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- Type:
- Student Work
- 摘抄:
- This poster was presented by Dalya Aljanabi at the Undergraduate Scholarly Showcase, University of Cincinnati, Cincinnati, Ohio on April 24, 2026. The abstract is located below. Abstract Cancer recurrence remains a major challenge in oncology due to the persistence of cancer stem cells (CSCs). CSC presents a small but highly aggressive subpopulation of tumor cells characterized by their self-renewal ability, resistance to therapy, and their ability to initiate new tumor growth. Because of these properties, CSCs are one of the main targets for the development of more effective treatment and efficient management of cancer. Recent studies by others suggest that certain antibiotics can selectively inhibit CSC activity. Through our collaboration with the Tiny Earth antibiotic discovery network, antibiotic containing media supernatants produced by soil bacteria were obtained. We screened these supernatants for their ability to destroy lung CSCs using lung CSC-derived tumorspheres. A tumorsphere is a spherical formation generated from the proliferation of one cancer stem cell. During our recent studies, CSC activity was evaluated using tumorsphere assays using (A549) lung cancer cells. Pre-formed A549 lung CSC tumorspheres were treated with antibiotic containing bacterial media supernatants for five days. A549 lung CSC tumorsphere viability was tested using a 3D-Glo luminescence assay. We found that supernatant 19 demonstrated strong suppression of A549 lung CSC tumorsphere viability while additional supernatants showed moderate inhibitory activity. These findings indicate that soil-derived antibiotics can effectively target lung CSC populations. This research supports continued investigation into bacterial derived compounds as potential CSC targeted treatment and establishes a comparative CSC screening framework. This CSC screening framework lays out the foundation for identifying microbial derived compounds capable of targeting CSCs across multiple non-small cell lung cancer models including NCI H460 derived CSC tumorspheres which represents a more aggressive lung carcinoma.
- 作者:
- Shirokawa, Jill; Gomez-Stallons, Vicky; Aljanabi, Dalya, and Girard, Anne-Lise
- 提交者:
- Jill Shirokawa
- 上传日期:
- 10/01/2026
- 更改日期:
- 10/01/2026
- 创建:
- 2026-04-22
- 证书:
- Attribution 4.0 International
-
- Type:
- Article
- 摘抄:
- Non-small cell lung cancer is one of the most prevalent types of cancer that is responsible for the majority of cancer-related deaths worldwide. Recurrence and metastasis continue as a major barriers to the successful treatment of non-small cell lung cancer. Cancer stem cells are a main contributor to cancer recurrence and metastasis thus, a target for lung anticancer therapy. Evidence that some antibiotics are effective cancer stem cell inhibitors makes the identification of new antibiotic cancer stem cell inhibitors a key area in lung anticancer drug discovery. Previously we isolated antibiotic producing bacteria as a part of the Tiny Earth® network and screened their media supernatants for the ability to inhibit cancer stem cells using a tumorsphere assay. One supernatant inhibited breast, prostate, and lung cancer stem cells. In the present study, we find that this antibiotic active supernatant selectively inhibits A549 lung cancer stem cells over bulk A549 lung cancer cells.
- 作者:
- Shirokawa, Jill M.; Girard, Anne-Lise; Patel, Yatra, and Maiorano, John N.
- 提交者:
- Jill Shirokawa
- 上传日期:
- 10/01/2026
- 更改日期:
- 10/02/2026
- 创建:
- 2025-09-24
- 证书:
- Attribution 4.0 International
-
- Type:
- Media
- 摘抄:
- Can magnets repel hurricanes? Well, no... but maybe new magnet technology could play a role in helping prevent future hurricanes. Jett Barham, a 4th year materials engineering undergraduate at the University of Kentucky explores motivations behind research into rare-earth free magnets while sharing his experience as a part of the 2026 REALIZE program at UC.
- 作者:
- Barham, Jett; Mayer, Corrie M.; Steiner, Matthew A., and Payton, Eric J.
- 提交者:
- Eric Payton
- 上传日期:
- 08/15/2026
- 更改日期:
- 08/15/2026
- 创建:
- 2026-07-21
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Media
- 摘抄:
- Rare earth elements. They are a hot topic in the news... but why? What technologies are they used in? Jett Barham, a materials engineering major at University of Kentucky, describes his summer doing research at University of Cincinnati and how new magnet research could shape the global energy landscape.
- 作者:
- Barham, Jett; Steiner, Matthew A., and Payton, Eric J.
- 提交者:
- Eric Payton
- 上传日期:
- 08/13/2026
- 更改日期:
- 08/15/2026
- 创建:
- 2026-08-13
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Dataset
- 摘抄:
- Data of summer monarch righting response to the magnetic field with exposure to thermal regimes.
- 作者:
- Matter, Stephen and Shively-Moore, Samuel
- 提交者:
- Samuel Shively-Moore
- 上传日期:
- 08/08/2026
- 更改日期:
- 08/08/2026
- 创建:
- 2025-09-01
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Article
- 摘抄:
- Major depressive episode (MDE) among adolescents is a significant public health issue. Approximately, 4.5 million adolescents have experienced an MDE in the past year. This study examined whether MDEs among adolescents differed based on specific parenting behaviors. A national sample of adolescents ages 12 to 17 years (n = 11,572) completed the 2023 National Survey of Drug use and Health. Univariate and multivariable logistic regression analyses were conducted to determine whether lifetime and past year MDE differed based on parenting behaviors. Results indicated that adolescents at highest risk for both lifetime and past-year MDE were female, older (14-15 or 16-17-years-old), and white. Regarding parenting behaviors, adolescents at highest risk for lifetime and past-year MDE were those who had parents never/seldom check their homework, never/seldom help with their homework, never/seldom limit the amount of TV, never/seldom tell them they did a good job, never/seldom tell them they were proud of them, and who argued/fought with them ten or more times in the past year. These findings show the intricate relationship between adolescent MDE and parenting behaviors. Public health educators should encourage parents to engage in authoritative parenting behaviors (defined as high levels of parental support, warmth, and clear expectations) to help prevent MDE among adolescents. Findings should be used to assist program developers in incorporating parenting components in MDE prevention and treatment efforts.
- 作者:
- Mahabub, Md Saif; Vidourek, Rebecca A.; Merianos, Ashley L., and King, Keith A.
- 提交者:
- Md Saif Mahabub
- 上传日期:
- 08/06/2026
- 更改日期:
- 08/06/2026
- 创建:
- 2025-10
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Image
- 摘抄:
- This research analyzes the "syndemic" of mental stress and physical pain among 299 unregulated laborers in Dhaka, Bangladesh. Results reveal that psychological distress increased the risk of physical injury by 28-fold, highlighting a critical link between economic instability and worker health. These findings offer urgent parallels to the U.S. "gig economy," where delivery and warehouse workers face similar occupational injustices without safety nets. The presentation moves beyond ergonomics to propose a Social Justice Framework, challenging attendees to advocate for ethical supply chains and for mental health protections for vulnerable workers, both globally and locally.
- 作者:
- Mahabub, Md Saif
- 提交者:
- Md Saif Mahabub
- 上传日期:
- 08/02/2026
- 更改日期:
- 08/02/2026
- 创建:
- 2026-02-20
- 证书:
- Attribution 4.0 International
-
- Type:
- Media
- 摘抄:
- What happens when the biggest barrier to scientific discovery isn’t a lack of ideas, but the cost of the tools themselves? In this episode, Jarin Earle, a junior in Mechanical Engineering at North Carolina A & T State University, shares how a summer research project designing a low-cost viscometer changed the way he thinks about engineering; not as a way to build machines, but as a way to expand who gets the opportunity to do science.
- 作者:
- Earle, Jarin O.; Yavitt, Benjamin M., and Payton, Eric J.
- 提交者:
- Eric Payton
- 上传日期:
- 07/24/2026
- 更改日期:
- 08/15/2026
- 创建:
- 2026-07-24
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Media
- 摘抄:
- Through my college journey, the terms “research” and “zero-emissions” have become central to my academic identity. Not just because they reflect both my lab experience and keen interest in sustainable tech, but because they evoke a personal question that many high school seniors and college underclassmen grapple with: what does it mean to be a scientist? I’m Trevon Collins, a mechanical engineering student at Tennessee Technological University. In this podcast episode, I’ll share the answers I’ve found through investigating age-old secrets of phase change and their implications for the green transition.
- 作者:
- Collins, Trevon L; Yasin, Ayaaz; Bellur, Kishan, and Payton, Eric J
- 提交者:
- Eric Payton
- 上传日期:
- 07/24/2026
- 更改日期:
- 07/25/2026
- 创建:
- 2026-07-24
- 证书:
- Attribution-NonCommercial 4.0 International
-
- Type:
- Media
- 摘抄:
- Kennedy Whiters lives by "Do not fear failure; rather, fear not trying." She participated in the REALIZE REU when she was a junior at Albany State University. Kennedy performed research on methanogens, a type of anaerobic bacteria that consumes carbon dioxide and turns it into natural gas, which we can use as a source of energy in power plants. In this episode, she describes her experience working in the lab of Prof Annie Rowe, where she found the lab group to be a good source of positive support, like her family.
- 作者:
- Whiters, Kennedy D.; Rowe, Annette R., and Payton, Eric J.
- 提交者:
- Eric Payton
- 上传日期:
- 07/19/2026
- 更改日期:
- 07/24/2026
- 创建:
- 2024-07-28
- 证书:
- Attribution-NonCommercial 4.0 International