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Promotion of food allergy by the unfolded protein response (preprint) Open Access Deposited

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Date Uploaded: 06/02/2020
Date Modified: 06/02/2020

This is a preprint of a to be submitted paper that demonstrates that: (1) many important food allergens (eggs, milk, peanuts, tree nuts) induce the unfolded protein response (UPR) in intestinal epithelial cells; (2) induction of the UPR, in turn, stimulates the expression of pro-Th2 cytokines (IL-25, IL-33, TSLP) that are required for the induction of food allergy by these cytokines; (3) egg allergy is suppressed in mouse models by the UPR inhibitor, metformin (a drug widely used to treat diabetes mellitus); and (4) metformin appears to have a protective effects in humans who have alpha-gal syndrome, which is a form of food allergy.

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  • Promotion of food allergy by the UPR
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  • This is a preprint of a scientific paper that will be submitted for publication

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Identifier: doi:10.7945/s0m9-8266
Link: https://doi.org/10.7945/s0m9-8266

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