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  • Activation of a branched chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness

    Article thumbnail: Activation of a branched chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness
    Type:
    Article
    Descripción/Resumen:
    Adult hematopoietic stem cells (HSCs) sustain the lifelong production of all mature blood and immune cells. HSCs possess extensive regenerative potential, but their self-renewal is limited. A long-standing question has been why replicative history negatively impacts HSC functions. We found that accrued divisions alter HSC production; generating low-output bone-marrow landscapes that are highly variable in lineage contribution and transcriptionally divergent within individual lineages. Division-driven HSC functional alterations arise from redirecting branched chain amino acid (BCAA) usage from catabolic towards anabolic activity, causing faster HSC cell cycle kinetics. Adding a BCAA transamination product overcomes the BCAA catabolic checkpoint and slows down the cell cycle, durably rescuing balanced lineage output of HSCs with accrued divisions. Hence, our study suggests the paradigm whereby replicative history causes metabolic and transcriptional drift, generating divergent HSC output. Division-dependent HSC functional drift can be restored by metabolite replacement, which has long-term therapeutic implications for HSC regenerative medicine.
    Creador/Autor:
    H. Leighton Grimes; Sydney Treichel; Madeline Frangiosa; Waseem Nasr; Marie-Dominique Filippi; Juying Xu; Nathan Salomonis; Baobao Song; Andrew Harley; Devyani Sharma; James Bartram; Angelo D’Alessandro, and Travis Nemkov
    Peticionario:
    Marie-Dominique Filippi
    Fecha modificada:
    06/26/2026
    Fecha modificada:
    06/26/2026
    Licencia:
    Attribution-ShareAlike 4.0 International

  • Targeted After Generative (TAG) Learning for Causal Inference with Latent Variables

    Article thumbnail: Targeted After Generative (TAG) Learning for Causal Inference with Latent Variables
    Type:
    Article
    Descripción/Resumen:
    Latent variables and causal inference are central to implementing empirical research and advancing substantive theory across the social sciences. Conventional latent variable frameworks such as structural equation modeling (SEM) are constrained by several simplifying assumptions (e.g., linearity, additivity, correct model specification). In this study, we relax key SEM assumptions by building data adaptive estimation methods for causal inference with latent variables. We developed a theory-driven Targeted After Generative (TAG) learning framework that integrates SEM-informed variational autoencoders (SEM VAEs) with targeted machine learning to estimate the average treatment effect. On the generative side, the SEM VAE encodes theory aligned neural networks that learn latent variable distributions through flexible joint modeling of measurement and structural parameters. On the targeted learning side, we construct an efficient influence function for the treatment effect with the SEM-VAE implied posterior distribution of the latent variables to estimate the average effect. Across simulations, the TAG learning approach outperforms alternative approaches and demonstrates low to no bias even in adverse conditions. TAG learning offers a theory-driven flexible approach with methodological promise for causally interpretable data-adaptive analysis with latent variables. More practically, the framework allows estimation of causal effects involving latent variables even in the presence of unknown functional relationships in the measurement and structural models (e.g., data adaptive effect estimation for nonlinear/nonadditive SEMs).
    Creador/Autor:
    Kelcey, Ben; Ataneka, Amota, and Habarurema, Jean-Baptiste
    Peticionario:
    Ben Kelcey
    Fecha modificada:
    06/02/2026
    Fecha modificada:
    06/03/2026
    Fecha de creacion:
    05-20-26
    Licencia:
    Attribution 4.0 International

  • Archaeometric Study of Kentucky Redware and Bricks at the 1820s Historic Ingels Family Bourbon County Farm and Pottery Site

    Article thumbnail: Archaeometric Study of Kentucky Redware and Bricks at the 1820s Historic Ingels Family Bourbon County Farm and Pottery Site
    Type:
    Article
    Descripción/Resumen:
    This archeometric study analyzed local clay deposits at the Ingels Family Farm, settled in the Early Nineteenth Century in Bourbon County Kentucky. The redware pottery made on site was bartered and sold in the region, and the clay deposits were also used to make the bricks that constructed the 1820 Ingels family residence, still extant as of May 2026. Numerous materials characterization techniques including XRD, XRF, DTA/TGA, Spectroscopy, wet chemical analysis, and SEM were used to determine the characteristics of the local clay deposit and the identifying characteristics of the redware. The study also tested the wares to determine an approximate firing range, which was consistent with the requirements of low-to-mid fired earthenware. This study was done using archaeological materials from a previous archaeological investigation of the farm, but new material was added with the assistance the USDA Soil Survey Office in Kentucky, who drilled core samples for the project in Spring 2012.
    Creador/Autor:
    Carr-Trebelhorn, Julia; O'Malley, Nancy, Assistant Director, University of KY Museum of Anthropology, and Eitel, Richard, University of KY Department of Materials Science
    Peticionario:
    Julia Carr-Trebelhorn
    Fecha modificada:
    05/30/2026
    Fecha modificada:
    05/30/2026
    Fecha de creacion:
    2013-05-01
    Licencia:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • Virtual cybersecurity testbeds for industrial Internet of Things

    Article thumbnail: Virtual cybersecurity testbeds for industrial Internet of Things
    Type:
    Article
    Descripción/Resumen:
    Modern industrial equipment are networked to interact with both internal and external systems, enabling automated decision-making with minimal or no human intervention. While this new environment creates efficiencies, it exposes the environment to cyber threats. This chapter explores the use of cybersecurity testbeds to study best practices in architecting and defending environments that contain industrial systems. Cybersecurity testbeds – physical, virtual, and hybrid – are used in different sectors for research and validation. Virtual testbeds hold promise as they enable design flexibility, reconfiguration, and scale to support various types of research studies. This chapter discusses the value of virtual cybersecurity testbeds and demonstrates a case study on the use of virtual testbeds using a simple industrial control system and a common attack. The concepts apply to more complex set ups and more complex attack structures. Virtual cybersecurity testbed can support researchers, practitioners, and educators interested in defending critical infrastructure environments and industrial systems.
    Creador/Autor:
    Mandalapu, Rohit
    Peticionario:
    Rohit Mandalapu
    Fecha modificada:
    05/19/2026
    Fecha modificada:
    05/19/2026
    Licencia:
    Open Data Commons Open Database License (ODbL)

  • title

    Article thumbnail: title
    Type:
    Article
    Descripción/Resumen:
    title
    Creador/Autor:
    Platts, Christopher
    Peticionario:
    Christopher Platts
    Fecha modificada:
    04/27/2026
    Fecha modificada:
    04/27/2026
    Fecha de creacion:
    2026
    Licencia:
    CC0 1.0 Universal

  • The Language of the Self: Rejecting the Surrealist focus on Psychoanalysis in Leonora Carrington’s Self-Portrait (Inn of the Dawn Horse)

    Article thumbnail: The Language of the Self: Rejecting the Surrealist focus on Psychoanalysis in Leonora Carrington’s Self-Portrait (Inn of the Dawn Horse)
    Type:
    Article
    Descripción/Resumen:
    This project will explore the artist Leonora Carrington’s Self-portrait (Inn of the Dawn Horse, ca. 1937-38) and its relationship to and rejection of the male-centric, sexist ideology of psychoanalysis that governed the Surrealist movement. As outlined in Andre Breton's First Manifesto of Surrealism (1924), Freudian psychoanalysis had a great influence on Breton, the movement's founder (1896-1966). He believed in Freud's tenets and theories regarding dreams and the unconscious as a liberating and radical force that could tear down society’s systems of oppression. Yet there is a willful ignorance in Breton’s philosophy on the deep-rooted misogyny of Freud’s psychology and how the institution of psychoanalysis ignores the realities of female development and existence within inherently sexist societal structures of that period. However, Leonora Carrington rejected psychoanalytic theory as it pertained to her art. She refused to be categorized within sexist ideologies and asserted herself as a creative artist with her own interpretations of her work, positing her own ideologies in the process. She demonstrated her identity through her work and found liberation by developing her own feminist consciousness. Through researching Carrington's work, I want to expand on her ability to challenge the sexist paradigms of Surrealism and to reaffirm how her rejection demonstrates that female nonconformity is not only revolutionary but also necessary for female artistic freedom today. Other scholars have delved into this driving aspect of Carrington’s work but I will be utilizing Helene Cixous’ concept of “ecritutre feminine” in order to demonstrate how Carrington developed a “pictorial language” of her own within her work Self-Portrait (Inn of the Dawn Horse). I will use Cixous’ seminal work, "The Laugh of the Medusa," to expand on this idea and how Carrington developed that language, constituted of her own personal symbols, which is on full display in her self-portrait.
    Creador/Autor:
    Morriss, Ella
    Peticionario:
    Ella Morriss
    Fecha modificada:
    04/26/2026
    Fecha modificada:
    04/26/2026
    Fecha de creacion:
    2026-04-27
    Licencia:
    CC0 1.0 Universal

  • SAMPLE

    Article thumbnail: SAMPLE
    Type:
    Article
    Descripción/Resumen:
    SAMPLE
    Creador/Autor:
    Rose, Emma
    Peticionario:
    Emma Rose
    Fecha modificada:
    04/26/2026
    Fecha modificada:
    04/26/2026
    Fecha de creacion:
    April 26, 2026
    Licencia:
    CC0 1.0 Universal

  • After Brongniart: Defining the Word “Ceramic” and the Persistence of “Burnt Stuff”

    Article thumbnail: After Brongniart: Defining the Word “Ceramic” and the Persistence of “Burnt Stuff”
    Type:
    Article
    Descripción/Resumen:
    As I have previously shown, Alexandre Brongniart established a coherent science of ceramics. By the mid-nineteenth century, Brongniart had popularised the term "la céramique" as a widely-applicable name for the field of pottery and porcelain making, and other related arts. In the Twentieth Century, ceramic manufacturing became increasingly technical. The inclusive field of artisans and industrialists that Brongniart had once envisioned was fracturing. Voices called for the separation of pottery making from experimental, industrial ceramics and the meaning of the term “ceramics” was hotly debated. Numerous etymologies were traced, but, as the predominant language of science transferred from French to English, none of the twentieth-century authors recognized Brongniart’s key role in the invention of the term. Critically, this language debate coincided with and reflected the global politics, nationalism, and warfare of the first half of the Twentieth Century.
    Creador/Autor:
    Carr-Trebelhorn, Julia
    Peticionario:
    Julia Carr-Trebelhorn
    Fecha modificada:
    03/09/2026
    Fecha modificada:
    03/09/2026
    Fecha de creacion:
    2026-03-09
    Licencia:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • Alexandre Brongniart and the Arts of the Earth: Coining “La Céramique”

    Article thumbnail: Alexandre Brongniart and the Arts of the Earth: Coining “La Céramique”
    Type:
    Article
    Descripción/Resumen:
    Taking on the task of ordering the sciences related to pottery and clay-based objects, natural historian and porcelainier Alexandre Brongniart sought a new way of describing the ancient practice. Early in his forty-seven-year career as director of the Sèvres Porcelain Manufactory, Brongniart developed a research center for the advanced study of pottery and porcelain making. Brongniart recognized that an inclusive and distinct term for the field was necessary, but it had to be introduced carefully, so that it was welcomed rather than rejected as presumptuous. Through close reading of Brongniart’s writings, as well as contemporary periodicals and the texts of other authors, the development of the word “ceramic” – originally introduced by Brongniart and his associates in French as “la céramique” – can be traced closely. I show that this was a deliberate, methodical, and years-long effort to create a durable, comprehensive term.
    Creador/Autor:
    Carr-Trebelhorn, Julia
    Peticionario:
    Julia Carr-Trebelhorn
    Fecha modificada:
    03/09/2026
    Fecha modificada:
    03/09/2026
    Fecha de creacion:
    2026-03-09
    Licencia:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • Advancements in automated nuclei segmentation for histopathology using you only look once-driven approaches

    Article thumbnail: Advancements in automated nuclei segmentation for histopathology using you only look once-driven approaches
    Type:
    Article
    Descripción/Resumen:
    Histopathology image analysis plays a pivotal role in disease diagnosis and treatment planning, relying heavily on accurate nuclei segmentation for extracting vital cellular information. In recent years, artificial intelligence (AI) and in particular deep learning models have been applied successfully in solving computational pathology image analysis tasks. The You Only Look Once (YOLO) object detection framework, which is based on a convolutional neural network (CNN) architecture has gained traction across various domains for its real-time processing capabilities. This systematic review aims to comprehensively explore and evaluate the advancements, challenges, and applications of YOLO-based methodologies in nuclei segmentation within the domain of histopathological images. The review encompasses a structured analysis of recent literature, focusing on the utilization of YOLO variants for nuclei segmentation. Key methodologies, training strategies, dataset specifics, and performance metrics are evaluated to elucidate the strengths and limitations of YOLO in this context. Additionally, the review highlights the unique characteristics of YOLO that enable efficient object detection and delineation of nuclei structures, offering a comparative analysis against traditional segmentation approaches. This systematic review underscores the promising outcomes achieved through YOLO-based architectures, emphasizing their potential for accurate and rapid nuclei segmentation. Furthermore, it identifies persistent challenges such as handling variances in nuclei appearances, optimizing model architectures for histopathological images, and improving generalization across diverse datasets. Insights derived from this review can provide a foundation for future research directions and enhancements in nuclei segmentation methodologies using YOLO within histopathology, fostering advancements in disease diagnosis and biomedical research.
    Creador/Autor:
    Debsarkar, Shyam
    Peticionario:
    Shyam Debsarkar
    Fecha modificada:
    12/28/2025
    Fecha modificada:
    12/28/2025
    Fecha de creacion:
    March 25, 2025
    Licencia:
    All rights reserved