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  • Promotion of food allergy by the unfolded protein response (preprint)

    Work
    Type:
    Document
    Description/Abstract:
    This is a preprint of a to be submitted paper that demonstrates that: (1) many important food allergens (eggs, milk, peanuts, tree nuts) induce the unfolded protein response (UPR) in intestinal epithelial cells; (2) induction of the UPR, in turn, stimulates the expression of pro-Th2 cytokines (IL-25, IL-33, TSLP) that are required for the induction of food allergy by these cytokines; (3) egg allergy is suppressed in mouse models by the UPR inhibitor, metformin (a drug widely used to treat diabetes mellitus); and (4) metformin appears to have a protective effects in humans who have alpha-gal syndrome, which is a form of food allergy.
    Creator/Author:
    Finkelman, Fred
    Submitter:
    Fred Finkelman
    Date Uploaded:
    06/02/2020
    Date Modified:
    06/02/2020
    Date Created:
    2020-06-02
    License:
    Open Data Commons Attribution License (ODC-By)

  • Developing Best Practices to Address LGBTQ+ Health Disparities - Panelists 3 & 4 - UC Data Day

    6w924d125?file=thumbnail
    Type:
    Document
    Description/Abstract:
    This presentation represents Panelists 3 and 4 as a joint presentation and This talk was the third panelist in the Health Equities and Disparities Session for the 4th Annual UC Data Day Conference hosted by UC Libraries. Joint Talk with Dr. Pickle and Stef Murwsky – Title: Developing Best Practices to Address LGBTQ and Health Disparities Sarah Pickle, MD (she/her/hers), Associate Professor, University of Cincinnati Department of Family and Community Medicine. Dr. Pickle and her colleagues are studying best practices for training future generations of health care professionals in transgender medicine. University of Cincinnati College of Medicine is one of the only US Medical Schools to have a nationally published, dedicated transgender medicine curriculum. Stef Murawsky, MA, WGSS, Ph.D. Candidate, Sociology Pronouns: they/them/theirs University of Cincinnati Department of Sociology I am currently completing a qualitative dissertation that explores transgender patient experiences of navigating and managing a stigmatized gender identity in biomedical contexts. I plan to generate a critical analysis of stigma in healthcare that demonstrates how structural, interpersonal and individual level transgender healthcare experiences are gendered and racialized.
    Creator/Author:
    Murawsky, Stef and Pickel, Sara
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    04/12/2019
    Date Modified:
    04/12/2019
    Date Created:
    2019-04-01
    License:
    Attribution-NonCommercial 4.0 International

  • Understanding Health Disparities and Perceptions of Discrimination in Greater Cincinnati - Panelist 2 - UC Data Day

    41687j49w?file=thumbnail
    Type:
    Document
    Description/Abstract:
    This talk was the second panelist in the Health Equities and Disparities Session for the 4th Annual UC Data Day Conference hosted by UC Libraries. Tammy Mentzel, MPH, Assistant Director for Programs and Projects, University of Cincinnati, Academic Health Center, Cincinnati Cancer Center Talk Title(s): Understanding Health Disparities and Perceptions of Discrimination in Greater Cincinnati Tammy served as the Program Director for the Transformation of Mission-based Health Care through Diversity, Equity, and Inclusion project aimed at bolstering diversity in the health care workforce and eliminating health disparities in urban communities by identifying, testing and adopting evidence-based strategies and tools. Tammy was formerly in the College of Nursing at UC where she was a Research Associate and Program Director providing leadership and support on six funded research projects totaling over $4.6 million.
    Creator/Author:
    Mentzel, Tammy
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    04/12/2019
    Date Modified:
    04/12/2019
    Date Created:
    2019-04-01
    License:
    Attribution-NonCommercial 4.0 International

  • Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. Holokai et al., 2018

    Work
    Type:
    Dataset
    Description/Abstract:
    ABSTRACT Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death ligand 1 (PD-L1) expression on gastric epithelial cells, yet the mechanism is unknown. We hypothesize that H. pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Shh signaling pathway during infection. To identify the role of Shh signaling as a mediator of H. pylori-induced PD-L1 expression, human gastric organoids generated from either induced pluripotent stem cells (HGOs) or tissue (huFGOs) were microinjected with bacteria and treated with Hedgehog/Gli inhibitor GANT61. Gastric epithelial monolayers generated from the huFGOs were also infected with H. pylori and treated with GANT61 to study the role of Hedgehog signaling as a mediator of induced PD-1 expression. A patient-derived organoid/autologous immune cell co-culture system infected with H. pylori and treated with PD-1 inhibitor (PD-1Inh) was developed to study the protective mechanism of PD-L1 in response to bacterial infection. H. pylori significantly increased PD-L1 expression in organoid cultures 48 hours post-infection when compared to uninfected controls. The mechanism was cytotoxic associated gene A (CagA) dependent. This response was blocked by pretreatment with GANT61. Anti-PD-L1 treatment of H. pylori infected huFGOs, co-cultured with autologous patient cytotoxic T lymphocytes and dendritic cells, induced organoid death. H. pylori-induced PD-L1 expression is mediated by the Shh signaling pathway within the gastric epithelium. Cells infected with H. pylori that express PD-L1 may be protected from the immune response, creating premalignant lesions progressing to gastric cancer.
    Creator/Author:
    Zavros, Yana
    Submitter:
    Yana Zavros
    Date Uploaded:
    12/21/2018
    Date Modified:
    12/21/2018
    Date Created:
    License:
    All rights reserved

  • Air Monitoring for East Liverpool Water Treatment Plant - CARES Data Set 5

    Ft848r62d?file=thumbnail
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-12 to 2012-01-28 at the East Liverpool Water Treatment Plant, in East Liverpool, Ohio (40.639501 , -80.523561). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - EastLiverpool_WaterTreatmentPlant_Raw.csv . Aggregated monthly averages of the raw data - EastLiverpool_WaterTreatmentPlant_Processed.csv. How the raw data are processed into monthly averages - Marietta_EastLiverpool_WaterTreatmentPlant_WorkingFile.xlsx. How the video is generated- EastLiverpool_WaterTreatmentPlant.ppt. Video - EastLiverpool_WaterTreatmentPlant- generated from EastLiverpool_WaterTreatmentPlant.ppt.
    Creator/Author:
    Yao, Zhiyuan; Hilbert, Tim, and Haynes, Erin
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/27/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-01 to 2018-04
    License:
    CC0 1.0 Universal

  • Air Monitoring for East Liverpool East Elementary School - CARES Data Set 4

    K930bz14c?file=thumbnail
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-12 to 2012-01-28 at the East Liverpool East Elementary School, in East Liverpool, Ohio (40.635093 , -80.545558). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese. The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - EastLiverpoolEastElementarySchool_Raw.csv . Aggregated monthly averages of the raw data - EastLiverpoolEastElementarySchool_Processed.csv. How the raw data are processed into monthly averages - Marietta_EastLiverpoolEastElementarySchool_WorkingFile.xlsx. How the video is generated- EastLiverpoolEastElementarySchool.ppt. Video - EastLiverpoolEastElementarySchool- generated from EastLiverpoolEastElementarySchool.ppt.
    Creator/Author:
    Yao, Zhiyuan; Hilbert, Tim, and Haynes, Erin
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/27/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-08-12 to 2012-01-28
    License:
    CC0 1.0 Universal

  • Air Monitoring for Marietta Ohio Valley Educational Service Center - CARES Data Set 3

    7p88ch45w?file=thumbnail
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-17 to 2012-02-25 at the Ohio Valley Educational Service Center in Marietta, Ohio (39.443477 , -81.452199). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - Marietta_OhioValleyEducationalServiceCenter_Raw.csv . Aggregated monthly averages of the raw data - Marietta_OhioValleyEducationalServiceCenter_Processed.csv. How the raw data are processed into monthly averages - Marietta_OhioValleyEducationalServiceCenter_WorkingFile.xlsx. How the video is generated- Marietta_OhioValleyEducationalServiceCenter.ppt. Video - Marietta_OhioValleyEducationalServiceCenter - generated from Marietta_OhioValleyEducationalServiceCenter.ppt.
    Creator/Author:
    Yao, Zhiyuan; Hilbert, Tim, and Haynes, Erin
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/27/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-08-17 to 2012-02-25
    License:
    CC0 1.0 Universal

  • Air Monitoring for Marietta Warren Elementary School - CARES Data Set 2

    6395w809n?file=thumbnail
    Type:
    Dataset
    Description/Abstract:
    This data set and accompanying files represents air monitoring data collected by the Environmental Protection Agency from 2009-08-17 to 2012-02-25 at the Warren Elementary School in Marietta, Ohio (39.393536, -81.554015). The variables of interest were the amount of manganese and lead in the air measured as PM10 particle size. The visualizations were created from monthly averages for the concentration of airborne manganese. The data was collected using the TO-15 collection systems for air monitoring device. (reference -  https://www3.epa.gov/air/sat/pdfs/VocTechdocwithappendix1209.pdf) The files included are: The raw data - Marietta_WarrenElementraySchool_Raw.csv . Aggregated monthly averages of the raw data - Marietta_WarrenElementraySchool_Processed.csv. How the raw data are processed into monthly averages - Marietta_WarrenElementraySchool_WorkingFile.xlsx. How the video is generated- Marietta_WarrenElementraySchool.ppt. Video - Marietta_WarrenElementraySchool.mp4 - generated from Marietta_WarrenElementraySchool.ppt.
    Creator/Author:
    Erin Hayes; Zhiyuan Yao, and Tim Hilbert
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    10/26/2018
    Date Modified:
    07/11/2019
    Date Created:
    2009-08-17 to 2012-02-25
    License:
    CC0 1.0 Universal

  • Identifying a Novel Role for the Retrosplenial Cortex in Alzheimer's Disease

    Cv43nx37f?file=thumbnail
    Type:
    Image
    Description/Abstract:
    The Retrosplenial Cortex (RSC) has a persistent role in the establishment of spatial and contextual memory, with also the connections between visuo-spatial association cortices. The RSC’s ability to form afferent and efferent connections with the Parahippocampal areas of the brain allow it to be another prime location in the brains of both rodents and humans where multiple cues are linked together in memory formation, storage and retrieval of Long Term Memories. Due to the high nature of memory formation and retrieval, the RSC has become a section of the brain that in recent years has been more heavily focused on for the research of Alzheimer’s and Dementia. The RSC has not been examined fully in previous studies with examination of the expression of the apolipoprotein E (APOE) gene along with other genetic and regulatory factors. There are 3 major alleles of the APOE gene (APOE2, APOE3, and APOE4), with APOE4 having the greatest risk for AD. In this research, I identify the relative connection between DEK the proto-oncogene and APOE3 and APOE4 in a rodent model, looking specifically at the RSC and how it affects spatial memory with an induced model of chronic stress.
    Creator/Author:
    Solomon, Matia B.; Balmer, Nikolaus J.; Selmanovic, Din; Nguyen, Elizabeth T., and Ghisays, Valentina
    Submitter:
    Din Selmanovic
    Date Uploaded:
    06/27/2018
    Date Modified:
    06/27/2018
    Date Created:
    2018-04-13
    License:
    Public Domain Mark 1.0

  • A New Sarcoidosis Diagnostic Score

    Work
    Type:
    Student Work
    Description/Abstract:
    Summary: The diagnosis of sarcoidosis is made by the combination of clinical features and biopsy results. The clinical features of sarcoidosis can be quite variable. We developed a Sarcoidosis Diagnostic Score (SDS) to summarize the clinical features of possible sarcoidosis patients. Biopsy confirmed sarcoidosis patients seen during a seven-month time period at the University of Cincinnati Sarcoidosis clinic were prospectively identified. Non-sarcoidosis patients seen at the same clinic were used as controls. Using a modified WASOG organ assessment instrument, we scored all patients for presence of biopsy, one or more highly probable symptom, and one or more at least probable symptom for each area. Two sarcoidosis scores were generated: SDS biopsy (with biopsy) and SDS clinical (without biopsy).The 980 evaluable patients were divided into two cohorts: an initial 600 patients (450 biopsy confirmed sarcoidosis, 150 controls) to establish cut-off values for SDS biopsy and SDS clinical and a validation cohort of 380 patients (103 biopsy confirmed sarcoidosis patients and 277 controls). The best cutoff value for SDS biopsy was > 6 (sensitivity =99.3%; specificity=100%). For the total the 980 patients, an SDS clinical > 3 had a sensitivity of 94.2%, specificity of 88.8%, and a likelihood ratio of 7.9. An SDS clinical score > 4 had a lower sensitivity of (76.9%) but higher specificity (98.6%). For sarcoidosis, the presence of specific clinical features, especially multi-organ involvement, can enhance the diagnostic certainty. The SDS scoring system quantitated the clinical features consistent with sarcoidosis. Awards/Publications: Published in CHEST Journal 2018 Oral presentation at the 2018 American Thoracic Society Conference
    Creator/Author:
    Lower, Elyse E., M.D.; Baughman, Robert P., M.D., and Bickett, Alexandra
    Submitter:
    Alexandra Bickett
    Date Uploaded:
    05/24/2018
    Date Modified:
    05/24/2018
    Date Created:
    2018-04-15
    License:
    Attribution-ShareAlike 4.0 International