Acute Myelomonocytic Leukemia and its Clinical Presentation

Woodward, Kati

Student Work

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Date Uploaded: 05/09/2017
Date Modified: 05/09/2017

A 67-year-old female presented with an abnormal complete blood count (CBC) when arriving for an angiogram. An abnormal white blood cell (WBC) differential showed 17% blasts which led her physician to have a bone marrow biopsy performed. The bone marrow aspirate smear showed an increased number of blasts and the bone marrow core biopsy revealed 90% cellularity where normal precursors were replaced by blasts. Flow cytometry and chromosome analysis results were consistent with Acute Myelomonocytic Leukemia (AMML). The patient was placed on FLAG chemotherapy until a goal of 0.9-1.0x10^9/L absolute neutrophil count is achieved, at which time a catheter will be placed to address her cardiac comorbidities. Cardiac disease and AML comorbidities are a commonly encountered issue in oncology patients. Due to this patient’s history of cardiac disease, treating her AML is more complicated in order to ensure that chemotherapy does not worsen her cardiac complications.

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