Article

 

Insertional Mutagenesis Identifies a STAT3/Arid1b/ b-catenin Pathway Driving Neurofibroma Initiation Open Access Deposited

Downloadable Content

Download PDF
Download Adobe Acrobat Reader
Date Uploaded: 02/08/2017
Date Modified: 04/10/2017

Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates
Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased
insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.
Stat3-mediated modification plays a role in early tumorigenesis.

Creator
License
Submitter
College
Department
Date Created
Publisher
Journal Title
  • Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis.
Note
  • This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review

Relationships

Items

Permanent link to this page: https://scholar.uc.edu/show/bc386t17p