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- Type:
- Collection
- Description/Abstract:
- For Jacques Lacan, “psychoanalysis is the discipline which has reestablished the bridge linking modern man to the ancient myths.” This bridge towards myth that inevitably runs through the unconscious lays bare the scaffolding of culture. Famously, for Lacan, the unconscious is structured like a language, operating in one part through chains of signifiers which comprise a register of experience called the Symbolic. This Symbolic order, in relation to its two counterparts the Imaginary and the Real, is anchored by a fundamental signifier, the Symbolic Father, also called the Name-of-the-Father. Not necessarily a literal father, the Name-of-the-Father represents the lawgiving and morally punitive function that confers identity and legitimacy to the subject, in a clinical sense; culturally, it represents the guarantor of the laws, rules, and authority that comprise society. It imposes meaning. If repressed, meaning collapses, and the subject falls back into the Imaginary order, the order of fantasy. Augustus Saint-Gaudens’ towering bronze, 'The Puritan,' first unveiled in Springfield, Massachusetts on Thanksgiving Day in 1887, appears at first to exemplify the Name-of-the-Father as a dramatic consolidation of shared history and moral authority in an age of surfeited civic virtue. This is, however, only smoke and mirrors, a taste of the Lacanian Imaginary. In its embodiment of imagined Puritan virtue, it hides a dissonance between Puritanism, the artist, and an evolving nation struggling to define itself in its Gilded Age. Any meaningful study on The Puritan, particularly one dependent upon historical and social context, is indebted art historian Erika Doss. Her painstaking work in “Augustus Saint-Gaudens’s The Puritan: Founders’ Statues, Indian Wars, Contested Public Spaces, and Anger’s Memory in Springfield, Massachusetts” (2012) is a key interlocutor that provides rather crucial social and cultural contexts surrounding the statue. Where Doss presents a comprehensive socio-political account, this paper approaches The Puritan from a distinctly psychoanalytic perspective, expanding her insights through Lacanian theory. In doing so, I argue that, in the wake of cultural uncertainty following the American Civil War, Saint-Gaudens’ The Puritan (1886) functions as a compensatory and contradictory fantasy of moral authority; as a foreboding yet caricatural paternal archetype, it fails as a Lacanian signifier of the Symbolic Father, exposing the fragility and ultimately the neurosis of Gilded Age myth-making. Upon interrogation of The Puritan in the ideological significance of its patronage, its formal contradictions, and finally, its psychic disfigurement through parody, my paper uncovers how civic art does not simply reflect ideology, it actively constructs and performs it as a symptom of a myth-making society.
- Creator/Author:
- Reisser, Kristopher
- Submitter:
- Kristopher Reisser
- License:
- Public Domain Mark 1.0
- Type:
- Collection
- Description/Abstract:
- Throughout the 15th century, depictions of the Adoration of the Magi began to take new forms. Merchants, pilgrims, and wealthy individuals were all part of a major shift in globalization, and this is reflected through the Adoration of the Magi (c. 1480-85) by the Master of the Legend of Saint Lucy. - Rather than adhering to a strictly European vision, the artist now includes elements which reflect the culmination of trade within 15th century Northern Europe. Although there is knowledge and understanding of the developments within depictions of the Adoration, Saint Lucy’s paintings asserts itself as a direct reflection of shifting ideals and a focus on a secularized vision. Scholars such as Dr. Jean C. Wilson and Dr. Yona Pinson have guided my research thus far, especially in terms of market practices in Bruges. While these scholars provide insightful information concerning free marks, globalization, and changing depictions of the Adoration, there is a lack of connectedness, which is necessary to establish the shift. - Specifically, I am addressing various panel paintings of the Adoration from ca. 1390-1485 to consider the impact of globalization of shifting trends and how this affects the region at large. My research focuses on how depictions of the Adoration vary based on time, place, and potential influences (such as geography, patrons, and use of painting). Adoration of the Magi survives as one of the first major scenes which has such an emphasis on expanding global markets and trade. In conclusion, this project, by closely examining marketplace standards, pilgrimage, shifting ideals of race, and a growing secular attitude to favor patrons, works to shed new light on 15th century adaptations of the Adoration of the Magi.
- Creator/Author:
- Wells, Maiana
- Submitter:
- Maiana Wells
- License:
- All rights reserved
- Type:
- Collection
- Description/Abstract:
- Survey measures and consent documents for Mothers and Fathers in English and Spanish. All measures were translated into Spanish by a native speaker and back translated from Spanish into English in order to ensure language equivalence. Available documents: Father's Survey Packet - English.doc Father's Survey Packet - Mexican American in English.doc Father's Survey Packet - Spanish.doc Mother's Survey Packet - English.doc Mother's Survey Packet - Mexican American in English.doc Mother's Survey Packet - Spanish.doc Online Intro and Consent - English.doc Online Intro and Consent - Spanish.doc Survey Measures include: Acculturation/incorporation – Abbreviated Multidimensional Acculturation Scale (Zea, Asner-Self, Birman, & Buki, 2003). The AMAS-ZABB is a 42 item, self-report scale with Likert-type response options designed to assess three factors associated with acculturation in the United States and in the country of origin: identity, language competence, and cultural competence. Parenting style – The PPQ scale yields three continuous scores reflecting Baumrind’s (1971) three parenting styles of authoritative, authoritarian, and permissive. Parental feeding practices – 49-item questionnaire that measures 12 aspects of parental feeding behavior, including monitoring child food intake, using food to regulate the child’s emotions, using food as a reward, child control over feeding, teaching about nutrition, encouraging good habits, restricting child’s food intake for weight reasons, restricting child’s intake for health reasons, and modeling healthy eating habits. Child eating behaviors – A 35-item parent-report questionnaire that measures eight dimensions of eating style in children. These constructs include responsiveness to food, enjoyment of food, satiety responsiveness, slowness in eating, fussiness, emotional overeating, emotional undereating, and desire for drinks. Anti-fat attitudes – Crandall’s Anti-fat Attitudes Questionnaire (AFA; Crandall, 1994) will assess parents’ attitudes toward obesity. This measure consists of 13 Likert-type response items and includes three subscales: the evaluation and dislike of individuals who are fat, the controllability of weight/fat, and personal concerns and distress about weight or the prospect of becoming overweight. Parent’s concern about child overweight - Concern for child’s overweight and child’s underweight were measured by ten questions from two subscales derived from the Child Feeding Questionnaire. Perception of child’s body. Parents’ satisfaction with their child’s current body shape was assessed utilizing body silhouettes of children (Collins, 1991; Appendix F). Parents were asked to indicate which of the seven figures they feel most closely resembles their child and then rate the figure they would most like their child to resemble and the figure they would not like their child to resemble.
- Creator/Author:
- Oehlhof, Marissa
- Submitter:
- Marissa Oehlhof, PhD
- License:
- Attribution-NonCommercial-ShareAlike 4.0 International
- Type:
- Collection
- Description/Abstract:
- Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide, with roughly 41% of CRC cases harboring a KRAS mutation. There have been significant advances with the advent of KRAS-targeted therapies; however, acquired resistance to KRAS-targeted treatments has occurred in other cancers, with mechanisms including increased HER family expression among other receptor tyrosine kinases. HER3, a member of the HER family that is kinase impaired, has been shown to be a resistance mechanism upon inhibition of the HER family and downstream targets including RAS/MEK/ERK and PI3K/AKT. Our study examines whether HER3 and mutant KRAS are viable co-targets. We find that KRAS mutations tend to co-occur with HER3 alterations in a large panel of cancers and in CRCs. Our results show that both total and activated HER3 levels increase in CRC patient derived organoids and cell lines after treatment with KRASG12D targeted agents, indicating that HER3 could be a potential adaptive response mechanism to KRAS-targeted therapy. Further, we found that genetic knock-down of KRAS and HER3 resulted in a statistically significant reduction in growth of CRC cells compared to single knockdown of either KRAS or HER3. We observed that kinase impaired HER3 binding partners, as assessed by immunoprecipitation, is cell dependent with EGFR binding HER3 in one cell line. After co-treating CRC cells with pan-HER inhibitors in combination with MRTX1133, a KRASG12D inhibitor, synergistic and additive effects in reduction in cell growth were observed in a drug-dependent manner. Finally, we found that co-targeting KRASG12D mutant cells with a KRASG12D inhibitor and a HER3 antibody-drug conjugate further reduced cell viability. We posit that co-targeting both KRASG12D and HER3, whether directly or indirectly, is a potential therapeutic strategy in CRC patients.
- Creator/Author:
- Garrett, Joan and Kilroy, Mary Kate
- Submitter:
- Joan Garrett
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Moore, Amanda
- Submitter:
- Amanda Moore
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- The Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) rating method was developed in head and neck cancer populations to describe severity of aspiration and residue. The purpose of this study was to assess criterion validity of DIGEST in a post-stroke cohort. In this retrospective analysis, 2 raters (using version 2 criteria) performed DIGEST rating on recordings of modified barium swallow studies (MBSS) from 88 post-stroke patients that were extracted from a larger de-identified database. Modified Barium Swallow Study Impairment Profile (MBSImP) scores and Functional Oral Intake Scale (FOIS) scores were used to determine criterion validity. Inter-rater and intra-rater reliability for overall DIGEST grade were substantial (ƙ=0.69 and 0.73, respectively), however inter-rater reliability for efficiency were only moderately reliable (ƙ=0.52). Reliability for MBSImP scoring was excellent for Pharyngeal Total (PT) scores (ICC=0.81-0.93). Overall DIGEST grades were significantly associated with PT scores in the expected direction (τ=0.51, p<0.0001), and there was no association between Oral Total (OT) and DIGEST grade (τ=-0.02, p=0.077). Pairwise comparisons using PT scores indicated significant differentiation between DIGEST grades 0 from all other grades (p<0.0001), with overlap in intermediate grades (p=0.106-0.713). Functional Oral Intake Scale (FOIS) scores were significantly associated with DIGEST grade in the anticipated direction (τ=-0.43, p<0.0001). Expected psychometrics and acceptable reliability for DIGEST grading were shown in this post-stroke cohort. A larger dataset would clarify mid-grade differentiation and potential influence of oral phase impairments in this sub-population.
- Creator/Author:
- Krekeler, Brittany
- Submitter:
- Brittany Krekeler
- License:
- Open Data Commons Public Domain Dedication and License (PDDL)
- Type:
- Collection
- Description/Abstract:
- Rohit Mandalapu's Research Papers
- Creator/Author:
- Mandalapu, Rohit
- Submitter:
- Rohit Mandalapu
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- Data associated withs studies carried out in the Biomedical Ultrasonics and Cavitation Laboratory (PI: Haworth) associated with NIH grant R01HL148451. These studies focus on the development of a perfluorocarbon emulsion for use in ultrasound-mediated oxygen scavenging. The studies also assess the risk of gas embolization using a Langendorff preparation for a rat work heart model.
- Creator/Author:
- Haworth, Kevin and Al Rifai, Nour
- Submitter:
- Kevin Haworth
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- Data from a project studying Cincinnati's gas streetlights. Table S1 contains latitude and longitude information for all natural gas streetlights identified within the Cincinnati city limits. These data can also be viewed at https://www.google.com/maps/d/edit?mid=1oEm033LLFl0KN3wIYVYyjkjUUCmxsF0&usp=sharing Table S2 contains methane emission rates measured from a subset of natural gas streetlights in Cincinnati. Measurements were made by Dr. Amy Townsend-Small and her students.
- Creator/Author:
- Townsend-Small, Amy
- Submitter:
- Amy Townsend-Small
- License:
- Public Domain Mark 1.0
- Type:
- Collection
- Description/Abstract:
- This is a digitized collection of slides that were presented by Walter E. Langsam on the Cincinnati architecture firm Desjardins and Hayward
- Creator/Author:
- Meyer, Elizabeth A. and Langsam, Walter E.
- Submitter:
- Elizabeth A. Meyer
- License:
- All rights reserved