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Insertional Mutagenesis Identifies a STAT3/Arid1b/ b-catenin Pathway Driving Neurofibroma Initiation 开放存取 Deposited

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Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates
Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased
insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance.
Stat3-mediated modification plays a role in early tumorigenesis.

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  • Wu et al. map an Nf1-Stat3-Arid1b/ b-catenin pathway that initiates Neurofibromatosis type 1 (Nf1) neurofibromas, using unbiased insertional mutagenesis screening. Stat3 transcriptionally represses Gsk3b and Arid1b, thereby activating b-catenin in Schwann cell precursors and resulting in neurofibroma initiation and maintenance. Stat3-mediated modification plays a role in early tumorigenesis.
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  • This work was part of a pilot "mediated-deposit model" where library staff found potential works, later submitted for faculty review

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