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Type:
Document
Description/Abstract:
This is a preprint of a to be submitted paper that demonstrates that: (1) many important food allergens (eggs, milk, peanuts, tree nuts) induce the unfolded protein response (UPR) in intestinal epithelial cells; (2) induction of the UPR, in turn, stimulates the expression of pro-Th2 cytokines (IL-25, IL-33, TSLP) that are required for the induction of food allergy by these cytokines; (3) egg allergy is suppressed in mouse models by the UPR inhibitor, metformin (a drug widely used to treat diabetes mellitus); and (4) metformin appears to have a protective effects in humans who have alpha-gal syndrome, which is a form of food allergy.
Creator/Author:
Finkelman, Fred Submitter:
Fred Finkelman Date Uploaded:
06/02/2020
Date Modified:
06/02/2020
Date Created:
2020-06-02 License:
Open Data Commons Attribution License (ODC-By)
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
Type:
Dataset
Description/Abstract:
Metadata sheet with more in-depth information regarding files and the location of physical files.
Creator/Author:
Center, Simpson Submitter:
Simpson Center Date Uploaded:
06/02/2020
License:
All rights reserved
