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The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases Open Access Deposited

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Last modified: 04/07/2017

Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2.

Results: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome.

Conclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome.

Significance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease).

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  • Journal of Biological Chemistry
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  • This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review

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Identifier: 10.1074/jbc.M114.593616
Link: http://dx.doi.org/10.1074/jbc.M114.593616

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