LS513 cells were treated with a combination of varying concentrations of MRTX1133 with varying concentrations of either afatinib, sapitinib, or pelitinib for 72 hours. Absorbances were normalized to DMSO control for % viability. The attached files were compiled in data format from n=2 data sets (6 data points total for each combination) and uploaded to SynergyFinder+ with % viability chosen as response.
Hearing data obtained using Bone Conduction Auditory Brainstem Response (BC-ABR) testing on six Greater Caribbean Manatees being rehabilitation at the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico. Hearing data was collected while hearing assessments were conducted for clinical assessments of hearing.
Data collected for a project under the Dysphagia Rehabilitation Lab at the University of Cincinnati. The manuscript was submitted to the American Journal of Speech Language Pathology and is currently under review. Below is the abstract.
Purpose: Manometric measures of lingual function are widely used in clinical practice, premised on the assumption that lingual impairments affect oropharyngeal swallowing. This study assessed correlations between measures of lingual function and oropharyngeal swallowing impairments using the Modified Barium Swallow Impairment Profile (MBSImP).
Method: Participants undergoing routine Modified Barium Swallow Studies (MBSS) were recruited if able and willing to complete the lingual measurement protocol. Post-MBSS, participants completed the Eating Assessment Tool (EAT-10) and measures of lingual pressure during a saliva swallow, anterior maximum isometric press (aMIP), effortful swallow, anterior isometric endurance (ISO-M), and anterior isotonic endurance (ISO-T). Correlations between these measures and MBSImP Oral Total (OT) and Pharyngeal Total (PT) Overall Impression scores and Penetration-Aspiration Scale (PAS) scores were evaluated using Spearman’s correlation coefficients.
Results: The final sample included 41 patients (23 men, 18 women; M= 61.75 ± 14.72 years) with heterogenous diagnoses. Analyses showed a moderate, significant negative correlation between aMIP and Oral Total (rs = -0.44, p < .01), and ISO-M and OT (rs = -0.36, p = .02). Specifically, aMIP was strongly correlated with oral residue (Component 5; rs = -0.49, p < .01), and ISO-M with tongue control during bolus hold (Component 2; rs = -0.47, p < .01). No significant correlations were found with Pharyngeal Total, EAT-10 or PAS scores.
Conclusions: Some lingual measurements correlate with oral physiological impairments, suggesting potential utility as clinical indicators of oral swallowing physiology. Further research is needed to explore these relationships across different patient populations.
The dataset includes all the data used to generate figures for the article submitted to the journal of Neuron. This includes individual figure panels and the raw data used to generate each figure panel, as well as the statistical analyses for each experiment.
This is an excel file of the interior design senior theses with student's name, title of project, description of project and date. Physical access to the works can be requested here https://uclid.uc.edu/record=b1239197~S39.
