Article
The Limp-2/scarb2 Binding Motif On Acid Beta-glucosidase Basic And Applied Implications For Gaucher Disease And Associated Neurodegenerative Diseases Open Access Deposited
Background: Acid -glucosidase is trafficked to the lysosome by LIMP-2.
Results: A unique 11-amino acid sequence on acid -glucosidase was critical for its LIMP-2-dependent targeting to the lysosome.
Conclusion: This sequence is essential for oligosaccharide-independent targeting of synthesized acid -glucosidase to the lysosome.
Significance: Modification of this sequence has basic/therapeutic implications for Gaucher disease and its comorbidities (e.g. Parkinson disease).
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This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review
Digital Object Identifier (DOI)
Identifier: 10.1074/jbc.M114.593616
Link: https://doi.org/10.1074/jbc.M114.593616
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