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  • De-identifying Data

    Media thumbnail: De-identifying Data
    Type:
    Media
    Description/Abstract:
    This webinar aired on January 12, 2016 for members of the DataCure listserv. The webinar covered issues around sensitive data and how to establish a educational program to help researchers protect sensitive data while sharing results of their research. The presenters were Brett Harnett, Director of the UC Center for Health Informatics ( http://www.med.uc.edu/chi) and Jonathan Petters Ph.D. Data Management Consultant at Johns Hopkins University ( http://dmp.data.jhu.edu/). Presentation 1 - Brett Harnett- the process of de-identifying data especially data resulting from medical records, issues around de-identifying especially unstructured data, working with an IRB and future issues concerning data containing PHI. Presentation 2 - Jonathan Petters - training for de-identifying human subjects data for sharing and developing a viable library service.
    Creator/Author:
    Koshoffer, Amy; Harnett, Brett, and Petters, Jonathan
    Submitter:
    Amy Koshoffer
    Date Uploaded:
    03/09/2016
    Date Modified:
    11/18/2016
    Date Created:
    2016-03-09
    License:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • Flip It

    Media thumbnail: Flip It
    Type:
    Media
    Description/Abstract:
    Two channels or two versions of a video made with an early non-linear editing system "The Video Cube." Purchased by Matt Dibble, to which I made a contribution and got some time on the system. The tape attempts to form a series of wipes as if constantly changing channels. All footage is appropriated from cable tv.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    04/02/2017
    Date Modified:
    05/08/2019
    Date Created:
    1999-06-01
    License:
    All rights reserved

  • Betty Woodman: Thinking Out Loud

    Media thumbnail: Betty Woodman: Thinking Out Loud
    Type:
    Media
    Description/Abstract:
    Filmed on VHS, mastered on Betacam SP at Public Production Group, Washington DC. Ceramic artist Betty Woodman demonstrates her technique of ceramic art, discusses her background and talks with critic, curator and painter John Perreault about her work.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/20/2017
    Date Modified:
    05/08/2019
    Date Created:
    1991-05-31
    License:
    All rights reserved

  • Partida

    Media thumbnail: Partida
    Type:
    Media
    Description/Abstract:
    Produced on ¾" tape at Center for Contemporary Art, Santa Fe; features music by the Memluks, a band from Norman, OK, and appearances by my friend Willy.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/20/2017
    Date Modified:
    05/07/2019
    Date Created:
    1985-01-31
    License:
    All rights reserved

  • Personal Jesus

    Media thumbnail: Personal Jesus
    Type:
    Media
    Description/Abstract:
    The image was filmed off a decorative plate with a live camera which was being processed dimming, and then coming to brightness then back again. It looks like the hue was off too, giving Jesus a green tint. Produced during a residency at the Experimental TV Center.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/19/2017
    Date Modified:
    05/07/2019
    Date Created:
    1993-06-01
    License:
    All rights reserved

  • Mixed Fish with Clouds

    Media thumbnail: Mixed Fish with Clouds
    Type:
    Media
    Description/Abstract:
    This is an early installation video shown at a gallery at Millersville University and projected onto the ceiling. All footage is original.
    Creator/Author:
    Woodman, Charles
    Submitter:
    Charles Woodman
    Date Uploaded:
    03/19/2017
    Date Modified:
    05/07/2019
    Date Created:
    1994-06-01
    License:
    All rights reserved

  • Development of a Database Program and Networking System For Seven Hills Neighborhood Houses

    Student Work thumbnail: Development of a Database Program and Networking System For Seven Hills Neighborhood Houses
    Type:
    Student Work
    Description/Abstract:
    Submitted to the Faculty of the Information Engineering Technology Program in Partial Fulfillment of the Requirements for the Degree of Bachelor of Science in Information Engineering Technology
    Creator/Author:
    Morrison, Matthew Edward
    Submitter:
    CECH Library Service
    Date Uploaded:
    03/09/2017
    Date Modified:
    05/23/2019
    Date Created:
    2003-03-14
    License:
    Attribution-NonCommercial-NoDerivs 4.0 International

  • The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases

    Article thumbnail: The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases
    Type:
    Article
    Description/Abstract:
    Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2. Results: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome. Conclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome. Significance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease).
    Creator/Author:
    Grabowski, Gregory A.; Haffey, Wendy D.; Greis, Kenneth D., and Llou, Benjamin
    Submitter:
    Kenneth Greis
    Date Uploaded:
    03/03/2017
    Date Modified:
    04/07/2017
    Date Created:
    2014-09
    License:
    All rights reserved

  • Advanced hair damage model from ultra-violet radiation in the presence of copper

    Article thumbnail: Advanced hair damage model from ultra-violet radiation in the presence of copper
    Type:
    Article
    Description/Abstract:
    OBJECTIVE: Damage to hair from UV exposure has been well reported in the literature and is known to be a highly complex process involving initiation via absorption of UV light followed by formation and propagation of reactive oxygen species (ROS). The objective of this work was to understand these mechanisms, explain the role of copper in accelerating the formation of ROS and identify strategies to reduce the hair damage caused by these reactive species. METHODS: The location of copper in hair was measured by Transmission electron microscopy–(TEM) X-ray energy dispersive spectroscopy (XEDS) and levels measured by ICP-OES. Protein changes were measured as total protein loss via the Lowry assay, and MALDI ToF was used to identify the biomarker protein fragments. TBARS assay was used to measure lipid peroxide formation. Sensory methods and dry combing friction were used to measure hair damage due to copper and UV exposure and to demonstrate the efficacy of N,N’ ethylenediamine disuccinic acid (EDDS) and histidine chelants to reduce this damage. RESULTS: In this work, a biomarker protein fragment formed during UV exposure is identified using mass spectrometry. This fragment originates from the calcium-binding protein S100A3. Also shown is the accelerated formation of this peptide fragment in hair containing low levels of copper absorbed from hair during washing with tap water containing copper ions. Transmission electron microscopy (TEM) X-ray energy dispersive spectroscopy (XEDS) studies indicate copper is located in the sulphur-poor endo-cuticle region, a region where the S100A3 protein is concentrated. A mechanism for formation of this peptide fragment is proposed in addition to the possible role of lipids in UV oxidation. A shampoo and conditioner containing chelants (EDDS in shampoo and histidine in conditioner) is shown to reduce copper uptake from tap water and reduce protein loss and formation of S100A3 protein fragment. In addition, the long-term consequences of UV oxidation and additional damage induced by copper are illustrated in a fourmonth wear study where hair was treated with a consumer relevant protocol of hair colouring treatments, UV exposure and regular shampoo and conditioning. CONCLUSIONS: The role of copper in accelerating UV damage to hair has been demonstrated as well as the ability of chelants such as EDDS and histidine in shampoo and conditioner products to reduce this damage.
    Creator/Author:
    McComb, D. W.; Marsh, J. M.; Sun, Y.; Chaudhary, T.; Flagler, M. J.; Coderch, L.; Mamak, M.; Greis, Kenneth D.; Rubio, L.; Williams, R. E. A., and Davis, M. G.
    Submitter:
    Kenneth Greis
    Date Uploaded:
    03/03/2017
    Date Modified:
    04/07/2017
    Date Created:
    2015-04
    License:
    All rights reserved

  • Transformations in pharmaceutical research and development, driven by innovations in multidimensional mass spectrometry-based technologies

    Article thumbnail: Transformations in pharmaceutical research and development, driven by innovations in multidimensional mass spectrometry-based technologies
    Type:
    Article
    Description/Abstract:
    In the pharmaceutical industry, there is a tremendous need for qualitative and quantitative analysis of target analytes such as peptides, proteins, drugs, metabolites, biomarkers, impurities, and degradation products in various mixtures including synthetic reactions, in vitro cultures, biological fluids, drug substances, finished products, and many others. To provide adequate specificity for analysis in these complex mixtures, multidimensional analytical techniques are required. Mass spectrometry plays a central role in many of these multidimensional approaches to mixture analysis because it provides an unparalleled combination of sensitivity and specificity that is useful for both molecular identification and quantitative applications. Recent innovations in mass spectrometry and industrial implementation of these advances have transformed many aspects of pharmaceutical research and development. Data that were previously unattainable, or were not collected due to exorbitant cost or time constraints, can now be obtained using mass spectrometry-based technologies. The impact of these innovations has been most dramatically felt in early stages of discovery, as more data are available to make critical decisions, such as selecting compounds for advancement to costly preclinical and clinical trials. New MS technologies have also accelerated the progression of drug candidates through development and toward regulatory approval. Here, five major categories of pharmaceutical applications of mass spectrometry are reviewed. They are new chemical entity characterization, biomacromolecule characterization, bioanalytical quantitation, metabolite identification, and impurity and degradation product identification. A brief historical perspective and evolution of technologies for each application area are presented. Those discussions are followed with a description of the current strategies for implementation of the tremendous capabilities of the state-of-the-art approaches, along with representative applications. In addition, emerging technologies for each application area are presented to indicate the future directions of instrumentation for mixture analysis in the pharmaceutical industry. (Int J Mass Spectrom 212 (2001) 135–196) © 2001 Elsevier Science B.V.
    Creator/Author:
    Harbol, Kevin L.; Greis, Kenneth D.; Hoke, Steven H.; Morand, Kenneth L.; Baker, Timothy R., and Dobson, Roy L. M.
    Submitter:
    Kenneth Greis
    Date Uploaded:
    03/03/2017
    Date Modified:
    04/07/2017
    Date Created:
    2001-11
    License:
    All rights reserved