitions Project sponsored by the Library of Congress after the war.
UAV’s are being increasingly used today than ever before in both military and civil applications. A certain level of autonomy is imperative to the future of UAV’s. A quadrotor is a helicopter with four rotors, that make it more stable; but more complex to model and control. Characteristics that provide a clear advantage over other fixed wing UAV’s are VTOL and hovering capabilities as well as a greater maneuverability. Fuzzy logic control has been chosen over conventional control methods as it can deal effectively with highly nonlinear systems, allows for imprecise data and is extremely modular. The objective of this research endeavor is to present the steps of designing, building and simulating an intelligent flight control module for a quadrotor UAV. Validation of the math model developed is discussed using actual flight data. Excellent attitude tracking is demonstrated for near hover flight regimes. System design is comprehensively dealt with. The responses are analyzed and future work involving hardware-in-the-loop simulations is proposed.
Hyperelastic constitutive models of soft tissue mechanical behavior are extensively used in applications like computer-aided surgery, injury modeling, etc. While numerous constitutive models have been proposed in the literature, an objective method is needed to select a parsimonious model that represents the experimental data well and has good predictive capability. This is an important problem given the large variability in the data inherent to soft tissue mechanical testing.
In this work, we discuss a Bayesian approach to this problem based on Bayes factors. We propose a holistic framework for model selection, wherein we consider four different factors to reliably choose a parsimonious model from the candidate set of models. These are the qualitative fit of the model to the experimental data, evidence values, maximum likelihood values, and the landscape of the likelihood function. We consider three hyperelastic constitutive models that are widely used in soft tissue mechanics: Mooney-Rivlin, Ogden and exponential. Three sets of mechanical testing data from the literature for agarose hydrogel, bovine liver tissue, porcine brain tissue are used to calculate the model selection statistics. A nested sampling approach is used to evaluate the evidence integrals. In our results, we highlight the robustness of the proposed Bayesian approach to model selection compared to the likelihood ratio, and discuss the use of the four factors to draw a complete picture of the model selection problem.
Throughout much of his career the Anglo-Jewish historian Cecil Roth visited the U.S. and lectured to American Jewish students. Indeed, his first academic appointment was as a visiting professor at the Jewish Institute in Religion in New York City, and he was a regular teacher at the summer institutes of the Intercollegiate Menorah Society. Yet, he only wrote one short article (in 1963) that focused exclusively on American Jewish history, which was commissioned by Jacob Rader Marcus, the “Dean of American Jewish Historians.” An examination of Roth’s correspondence over a thirty plus year period reveals that his discussions of the nature and purpose of Jewish history was largely shaped by his relationship with American Jewry.
This paper engages with the literature to present different perspectives between forecasting and foresight in strategic design, while drawing insights derived from futures studies that can be applied in form of a design-inspired foresight approach for designers and interdisciplinary innovation teams increasingly called upon to help envisage preferable futures. Demonstrating this process in applied research, relevant examples are drawn from a 2016 Financial Services industry futures study to the year 2030. While the financial services industry exemplifies an ideal case for design-inspired foresight, the aims of this paper are primarily to establish the peculiarities between traditional forecasting applications and a design-inspired foresight visioning approach as strategic design activities for selecting preferable futures. Underlining the contribution of this paper is the
value of design futures thinking as a creative and divergent thought process, which has the potential to respond to the much broader organizational reforms needed to sustain in today’s rapidly evolving business environment (Buchanan, 2015; Irmak, 2005; Muratovski, 2016).
There has been a lot of discussion and application of social media marketing in libraries. Not surprisingly, many libraries manage multiple social media accounts on top of traditional marketing strategies. However, not many libraries have developed a strategic digital marketing strategy that synthesizes areas such as video marketing, email marketing, search engine optimization (SEO), mobile marketing, and even outreach through traditional marketing channels. These additional digital marketing channels are equally as important as social media, yet play different roles in attracting, retaining, and engaging users. As users spend an increasing amount of time online searching, it is essential for them to identify the right library resources in a search engine, find the right event in their email and social media, and develop a sense of loyalty through valuable content generated in videos and blogs. Planning for channel overlap as well as users that a campaign may have missed is an essential part of this strategy. This paper is intended to provide an overview of the multi-channel digital marketing landscape and its application in libraries. Recommended actions are provided as well.
The term “community-based participatory design” (CBPD) recently emerged as a distinctive space in the Participatory Design tradition (DiSalvo, Clement & Pipek, 2013; LeDantec, 2016). This move marks a shift from treating the process of design primarily as a product development method, to one that builds social and technical capacities – or infrastructures – of individuals and communities (Björgvinsson, Ehn, & Hillgren 2010; Karasti 2014; LeDantec 2016). This paper describes participant gains from a design workshop conducted as part of a research collaboration involving a university-based research center, and four NGOs, the participatory design workshop aimed to: (1) build the capacities of young people; (2) guide young people in the creation of novel and locally relevant gender and sexual and reproductive health (SRH) solutions; and, (3) bring voices of young people into research and programmatic questions around gender and SRH in the public health domain. The workshop was conducted with 31 young people aged 15-25, over 2.5 weeks, in Lucknow, Uttar Pradesh, India. The evaluation demonstrates that the workshop resulted in exposure to working in mixed-gender teams, developing problem-solving skills, and increasing SRH awareness and knowledge. The workshop produced six low-fidelity prototypes, five of which were subsequently refined and piloted by three Lucknow NGOs.
Cardiolipin (CL) is a mitochondrial phospholipid essential for electron transport chain (ETC) integrity. CL-deficiency in humans is caused by mutations in the tafazzin (Taz) gene and results in a multisystem pediatric disorder, Barth syndrome (BTHS). It has been reported that tafazzin deficiency destabilizes mitochondrial respiratory chain complexes and affects supercomplex assembly. The aim of this study was to investigate the impact of Taz-knockdown on the mitochondrial proteomic landscape and metabolic processes, such as stability of respiratory chain supercomplexes and their interactions with fatty acid oxidation enzymes in cardiac muscle. Proteomic analysis demonstrated reduction of several polypeptides of the mitochondrial respiratory chain, including Rieske and cytochrome c1 subunits of complex III, NADH dehydrogenase alpha subunit 5 of complex I and the catalytic core-forming subunit of F0F1-ATP synthase. Taz gene knockdown resulted in upregulation of enzymes of folate and amino acid metabolic pathways in heart mitochondria, demonstrating that Tazdeficiency causes substantive metabolic remodeling in cardiac muscle. Mitochondrial respiratory chain supercomplexes are destabilized in CL-depleted mitochondria from Taz knockdown hearts resulting in disruption of the interactions between ETC and the fatty acid oxidation enzymes, very long-chain acyl-CoA dehydrogenase and long-chain 3-hydroxyacylCoA dehydrogenase, potentially affecting the metabolic channeling of reducing equivalents between these two metabolic pathways. Mitochondria-bound myoglobin was significantly reduced in Taz-knockdown hearts, potentially disrupting intracellular oxygen delivery to the oxidative phosphorylation system. Our results identify the critical pathways affected by the Taz-deficiency in mitochondria and establish a future framework for development of therapeutic options for BTHS.
Cardiac myosin binding protein-C (cMyBP-C) is a thick filament assembly protein that stabilizes sarcomeric structure and regulates cardiac function; however, the profile of cMyBP-C degradation after myocardial infarction (MI) is unknown. We hypothesized that cMyBP-C is sensitive to proteolysis and is specifically increased in the bloodstream post-MI in rats and humans. Under these circumstances, elevated levels of degraded cMyBP-C could be used as a diagnostic tool to confirm MI. To test this hypothesis, we first established that cMyBP-C dephosphorylation is directly associated with increased degradation of this myofilament protein, leading to its release in vitro. Using neonatal rat ventricular cardiomyocytes in vitro, we were able to correlate the induction of hypoxic stress with increased cMyBP-C dephosphorylation, degradation, and the specific release of N′-fragments. Next, to define the proteolytic pattern of cMyBP-C post-MI, the left anterior descending coronary artery was ligated in adult male rats. Degradation of cMyBP-C was confirmed by a reduction in total cMyBP-C and the presence of degradation products in the infarct tissue. Phosphorylation levels of cMyBP-C were greatly reduced in ischemic areas of the MI heart compared to non-ischemic regions and sham control hearts. Post-MI plasma samples from these rats, as well as humans, were assayed for cMyBP-C and its fragments by sandwich ELISA and immunoprecipitation analyses. Results showed significantly elevated levels of cMyBP-C in the plasma of all post-MI samples. Overall, this study suggests that cMyBP-C is an easily releasable myofilament protein that is dephosphorylated, degraded and released into the circulation post-MI. The presence of elevated levels of cMyBP-C in the blood provides a promising novel biomarker able to accurately rule in MI, thus aiding in the further assessment of ischemic heart disease.
Intelligent Application if defined technically is a strategy that uses hyper-personalized mobile app experiences and services and knowledge-extraction processes to increases the user experience (Jessica Ekholm, 2017). In simple words, the applications that not only know how to support or enable key decisions but also continually learn from the user interactions to become even more relevant and valuable to those users, are known as Intelligent apps. Such applications are smart enough to differentiate between relevant and irrelevant information with the help of AI algorithms. Moreover, these apps have the capability to ease the complex task into the as simple task as a single touch.
A short computational program was undertaken to evaluate the effectiveness of a closed-loop control strategy for the stabilization of an unstable bluff-body flow. In this effort, the non-linear one-dimensional Ginzburg–Landau wake model at 20% above the critical Reynolds number was studied. The numerical model, which is a non-linear partial differential equation with complex coefficients, was solved using the FEMLAB®/MATLAB® software packages and validated by comparison with published literature. At first, a model independent approach was attempted for wake suppression using feedback control. The closed-loop system was controlled using a conventional proportional-integral-derivative (PID) controller as well as a non-linear fuzzy controller. A single sensor is used for feedback, and the actuator is represented by altering the boundary conditions of the cylinder. Simulation results indicate that for a single sensor scheme, the increase in the sophistication of the control results in significantly shorter settling times. However, there is only a marginal improvement concerning the suppression of the wake at higher Reynolds numbers. The feedback control design was then augmented by switching over to a model-dependent controller. Based on computationally generated data obtained from solving the unforced wake, a low-dimensional model of the wake was developed and evaluated. The low-dimensional model of the unforced Ginzburg–Landau equation captures more than 99.8% of the kinetic energy using just two modes. Two sensors, placed in the absolutely unstable region of the wake, are used for real-time estimation of the first two modes. The estimator was developed using the linear stochastic estimation scheme. Finally, the loop is closed using a PID controller that provides the command input to the variable boundary conditions of the model. This method is relatively simple and easy to implement in a real-time scenario. The control approach, applied to the 300 node FEMLAB® model at 20% above the unforced critical Reynolds number stabilizes the entire wake. Compared to the model-independent controllers, the controller based on the low-dimensional model is far more effective in the suppression of the wake at higher Reynolds numbers. Furthermore, while the latter approach employs only the estimated temporal amplitude of the first mode of the imaginary part of the amplitude, all higher modes are stabilized. This suggests that the higher order modes are caused by a secondary instability that is suppressed once the primary instability is controlled.
Closed-loop control strategies were studied experimentally at low Reynolds and incompressible Mach numbers using periodic excitation to vector a turbulent jet. Vectoring was achieved by attaching a short, wide-angle diffuser at the jet exit and introducing periodic excitation from a slot covering one quadrant of the circumference of the round turbulent jet. Closed-loop control methods were applied to transition quickly and smoothly between different jet de ection angles. The frequency response of the zero-mass- ux piezoelectric actuatorwas at to about 0.5 kHz, but the jet responds up to 30–50 Hz only. This is still an order of magnitude faster than conventional thrust vectoring mechanism. System identi cation procedures were applied to approximate the system’s transfer function. A linear controller was designed that enabled fast and smooth transitions between stationary de ection angles and maintained desired jet vectoring angles under varying system conditions. The linear controller was tested over the entire range of available de ection angles, and its performance is evaluated and discussed.
The “Safety Grand Challenge” is a collaborative research project between the Royal College of Art (RCA) School of Design, and the Lloyd's Register Foundation (LRF). The maritime industry is dominated by “grandfathering” leading to a slow-pace of adopting innovations that can reduce risk and save lives at sea. We describe how impact was achieved through collaboration and design innovations that bridged the risk gap between technologies and human behaviours. Starting from the project brief we designed a collaborative platform that supported a constructive dialogue between academia and partner organisations that aimed to foster innovative design approaches to risk and safety. The project generated an engaged community with diverse expertise that influenced the outcomes which included seven prototypes designed by a group of thirty students from across the RCA. Throughout the course of the project the network extended to other partners beyond the initial ones that included the RCA, LRF and Royal National Lifeboat Institution. The “Safety Grand Challenge” demonstrates how research can be an explorative platform that offers opportunities to analyse and design solutions to real life safety problems in mature industries through the prototypes that reflect the sophistication of the project’s collaborations. Our conclusions support how design research helped identify the value of design for safety in tackling complex issues that intertwine human, environmental and commercial views and can shape new forms of collaborative research between academia and industrial partners.