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  1. Identifying a Novel Role for the Retrosplenial Cortex in Alzheimer's Disease

    Work
    Type: Image
    Description/Abstract: The Retrosplenial Cortex (RSC) has a persistent role in the establishment of spatial and contextual memory, with also the connections between visuo-spatial association cortices. The RSC’s ability to form afferent and efferent connections with the Parahippocampal areas of the brain allow it to be another prime location in the brains of both rodents and humans where multiple cues are linked together in memory formation, storage and retrieval of Long Term Memories. Due to the high nature of memory formation and retrieval, the RSC has become a section of the brain that in recent years has been more heavily focused on for the research of Alzheimer’s and Dementia. The RSC has not been examined fully in previous studies with examination of the expression of the apolipoprotein E (APOE) gene along with other genetic and regulatory factors. There are 3 major alleles of the APOE gene (APOE2, APOE3, and APOE4), with APOE4 having the greatest risk for AD. In this research, I identify the relative connection between DEK the proto-oncogene and APOE3 and APOE4 in a rodent model, looking specifically at the RSC and how it affects spatial memory with an induced model of chronic stress.
    Creator/Author: Nguyen, Elizabeth T.; Selmanovic, Din; Balmer, Nikolaus J.; Ghisays, Valentina, and Solomon, Matia B.
    Submitter: Din Selmanovic
    Publisher: University of Cincinnati
    Date Uploaded:
    Date Modified: 2018-06-27T18:12:26Z
    Date Created: 2018-04-13
    Rights: Public Domain Mark 1.0
    Genre: Poster
  2. Schafer_Slides_Box_4-2_Slide_338_1300.tif

    W0892b460?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:29Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  3. Schafer_Slides_Box_4-2_Slide_339_1301.tif

    Dv13zt78b?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:28Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  4. Schafer_Slides_Box_4-2_Slide_320_1291.tif

    Vt150j87g?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:27Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  5. Schafer_Slides_Box_4-2_Slide_344_1303.tif

    Qn59q463h?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:27Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  6. Schafer_Slides_Box_4-2_Slide_371_1317.tif

    Xd07gt14f?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:26Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  7. Schafer_Slides_Box_4-2_Slide_352_1307.tif

    765372006?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:25Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  8. Schafer_Slides_Box_4-2_Slide_302_1282.tif

    3484zh47k?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:20Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  9. Schafer_Slides_Box_4-2_Slide_321_1292.tif

    Ms35t9227?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:20Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2
  10. Schafer_Slides_Box_4-2_Slide_359_1311.tif

    C247ds630?file=thumbnail
    Type: Image
    Description/Abstract: Cross section of EM slide from Dr. Schafer, archived by Christy M. Caudill, Res. Assoc.
    Creator/Author: Huston, Ron
    Submitter: Christy Petersen
    Date Uploaded:
    Date Modified: 2018-06-07T21:47:17Z
    Date Created: 2017
    Rights: Open Data Commons Attribution License (ODC-By)
    Note: Box 4 - 2