Article

Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates
Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased
insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.
Stat3-mediated modification plays a role in early tumorigenesis.

Creator

• Spinner, R. J.
• Ratner, N.
• Largaespada, D. A.
• Keng, V.
• Patmore, D. M.
• Wu, J.
• Cancelas, Jose A.

License

• All rights reserved

Submitter

Jose Cancelas

College

• Medicine

Department

• Hoxworth Blood Center

Date Created

• 2016-02

Publisher

• Cell Reports

Journal Title

• Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis.

Note

• This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review

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