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Apolipoprotein A-II-mediated Conformational Changes of Apolipoprotein A-I in Discoidal High Density Lipoproteins Open Access Deposited

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Date Modified: 04/07/2017

Background: Role of apolipoprotein (apo) A-II on metabolism of high density lipoproteins (HDLs) is unknown.

Results: Conformational changes of apoA-I, the major apolipoprotein of HDL, caused by apoA-II in discoidal HDL are confined to two regions of apoA-I.

Conclusion: Interactions between the two major apolipoproteins in discoidal HDL are site specific.

Significance: Functional implications of HDL complexes will significantly benefit from such structural information.

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  • Journal of Biological Chemistry
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  • This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review

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Identifier: DOI 10.1074/jbc.M111.291070
Link: http://dx.doi.org/DOI%2010.1074/jbc.M111.291070

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Permanent link to this page: https://scholar.uc.edu/show/bc3870851