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  • The Evolving Role of the Library in Research

    Document thumbnail: The Evolving Role of the Library in Research
    Type:
    Document
    Description/Abstract:
    Acquiring, organizing, making accessible, and preserving information and data, including faculty archives, university records, theses/dissertations, and other output created by the university, is the library’s reason-for-being. Paper Submitted to ARN Envisioning the Future as Critical Partners in Data-Driven Science Workshop
    Creator/Author:
    Marine, Stephen
    Submitter:
    Stephen Marine
    Date Uploaded:
    12/08/2016
    Date Modified:
    12/08/2016
    Date Created:
    2013-04-18
    License:
    Attribution-NoDerivs 4.0 International

  • For Good Measure: The Role of Regulatory Records in Environmental Maintenance

    Document thumbnail: For Good Measure: The Role of Regulatory Records in Environmental Maintenance
    Type:
    Document
    Description/Abstract:
    This paper presented as part of the session "Infrastructures of Maintenance: Animals, Regulations and Expertise" at the Society for the History of Technology annual meeting, Philadelphia, PA.
    Creator/Author:
    Arnold, Hillel and Tansey, Eira
    Submitter:
    Eira Tansey
    Date Uploaded:
    01/05/2018
    Date Modified:
    01/05/2018
    Date Created:
    2017-10-27
    License:
    Attribution-NonCommercial-ShareAlike 4.0 International

  • Tao Te Ching

    Document thumbnail: Tao Te Ching
    Type:
    Document
    Description/Abstract:
    The new adaptation of the Tao Te Ching is a book of 81 chapters designed to be used in teaching tai chi.
    Creator/Author:
    Porte, Michael; Lao Tzu
    Submitter:
    Michael Porte
    Date Uploaded:
    03/07/2018
    Date Modified:
    03/07/2018
    Date Created:
    2005-01-20.
    License:
    All rights reserved

  • Call for Participation

    Document thumbnail: Call for Participation
    Type:
    Document
    Description/Abstract:
    Call for Participation- call for papers
    Creator/Author:
    Vogel, Craig and Fernandez, Oscar
    Submitter:
    Lora Alberto
    Date Uploaded:
    03/05/2018
    Date Modified:
    04/24/2018
    Date Created:
    2017-10-31
    License:
    Attribution-NonCommercial 4.0 International

  • EndNote X8 Workbook

    Document thumbnail: EndNote X8 Workbook
    Type:
    Document
    Description/Abstract:
    This document is a workshop workbook for EndNote X8, a citation and reference management software product. The workbook provides descriptions and exercises for most of the major features of EndNote, including program customization, importing & exporting data, organization and management of data, full text recovery & management, cite-while-you-write utility and EndNote Online.
    Creator/Author:
    Roberts, Randall
    Submitter:
    Randall Roberts
    Date Uploaded:
    01/23/2019
    Date Modified:
    05/23/2019
    Date Created:
    2017-02-20
    License:
    Attribution-NonCommercial 4.0 International

  • Researcher Services: Proposal to Increase Distinctive Excellence

    Document thumbnail: Researcher Services: Proposal to Increase Distinctive Excellence
    Type:
    Document
    Description/Abstract:
    This document details our process for creating a service catalog for UC Libraries Research and Data Services and our efforts towards offering data science services. In this document, we identify our gaps in knowledge and expertise while making recommendations for filling these gaps.
    Creator/Author:
    Koshoffer, Amy; Baldwin, Ted; Burgess, Kristen, and Grant, Tiffany
    Submitter:
    Tiffany Grant
    Date Uploaded:
    02/05/2019
    Date Modified:
    02/05/2019
    License:
    Attribution-NonCommercial 4.0 International

  • Durres Notebook Team A Vol 1

    Document thumbnail: Durres Notebook Team A Vol 1
    Type:
    Document
    Description/Abstract:
    One half of the field notebook for Team A for the Durrës Regional Archaeological Project (DRAP). Data from this field notebook were entered into the project database. This records the condition of the tracts walked including environmental data, as well as sketches describing the tract and artifact counts.
    Creator/Author:
    Wolpert, Aaron
    Submitter:
    John Wallrodt
    Date Uploaded:
    10/25/2016
    Date Modified:
    10/25/2016
    License:
    Attribution 4.0 International

  • Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocsytis carinii

    Document thumbnail: Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocsytis carinii
    Type:
    Document
    Description/Abstract:
    Fungi in the genus Pneumocystis are the cause of a potentially life threatening pneumonia, Pneumocystis pneumonia (PCP). The understanding of the lifecycle, metabolism, and drug development has been hindered due to a lack of a long term in vitro culture system. Unlike most other fungi, members of the genus Pneumocystis do not appear to synthesize the major fungal sterol, ergosterol. However, genome scans and in vitro assays suggest the presence of functional genes involved in a sterol pathway. One of the goals of this work was to characterize the P. carinii sterol enzyme, lanosterol synthase (Erg7p), an essential enzyme of the sterol pathway. The activity of P. carinii Erg7p was assessed by heterologous expression of P. carinii Erg7p in a Saccharomyces cerevisiae Erg7p null mutant. Growth rates and lanosterol production were similar between S. cerevisiae expressing the P. carinii enzyme and S. cerevisiae expressing its own Erg7p under the same conditions, indicating that not only does P. carinii produce a functional Erg7p, but also that the enzyme functionally complements the S. cerevisiae enzyme. Western blotting and fluorescent localization studies revealed that P. carinii Erg7p localizes to lipid particles in S. cerevisiae as does S. cerevisiae Erg7p. A novel finding of these studies, was that P. carinii contains lipid particles, and that P. carinii Erg7p localizes to lipid particles in P. carinii. These studies indicate that P. carinii Erg7p functions similar to the S. cerevisiae enzyme, and may perform a similar function in P. carinii. Biochemical analyses of sterols within the membranes of P. carinii have shown that it utilizes cholesterol rather than ergosterol as its bulk sterol. However, P. carinii does not appear to synthesize cholesterol from a de novo pathway, but rather scavenges exogenous sterols from its mammalian host. S. cerevisiae is induced to undergo sterol scavenging under anaerobic conditions. Consequently, another goal of this work was to provide information on the effect of O2 on sterol biosynthesis and sterol scavenging by P. carinii. ATP measurements revealed that the viability of P. carinii is severely decreased when maintained under hypoxic conditions, and this decrease correlated with an increase in drug susceptibility. We show that uptake of exogenous cholesterol by P. carinii occurred under normal O2 tensions, indicating that sterol scavenging is not limited to anaerobic conditions. Microarray analysis indicated that hypoxic maintenance of P. carinii resulted in decreased transcription of several genes involved in sterol and lipid biosynthesis suggesting that while hypoxic conditions down-regulated genes involved in sterol biosynthesis, down-regulation of sterol biosynthesis is not a requirement for sterol scavenging in P. carinii. The ability of P. carinii to scavenge exogenous sterols under normal O2 tensions at which the sterol pathway is unaffected provides evidence that sterol scavenging may be the primary means that P. carinii utilizes to obtain its sterols.
    Creator/Author:
    Grant, Tiffany
    Submitter:
    Tiffany Grant
    Date Uploaded:
    04/14/2016
    Date Modified:
    08/09/2016
    License:
    All rights reserved

  • Durres Notebook Team A Vol 2

    Document thumbnail: Durres Notebook Team A Vol 2
    Type:
    Document
    Description/Abstract:
    One half of the field notebook for Team A for the Durrës Regional Archaeological Project (DRAP). Data from this field notebook were entered into the project database. This records the condition of the tracts walked including environmental data, as well as sketches describing the tract and artifact counts.
    Creator/Author:
    Wolpert, Aaron
    Submitter:
    John Wallrodt
    Date Uploaded:
    10/25/2016
    Date Modified:
    12/09/2016
    License:
    Attribution 4.0 International

  • Durres Notebook Team B

    Document thumbnail: Durres Notebook Team B
    Type:
    Document
    Description/Abstract:
    One half of the field notebook for Team B for the Durrës Regional Archaeological Project (DRAP). Data from this field notebook were entered into the project database. This records the condition of the tracts walked including environmental data, as well as sketches describing the tract and artifact counts.
    Creator/Author:
    Acheson, Phoebe E.
    Submitter:
    John Wallrodt
    Date Uploaded:
    10/25/2016
    Date Modified:
    02/06/2017
    License:
    Attribution 4.0 International