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  • Supplementary materials for "Sympathetic Controls Fate and Function of Adult Sensory Neurons"

    Dataset thumbnail: Supplementary materials for "Sympathetic Controls Fate and Function of Adult Sensory Neurons"
    Type:
    Dataset
    Description/Abstract:
    This file includes: Figs. S1 to S3, Tables S1 to S2.
    Creator/Author:
    Zhang, Jun-Ming
    Submitter:
    Jun-Ming Zhang
    Date Uploaded:
    02/12/2026
    Date Modified:
    02/12/2026
    Date Created:
    2022-2026
    License:
    All rights reserved

  • Lingual-Swallowing Functions Raw Data

    Dataset thumbnail: Lingual-Swallowing Functions Raw Data
    Type:
    Dataset
    Description/Abstract:
    Data collected for a project under the Dysphagia Rehabilitation Lab at the University of Cincinnati. The manuscript was submitted to the American Journal of Speech Language Pathology and is currently under review. Below is the abstract. Purpose: Manometric measures of lingual function are widely used in clinical practice, premised on the assumption that lingual impairments affect oropharyngeal swallowing. This study assessed correlations between measures of lingual function and oropharyngeal swallowing impairments using the Modified Barium Swallow Impairment Profile (MBSImP). Method: Participants undergoing routine Modified Barium Swallow Studies (MBSS) were recruited if able and willing to complete the lingual measurement protocol. Post-MBSS, participants completed the Eating Assessment Tool (EAT-10) and measures of lingual pressure during a saliva swallow, anterior maximum isometric press (aMIP), effortful swallow, anterior isometric endurance (ISO-M), and anterior isotonic endurance (ISO-T). Correlations between these measures and MBSImP Oral Total (OT) and Pharyngeal Total (PT) Overall Impression scores and Penetration-Aspiration Scale (PAS) scores were evaluated using Spearman’s correlation coefficients. Results: The final sample included 41 patients (23 men, 18 women; M= 61.75 ± 14.72 years) with heterogenous diagnoses. Analyses showed a moderate, significant negative correlation between aMIP and Oral Total (rs = -0.44, p < .01), and ISO-M and OT (rs = -0.36, p = .02). Specifically, aMIP was strongly correlated with oral residue (Component 5; rs = -0.49, p < .01), and ISO-M with tongue control during bolus hold (Component 2; rs = -0.47, p < .01). No significant correlations were found with Pharyngeal Total, EAT-10 or PAS scores. Conclusions: Some lingual measurements correlate with oral physiological impairments, suggesting potential utility as clinical indicators of oral swallowing physiology. Further research is needed to explore these relationships across different patient populations.
    Creator/Author:
    Mira, Amna
    Submitter:
    Amna Mira
    Date Uploaded:
    02/05/2025
    Date Modified:
    02/05/2025
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)

  • DIGEST Stroke Validation

    Dataset thumbnail: DIGEST Stroke Validation
    Type:
    Dataset
    Description/Abstract:
    Raw data
    Creator/Author:
    Krekeler, Brittany
    Submitter:
    Brittany Krekeler
    Date Uploaded:
    01/30/2025
    Date Modified:
    01/30/2025
    Date Created:
    2025-01-30
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)

  • Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic neuropathic pain

    Dataset thumbnail: Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic neuropathic pain
    Type:
    Dataset
    Description/Abstract:
    The dataset includes all the data used to generate figures for the article submitted to the journal of Neuron. This includes individual figure panels and the raw data used to generate each figure panel, as well as the statistical analyses for each experiment.
    Creator/Author:
    Zhang, Jun-Ming
    Submitter:
    Jun-Ming Zhang
    Date Uploaded:
    01/28/2025
    Date Modified:
    02/26/2025
    Date Created:
    2022-2025
    License:
    All rights reserved

  • Tongueometer Validation Data

    Dataset thumbnail: Tongueometer Validation Data
    Type:
    Dataset
    Description/Abstract:
    ABSTRACT Purpose: Tongue manometry (i.e. tongue pressure measurement) is a commonly used assessment for patients with suspected oral-motor involvement in swallowing disorders. Availability of lingual manometry has changed in recent years, with the introduction of the TongueometerTM device being a more affordable tongue manometry system. The purpose of this study was to test concurrent (criterion) validity of the TongueometerTM compared to the current standard reference device, the Iowa Oral Performance Instrument, IOPI®. Method: Adults without dysphagia were recruited for participation in this study. Standard lingual measurements (swallowing-related pressures, maximum isometric pressure (MIP), and maximum isometric endurance) were recorded, with the bulb anteriorly placed, with both devices, in a randomized order. The Bland-Altman method was used to determine concurrent (criterion) validity of these measurements compared to the clinical standard IOPI® device. A recently available suggested corrective value by Curtis and colleagues (2023) was also applied, with comparisons made between devices both with and without the Curtis correction. Results: The final sample included 70 adult participants aged 20-89 years (average age 52.3 years). Measures with the TongueometerTM device were significantly lower when compared with the same measures taken using the IOPI® (p<0.01) for all measures including MIP, endurance, and swallow pressures. The correction suggested by Curtis and colleagues did not ameliorate these differences. Conclusions: The TongueometerTM lingual measurements were consistently lower compared to the IOPI®. Clinical use of values taken with the TongueometerTM device should be compared to normative data published for each specific device. Available features of each device (e.g. display, bulb texture, technology/application) should be considered when selecting which device to use with an individual patient. 
    Creator/Author:
    Krekeler, Brittany
    Submitter:
    Brittany Krekeler
    Date Uploaded:
    01/26/2024
    Date Modified:
    01/26/2024
    Date Created:
    2020-01-01
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)

  • Retrospective Chart Review:Efficacy of methylprednisolone vs. triamcinolone used in lumbar epidural steroid injections

    Dataset thumbnail: Retrospective Chart Review:Efficacy of methylprednisolone vs. triamcinolone used in lumbar epidural steroid injections
    Type:
    Dataset
    Description/Abstract:
    Retrospective chart review project of subjects receiving lumbar epidural steroid injections for low back pain associated with degenerative disc disease. The primary objective was to compare the efficacy of two different steroids used during the time period studied, methylprednisolone and triamcinolone.
    Creator/Author:
    Strong, Judith
    Submitter:
    Judith Strong
    Date Uploaded:
    08/24/2023
    Date Modified:
    08/15/2024
    Date Created:
    2023-08
    License:
    Open Data Commons Public Domain Dedication and License (PDDL)

  • Employing Strategies to Address Implicit Racial Bias in the Home Visit Setting

    Dataset thumbnail: Employing Strategies to Address Implicit Racial Bias in the Home Visit Setting
    Type:
    Dataset
    Description/Abstract:
    Data from qualitative study "Employing Strategies to Address Implicit Racial Bias in the Home Visit Setting" Includes: written reflections by FM residents, resident focus group data, commitments-to-change, and 3-month follow up survey data
    Creator/Author:
    Goroncy, Anna
    Submitter:
    Anna Goroncy
    Date Uploaded:
    03/03/2023
    Date Modified:
    03/03/2023
    Date Created:
    2020-01
    License:
    Open Data Commons Attribution License (ODC-By)

  • Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. Holokai et al., 2018

    Dataset thumbnail: Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. Holokai et al., 2018
    Type:
    Dataset
    Description/Abstract:
    ABSTRACT Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death ligand 1 (PD-L1) expression on gastric epithelial cells, yet the mechanism is unknown. We hypothesize that H. pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Shh signaling pathway during infection. To identify the role of Shh signaling as a mediator of H. pylori-induced PD-L1 expression, human gastric organoids generated from either induced pluripotent stem cells (HGOs) or tissue (huFGOs) were microinjected with bacteria and treated with Hedgehog/Gli inhibitor GANT61. Gastric epithelial monolayers generated from the huFGOs were also infected with H. pylori and treated with GANT61 to study the role of Hedgehog signaling as a mediator of induced PD-1 expression. A patient-derived organoid/autologous immune cell co-culture system infected with H. pylori and treated with PD-1 inhibitor (PD-1Inh) was developed to study the protective mechanism of PD-L1 in response to bacterial infection. H. pylori significantly increased PD-L1 expression in organoid cultures 48 hours post-infection when compared to uninfected controls. The mechanism was cytotoxic associated gene A (CagA) dependent. This response was blocked by pretreatment with GANT61. Anti-PD-L1 treatment of H. pylori infected huFGOs, co-cultured with autologous patient cytotoxic T lymphocytes and dendritic cells, induced organoid death. H. pylori-induced PD-L1 expression is mediated by the Shh signaling pathway within the gastric epithelium. Cells infected with H. pylori that express PD-L1 may be protected from the immune response, creating premalignant lesions progressing to gastric cancer.
    Creator/Author:
    Zavros, Yana
    Submitter:
    Yana Zavros
    Date Uploaded:
    12/21/2018
    Date Modified:
    12/21/2018
    Date Created:
    License:
    All rights reserved

  • Air Monitoring for East Liverpool Water Treatment Plant - CARES Data Set 5

    Dataset thumbnail: Air Monitoring for East Liverpool Water Treatment Plant - CARES Data Set 5
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-12 to 2012-01-28 at the East Liverpool Water Treatment Plant, in East Liverpool, Ohio (40.639501 , -80.523561). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - EastLiverpool_WaterTreatmentPlant_Raw.csv . Aggregated monthly averages of the raw data - EastLiverpool_WaterTreatmentPlant_Processed.csv. How the raw data are processed into monthly averages - Marietta_EastLiverpool_WaterTreatmentPlant_WorkingFile.xlsx. How the video is generated- EastLiverpool_WaterTreatmentPlant.ppt. Video - EastLiverpool_WaterTreatmentPlant- generated from EastLiverpool_WaterTreatmentPlant.ppt.
    Creator/Author:
    Yao, Zhiyuan; Hilbert, Tim, and Haynes, Erin
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/27/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-01 to 2018-04
    License:
    CC0 1.0 Universal

  • Air Monitoring for East Liverpool East Elementary School - CARES Data Set 4

    Dataset thumbnail: Air Monitoring for East Liverpool East Elementary School - CARES Data Set 4
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-12 to 2012-01-28 at the East Liverpool East Elementary School, in East Liverpool, Ohio (40.635093 , -80.545558). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese. The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - EastLiverpoolEastElementarySchool_Raw.csv . Aggregated monthly averages of the raw data - EastLiverpoolEastElementarySchool_Processed.csv. How the raw data are processed into monthly averages - Marietta_EastLiverpoolEastElementarySchool_WorkingFile.xlsx. How the video is generated- EastLiverpoolEastElementarySchool.ppt. Video - EastLiverpoolEastElementarySchool- generated from EastLiverpoolEastElementarySchool.ppt.
    Creator/Author:
    Yao, Zhiyuan; Hilbert, Tim, and Haynes, Erin
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/27/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-08-12 to 2012-01-28
    License:
    CC0 1.0 Universal