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1. Test
- Type:
- Article
- Description/Abstract:
- etset
- Creator/Author:
- Scherz, Thomas
- Submitter:
- Thomas Scherz
- Date Uploaded:
- 03/21/2025
- Date Modified:
- 03/21/2025
- License:
- Attribution-ShareAlike 4.0 International
- Type:
- Document
- Description/Abstract:
- Have you wanted to pursue your own research in Library and Information Science (LIS) but are unsure of how to start? You aren’t alone - the lack of affordable, accessible, and effective training opportunities means many library workers do not have the resources, time, or support to learn how to do research effectively, which leads to a field that lacks diverse, inclusive, and robust scholarship. Utilizing funds granted by the Institute of Museum and Library Sciences, the presenters of this session have created a free, sustainable curriculum that provides library workers with the foundational knowledge and specialized skills necessary to conduct and publish rigorous original research in an effort toward improving LIS literature and promoting lifelong learning. This curriculum centers reflection and encourages learners to use their own lived experiences to inform their research journey, while also offering vital information that serves to democratize the often-privileged information around research and publishing for the public good. This presentation will serve as the official launch of LibParlor Online Learning: An Open Source Curriculum for LIS Researchers, and will share preliminary pilot participant data to demonstrate how the curriculum has resonated with learners. Attendees interested in LIS research will learn how this curriculum could be of use to their own professional development as well as others in the field. Attendees will also be able to evaluate the curriculum and receive support from the presenters on how to embed this program into their own library organizations to support a robust culture of research.
- Creator/Author:
- Fargo, Hailley; Powell, Charissa; Heinbach, Chelsea, and Bhat, Nimisha
- Submitter:
- Nimisha Bhat
- Date Uploaded:
- 03/19/2025
- Date Modified:
- 03/19/2025
- License:
- Attribution 4.0 International
- Type:
- Document
- Description/Abstract:
- This presentation provides an overview of LibParlor Online Learning, a free, open-source online curriculum of learning modules, and share how this professional development program will build the capacity for academic Library and Information Science (LIS) professionals to conduct and publish rigorous original research. The lack of affordable, accessible, and effective training opportunities means many librarians do not have the resources, time, or support to learn how to do research, and this leads to a field that lacks diverse, inclusive, and robust scholarship. The presenters have created grant funded open-source online curriculum that will provide LIS professionals with the foundational knowledge and specialized skills necessary to conduct and publish rigorous original research. This work will democratize the often privileged information around research and publishing in an effort toward diversifying and improving LIS literature.
- Creator/Author:
- Bhat, Nimisha; Fargo, Hailley; Heinbach, Chelsea, and Powell, Charissa
- Submitter:
- Nimisha Bhat
- Date Uploaded:
- 03/19/2025
- Date Modified:
- 03/19/2025
- Date Created:
- 2023
- License:
- Attribution 4.0 International
- Type:
- Image
- Description/Abstract:
- The Librarian Parlor (aka LibParlor or #LibParlor) is an online space ( https://libparlor.com) for conversing, sharing expertise, and asking questions about the process of pursuing, developing, and publishing library research. LibParlor provides a community for new-to-research library workers as they consider a research agenda and provide support as they may face a number of challenges. LibParlor aims to address these challenges in part by collecting and showcasing honest reflections, conversations, and how-tos from library professionals engaged in library research. In providing this space, LibParlor aims to spark conversation and cultivate a community of researchers. This poster presents the mission and vision of LibParlor, how we got started, some of the work we’ve done, and plans for the future. We share what we have learned through the formation of an online community, including the importance of having established workflows, detailed editorial policies, and clear communication between members of the team as well as writers. This poster shares our lessons learned and takeaways for others wanting to start a new group. For example, early on we spent a considerable amount of time developing internal and external workflow documents. However, now our processes are documented and clear for contributors. We would also provide recommendations for getting buy-in from major stakeholders before starting a project like this.
- Creator/Author:
- Powell, Charissa; Fargo, Hailley; Bhat, Nimisha, and Heinbach, Chelsea
- Submitter:
- Nimisha Bhat
- Date Uploaded:
- 03/19/2025
- Date Modified:
- 03/19/2025
- Date Created:
- 2018
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- SNU-407 cells were treated with a combination of varying concentrations of MRTX1133 with varying concentrations of either afatinib, sapitinib, or pelitinib for 72 hours. Absorbances were normalized to DMSO control for % viability. The attached files were compiled in data format from n=2 data sets (6 data points total for each combination) and uploaded to SynergyFinder+ with % viability chosen as response.
- Creator/Author:
- Kilroy, Mary
- Submitter:
- Mary Kilroy
- Date Uploaded:
- 03/07/2025
- Date Modified:
- 03/07/2025
- Date Created:
- 2024
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- LS513 cells were treated with a combination of varying concentrations of MRTX1133 with varying concentrations of either afatinib, sapitinib, or pelitinib for 72 hours. Absorbances were normalized to DMSO control for % viability. The attached files were compiled in data format from n=2 data sets (6 data points total for each combination) and uploaded to SynergyFinder+ with % viability chosen as response.
- Creator/Author:
- Kilroy, Mary
- Submitter:
- Mary Kilroy
- Date Uploaded:
- 03/07/2025
- Date Modified:
- 03/07/2025
- Date Created:
- 2024
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide, with roughly 41% of CRC cases harboring a KRAS mutation. There have been significant advances with the advent of KRAS-targeted therapies; however, acquired resistance to KRAS-targeted treatments has occurred in other cancers, with mechanisms including increased HER family expression among other receptor tyrosine kinases. HER3, a member of the HER family that is kinase impaired, has been shown to be a resistance mechanism upon inhibition of the HER family and downstream targets including RAS/MEK/ERK and PI3K/AKT. Our study examines whether HER3 and mutant KRAS are viable co-targets. We find that KRAS mutations tend to co-occur with HER3 alterations in a large panel of cancers and in CRCs. Our results show that both total and activated HER3 levels increase in CRC patient derived organoids and cell lines after treatment with KRASG12D targeted agents, indicating that HER3 could be a potential adaptive response mechanism to KRAS-targeted therapy. Further, we found that genetic knock-down of KRAS and HER3 resulted in a statistically significant reduction in growth of CRC cells compared to single knockdown of either KRAS or HER3. We observed that kinase impaired HER3 binding partners, as assessed by immunoprecipitation, is cell dependent with EGFR binding HER3 in one cell line. After co-treating CRC cells with pan-HER inhibitors in combination with MRTX1133, a KRASG12D inhibitor, synergistic and additive effects in reduction in cell growth were observed in a drug-dependent manner. Finally, we found that co-targeting KRASG12D mutant cells with a KRASG12D inhibitor and a HER3 antibody-drug conjugate further reduced cell viability. We posit that co-targeting both KRASG12D and HER3, whether directly or indirectly, is a potential therapeutic strategy in CRC patients.
- Creator/Author:
- Garrett, Joan and Kilroy, Mary Kate
- Submitter:
- Joan Garrett
- License:
- Attribution 4.0 International
8. Test File
- Type:
- Document
- Description/Abstract:
- Test Document
- Creator/Author:
- Famulari, Stevie
- Submitter:
- Stevie Famulari
- Date Uploaded:
- 03/05/2025
- Date Modified:
- 03/05/2025
- Date Created:
- March 3, 2025
- License:
- Public Domain Mark 1.0
- Type:
- Dataset
- Description/Abstract:
- Hearing data obtained using Bone Conduction Auditory Brainstem Response (BC-ABR) testing on six Greater Caribbean Manatees being rehabilitation at the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico. Hearing data was collected while hearing assessments were conducted for clinical assessments of hearing.
- Creator/Author:
- Daniel Gonzalez-Socoloske; Moore, Amanda; Scheifele, Peter, and Antonio A. Mignucci-Giannoni
- Submitter:
- Amanda Moore
- Date Uploaded:
- 02/21/2025
- Date Modified:
- 02/21/2025
- Date Created:
- 2024-05-28
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Daniel Gonzalez-Socoloske; Scheifele, Peter; Antonio A. Mignucci-Giannoni, and Moore, Amanda
- Submitter:
- Amanda Moore
- Date Uploaded:
- 02/21/2025
- Date Modified:
- 02/21/2025
- Date Created:
- 2024-05-29
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Moore, Amanda; Antonio A. Mignucci-Giannoni; Daniel Gonzalez-Socoloske, and Scheifele, Peter
- Submitter:
- Amanda Moore
- Date Uploaded:
- 02/21/2025
- Date Modified:
- 02/21/2025
- Date Created:
- 2024-05-24
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Scheifele, Peter; Daniel Gonzalez-Socoloske; Antonio A. Mignucci-Giannoni, and Moore, Amanda
- Submitter:
- Amanda Moore
- Date Uploaded:
- 02/21/2025
- Date Modified:
- 02/21/2025
- Date Created:
- 2024-05-24
- License:
- Attribution 4.0 International
- Type:
- Collection
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Moore, Amanda
- Submitter:
- Amanda Moore
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- Greater Caribbean manatee (Trichechus manatus manatus) pool recordings from the Caribbean Manatee Conservation Center in Bayamon, Puerto Rico including location and depth of recordings as well as recordings from the natural protected habitat of Laguna del Condado, San Juan, Puerto Rico which includes the GPS coordinates in the recording title. All recordings obtained using omnidirectional hydrophones with H1 recorder (Model SQ26-H1; Cetacean Research Technology, 2007) and are in .wav format.
- Creator/Author:
- Peter M. Scheifele; Antonio A. Mignucci-Giannoni; Daniel Gonzalez-Socoloske, and Moore, Amanda
- Submitter:
- Amanda Moore
- Date Uploaded:
- 02/21/2025
- Date Modified:
- 02/21/2025
- Date Created:
- 2024-05-24
- License:
- Attribution 4.0 International
- Type:
- Dataset
- Description/Abstract:
- Data collected for a project under the Dysphagia Rehabilitation Lab at the University of Cincinnati. The manuscript was submitted to the American Journal of Speech Language Pathology and is currently under review. Below is the abstract. Purpose: Manometric measures of lingual function are widely used in clinical practice, premised on the assumption that lingual impairments affect oropharyngeal swallowing. This study assessed correlations between measures of lingual function and oropharyngeal swallowing impairments using the Modified Barium Swallow Impairment Profile (MBSImP). Method: Participants undergoing routine Modified Barium Swallow Studies (MBSS) were recruited if able and willing to complete the lingual measurement protocol. Post-MBSS, participants completed the Eating Assessment Tool (EAT-10) and measures of lingual pressure during a saliva swallow, anterior maximum isometric press (aMIP), effortful swallow, anterior isometric endurance (ISO-M), and anterior isotonic endurance (ISO-T). Correlations between these measures and MBSImP Oral Total (OT) and Pharyngeal Total (PT) Overall Impression scores and Penetration-Aspiration Scale (PAS) scores were evaluated using Spearman’s correlation coefficients. Results: The final sample included 41 patients (23 men, 18 women; M= 61.75 ± 14.72 years) with heterogenous diagnoses. Analyses showed a moderate, significant negative correlation between aMIP and Oral Total (rs = -0.44, p < .01), and ISO-M and OT (rs = -0.36, p = .02). Specifically, aMIP was strongly correlated with oral residue (Component 5; rs = -0.49, p < .01), and ISO-M with tongue control during bolus hold (Component 2; rs = -0.47, p < .01). No significant correlations were found with Pharyngeal Total, EAT-10 or PAS scores. Conclusions: Some lingual measurements correlate with oral physiological impairments, suggesting potential utility as clinical indicators of oral swallowing physiology. Further research is needed to explore these relationships across different patient populations.
- Creator/Author:
- Mira, Amna
- Submitter:
- Amna Mira
- Date Uploaded:
- 02/05/2025
- Date Modified:
- 02/05/2025
- License:
- Open Data Commons Public Domain Dedication and License (PDDL)
- Type:
- Dataset
- Description/Abstract:
- Raw data
- Creator/Author:
- Krekeler, Brittany
- Submitter:
- Brittany Krekeler
- Date Uploaded:
- 01/30/2025
- Date Modified:
- 01/30/2025
- Date Created:
- 2025-01-30
- License:
- Open Data Commons Public Domain Dedication and License (PDDL)
- Type:
- Collection
- Description/Abstract:
- The Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) rating method was developed in head and neck cancer populations to describe severity of aspiration and residue. The purpose of this study was to assess criterion validity of DIGEST in a post-stroke cohort. In this retrospective analysis, 2 raters (using version 2 criteria) performed DIGEST rating on recordings of modified barium swallow studies (MBSS) from 88 post-stroke patients that were extracted from a larger de-identified database. Modified Barium Swallow Study Impairment Profile (MBSImP) scores and Functional Oral Intake Scale (FOIS) scores were used to determine criterion validity. Inter-rater and intra-rater reliability for overall DIGEST grade were substantial (ƙ=0.69 and 0.73, respectively), however inter-rater reliability for efficiency were only moderately reliable (ƙ=0.52). Reliability for MBSImP scoring was excellent for Pharyngeal Total (PT) scores (ICC=0.81-0.93). Overall DIGEST grades were significantly associated with PT scores in the expected direction (τ=0.51, p<0.0001), and there was no association between Oral Total (OT) and DIGEST grade (τ=-0.02, p=0.077). Pairwise comparisons using PT scores indicated significant differentiation between DIGEST grades 0 from all other grades (p<0.0001), with overlap in intermediate grades (p=0.106-0.713). Functional Oral Intake Scale (FOIS) scores were significantly associated with DIGEST grade in the anticipated direction (τ=-0.43, p<0.0001). Expected psychometrics and acceptable reliability for DIGEST grading were shown in this post-stroke cohort. A larger dataset would clarify mid-grade differentiation and potential influence of oral phase impairments in this sub-population.
- Creator/Author:
- Krekeler, Brittany
- Submitter:
- Brittany Krekeler
- License:
- Open Data Commons Public Domain Dedication and License (PDDL)
- Type:
- Generic Work
- Description/Abstract:
- Replication Package of "Exploiting Vision-Language Models in GUI Reuse", a paper published in the 22nd International Conference on Systems and Software Reuse (ICSR), Ottawa, Canada, April 27 2025. The authors are: Victoria Niu, Walaa Alshammari, Naga Mamata Iluru, Padmaja Vaishnavi Teeleti, Nan Niu, Tanmay Bhowmik, and Jianzhang Zhang.
- Creator/Author:
- Niu, Nan
- Submitter:
- Nan Niu
- Date Uploaded:
- 01/29/2025
- Date Modified:
- 01/29/2025
- License:
- Open Data Commons Open Database License (ODbL)
- Type:
- Dataset
- Description/Abstract:
- The dataset includes all the data used to generate figures for the article submitted to the journal of Neuron. This includes individual figure panels and the raw data used to generate each figure panel, as well as the statistical analyses for each experiment.
- Creator/Author:
- Zhang, Jun-Ming
- Submitter:
- Jun-Ming Zhang
- Date Uploaded:
- 01/28/2025
- Date Modified:
- 02/26/2025
- Date Created:
- 2022-2025
- License:
- All rights reserved
- Type:
- Collection
- Description/Abstract:
- Rohit Mandalapu's Research Papers
- Creator/Author:
- Mandalapu, Rohit
- Submitter:
- Rohit Mandalapu
- License:
- Attribution 4.0 International