This document is a workshop workbook for EndNote X8, a citation and reference management software product. The workbook provides descriptions and exercises for most of the major features of EndNote, including program customization, importing & exporting data, organization and management of data, full text recovery & management, cite-while-you-write utility and EndNote Online.
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death ligand 1 (PD-L1) expression on gastric epithelial cells, yet the mechanism is unknown. We hypothesize that H. pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Shh signaling pathway during infection. To identify the role of Shh signaling as a mediator of H. pylori-induced PD-L1 expression, human gastric organoids generated from either induced pluripotent stem cells (HGOs) or tissue (huFGOs) were microinjected with bacteria and treated with Hedgehog/Gli inhibitor GANT61. Gastric epithelial monolayers generated from the huFGOs were also infected with H. pylori and treated with GANT61 to study the role of Hedgehog signaling as a mediator of induced PD-1 expression. A patient-derived organoid/autologous immune cell co-culture system infected with H. pylori and treated with PD-1 inhibitor (PD-1Inh) was developed to study the protective mechanism of PD-L1 in response to bacterial infection. H. pylori significantly increased PD-L1 expression in organoid cultures 48 hours post-infection when compared to uninfected controls. The mechanism was cytotoxic associated gene A (CagA) dependent. This response was blocked by pretreatment with GANT61. Anti-PD-L1 treatment of H. pylori infected huFGOs, co-cultured with autologous patient cytotoxic T lymphocytes and dendritic cells, induced organoid death. H. pylori-induced PD-L1 expression is mediated by the Shh signaling pathway within the gastric epithelium. Cells infected with H. pylori that express PD-L1 may be protected from the immune response, creating premalignant lesions progressing to gastric cancer.
The University of Cincinnati (UC) Libraries' Informationist program and Research & Data Services (RDS) unit provide an extensive program of support for the research community. RDS is a highly-integrated unit of UC Libraries, staffed by informationists in the health sciences, sciences, engineering and social sciences and librarians, specialist staff, and student consultants. Our activities infuse across the institution, including the main campus and the Academic Health Center campus, and we oversee innovative spaces that respond to the particular needs of research communities, including informatics, geospatial analysis and data visualization. Since the fall 2015 CNI presentation on the UC Informationists ("New Roles, New Collaborations: Developing an Informationist Program to Support University Research"), we have greatly expanded our partnerships, services and educational offerings. We are now active in data and statistical consulting, collaborations on bioinformatics education, impactful community engagements (e.g., UC Data Day), and deep partnerships with the UC IT unit on initiatives such as the Data & Computational Science Series. At present, we are pursuing a new and challenging vision to realign our work in order to enable the institution's agendas for data science and innovation. We will discuss our experience with scalable growth and other successes in Research & Data Services and our assessment of a future in data science.
Is jazz serious art music? Is jazz in fact America’s classical music? I contend that much jazz is both. This paper is an exploration of these questions, not a history of jazz, although I will have to recount some historical facts. Rather, it is an examination of this music from two perspectives, seeking a convincing argument for my assertions.
This Poster describes a collaborative research project between the Culley and Tepe labs in the UC Department of Biology and UC Libraries Digital Scholarship Center presented at the 2017 UC Data Day ( https://libapps.libraries.uc.edu/blogs/dataday/past-data-days/). The project explores publication patterns of research involving hotspot areas of biodiversity and if researchers from developing countries which tend to have most of the biodiversity hotspots, are adequately represented as authors in the scientific literature indexed in Scopus (TM-Elsevier), JSTOR, and PubMed.
In this paper, I study how medical records are being used by cyber-criminal for financial gain and patient manipulation. I studied what kind of criminal organizations may be involved in these operations and confirmed incidents from the black market. I conducted a literature review which generated several sources from online databases. I determined five major criminal factions that are most likely to use compromised medical records, determined possible motivations and looked at several cases of medical records being sold on the black market. The healthcare industry’s digitization efforts have left it tremendously ill-equip to combat emerging threats. It is evident that the healthcare industry must take extreme measures in order to counteract the evolving threat landscape. It is my hope that the findings of paper will being to shed light on these issues and help healthcare professionals understand what kind of threats the industry is facing.